Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors
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Targeting the Bcl-2 family for cancer therapyScreening and characterisation of antimicrobial properties of semisynthetic betulin derivativesBetulin is a potent anti-tumor agent that is enhanced by cholesterol.Natural triterpenic diols promote apoptosis in astrocytoma cells through ROS-mediated mitochondrial depolarization and JNK activationEffect of betulinic acid on the regulation of Hiwi and cyclin B1 in human gastric adenocarcinoma AGS cells.Betulinic acid suppresses constitutive and TNFalpha-induced NF-kappaB activation and induces apoptosis in human prostate carcinoma PC-3 cells.Betulinic acid suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase SHP-1 in human multiple myeloma cells.Suppression of STAT3 and HIF-1 alpha mediates anti-angiogenic activity of betulinic acid in hypoxic PC-3 prostate cancer cells.Betulinic acid induces apoptosis and inhibits hedgehog signalling in rhabdomyosarcoma.NF-kappaB activation enhances cell death by antimitotic drugs in human prostate cancer cells.Proteomic investigation into betulinic acid-induced apoptosis of human cervical cancer HeLa cellsBetulinic acid inhibits autophagic flux and induces apoptosis in human multiple myeloma cells in vitroAcetaminophen induces human neuroblastoma cell death through NFKB activation.Inhibition of phosphotidylinositol-3 kinase pathway by a novel naphthol derivative of betulinic acid induces cell cycle arrest and apoptosis in cancer cells of different origin.Sequential treatment with betulinic acid followed by 5-fluorouracil shows synergistic cytotoxic activity in ovarian cancer cells.Combining betulinic acid and mithramycin a effectively suppresses pancreatic cancer by inhibiting proliferation, invasion, and angiogenesisNew ionic derivatives of betulinic acid as highly potent anti-cancer agents.Null mutation of DNA strand break-binding molecule poly(ADP-ribose) polymerase causes medulloblastomas in p53(-/-) mice.Identification of a novel pro-apopotic function of NF-kappaB in the DNA damage response.The effect of 3β, 6β, 16β-trihydroxylup-20(29)-ene lupane compound isolated from Combretum leprosum Mart. on peripheral blood mononuclear cells.A potent betulinic acid analogue ascertains an antagonistic mechanism between autophagy and proteasomal degradation pathway in HT-29 cellsAvicins: triterpenoid saponins from Acacia victoriae (Bentham) induce apoptosis by mitochondrial perturbationNOXA as critical mediator for drug combinations in polychemotherapy.Betulinic acid decreases ER-negative breast cancer cell growth in vitro and in vivo: role of Sp transcription factors and microRNA-27a:ZBTB10Betulinic acid enhances TGF-β signaling by altering TGF-β receptors partitioning between lipid-raft/caveolae and non-caveolae membrane microdomains in mink lung epithelial cells.Mitochondrial permeability transition pore as a selective target for anti-cancer therapyBetulinic acid augments the inhibitory effects of vincristine on growth and lung metastasis of B16F10 melanoma cells in mice.Identification of non-canonical NF-κB signaling as a critical mediator of Smac mimetic-stimulated migration and invasion of glioblastoma cells.Cancer preventive agents 9. Betulinic acid derivatives as potent cancer chemopreventive agents.A Module Analysis Approach to Investigate Molecular Mechanism of TCM Formula: A Trial on Shu-feng-jie-du Formula.The natural product betulinic acid rapidly promotes amyloid-β fibril formation at the expense of soluble oligomers.Small mitochondria-targeting molecules as anti-cancer agents.Increased betulinic acid induced cytotoxicity and radiosensitivity in glioma cells under hypoxic conditions.Betulinic Acid-Mediated Apoptosis in Human Prostate Cancer Cells Involves p53 and Nuclear Factor-Kappa B (NF-κB) Pathways.Identification of IRF1 as critical dual regulator of Smac mimetic-induced apoptosis and inflammatory cytokine response.Betulinic acid-induced mitochondria-dependent cell death is counterbalanced by an autophagic salvage response.Identification of DR5 as a critical, NF-κB-regulated mediator of Smac-induced apoptosis.Betulinic acid induces Bax/Bak-independent cytochrome c release in human nasopharyngeal carcinoma cells.Impairment of lysosomal integrity by B10, a glycosylated derivative of betulinic acid, leads to lysosomal cell death and converts autophagy into a detrimental process.Requirement of nuclear factor κB for Smac mimetic-mediated sensitization of pancreatic carcinoma cells for gemcitabine-induced apoptosis.
P2860
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P2860
Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors
description
1997 nî lūn-bûn
@nan
1997 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Betulinic acid triggers CD95 ( ...... ases in neuroectodermal tumors
@ast
Betulinic acid triggers CD95 ( ...... ases in neuroectodermal tumors
@en
Betulinic acid triggers CD95 ( ...... ases in neuroectodermal tumors
@nl
type
label
Betulinic acid triggers CD95 ( ...... ases in neuroectodermal tumors
@ast
Betulinic acid triggers CD95 ( ...... ases in neuroectodermal tumors
@en
Betulinic acid triggers CD95 ( ...... ases in neuroectodermal tumors
@nl
prefLabel
Betulinic acid triggers CD95 ( ...... ases in neuroectodermal tumors
@ast
Betulinic acid triggers CD95 ( ...... ases in neuroectodermal tumors
@en
Betulinic acid triggers CD95 ( ...... ases in neuroectodermal tumors
@nl
P2093
P1433
P1476
Betulinic acid triggers CD95 ( ...... ases in neuroectodermal tumors
@en
P2093
Benedict M
Krammer PH
Scaffidi C
P304
P407
P577
1997-11-01T00:00:00Z