Molecular determinants of voltage-dependent human ether-a-go-go related gene (HERG) K+ channel block.
about
Blockade of HERG potassium currents by fluvoxamine: incomplete attenuation by S6 mutations at F656 or Y652In silico analysis of conformational changes induced by mutation of aromatic binding residues: consequences for drug binding in the hERG K+ channelAn antiarrhythmic agent as a promising lead compound for targeting the hEAG1 ion channel in cancer therapy: insights from molecular dynamics simulations.Inherited and acquired vulnerability to ventricular arrhythmias: cardiac Na+ and K+ channels.Identification and characterization of a compound that protects cardiac tissue from human Ether-à-go-go-related gene (hERG)-related drug-induced arrhythmiasThe 5-HT2 antagonist ketanserin is an open channel blocker of human cardiac ether-à-go-go-related gene (hERG) potassium channels.Drug binding to HERG channels: evidence for a 'non-aromatic' binding site for fluvoxamineAntimalarial drugs: QT prolongation and cardiac arrhythmias.The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel.Molecular mechanisms for drug interactions with hERG that cause long QT syndrome.Methadone-associated long QT syndrome: improving pharmacotherapy for dependence on illegal opioids and lessons learned for pharmacology.Interaction of local anesthetics with the K (+) channel pore domain: KcsA as a model for drug-dependent tetramer stabilityBlock of HERG k channel by classic histamine h(1) receptor antagonist chlorpheniramine.Voltage-gated potassium channels as therapeutic targets.Effects of the histamine H(1) receptor antagonist hydroxyzine on hERG K(+) channels and cardiac action potential duration.Revealing the structural basis of action of hERG potassium channel activators and blockers.Piperaquine Population Pharmacokinetics and Cardiac Safety in Cambodia.Assessing hERG pore models as templates for drug docking using published experimental constraints: the inactivated state in the context of drug block.Cardiotoxicity screening: a review of rapid-throughput in vitro approaches.hERG quality control and the long QT syndrome.Development of Safe Drugs: The hERG Challenge.Chloroquine blocks a mutant Kir2.1 channel responsible for short QT syndrome and normalizes repolarization properties in silico.Molecular determinants of hERG channel block by terfenadine and cisapride.Coexistence of hERG current block and disruption of protein trafficking in ketoconazole-induced long QT syndrome.Mechanism of hERG K+ channel blockade by the fluoroquinolone antibiotic moxifloxacin.Blockade of HERG cardiac K+ current by antifungal drug miconazoleRole of the activation gate in determining the extracellular potassium dependency of block of HERG by trapped drugs.Trapping and dissociation of propafenone derivatives in HERG channels.Exploring blocker binding to a homology model of the open hERG K+ channel using docking and molecular dynamics methods.Molecular basis for Kv1.5 channel block: conservation of drug binding sites among voltage-gated K+ channels.Inactivation and recovery in Kv1.4 K+ channels: lipophilic interactions at the intracellular mouth of the pore.Physicochemical features of the HERG channel drug binding site.Characterization of hydrated Na+(phenol) and K+(phenol) complexes using infrared spectroscopy.Modulation of HERG potassium channel function by drug action.Verapamil blocks HERG channel by the helix residue Y652 and F656 in the S6 transmembrane domain.hERG Blockade by Iboga Alkaloids.Clenbuterol Attenuates hERG Channel by Promoting the Mature Channel Degradation.New synthetic approaches towards analogues of bedaquiline.Structural implications of hERG K+ channel block by a high-affinity minimally structured blocker.Investigating the state dependence of drug binding in hERG channels using a trapped-open channel phenotype.
P2860
Q24672572-CFAB1C4E-D73C-44D5-B142-D30C526F43FEQ27311255-7FC9C8DD-24C9-464C-B331-E36436B81776Q30388863-060F3AED-61D9-4261-8270-95CBB780BCE4Q33152183-C5BF43A9-F29B-4BC0-91EA-10535E904856Q34432897-244D367C-A788-4E38-856B-E7667FDB27F7Q34656562-8F8A0D07-94C3-4C5D-B54C-19FED17F468EQ35168590-B0F6D8A2-C3D4-4E84-8E8F-52113B3E32A1Q36150536-A4D69583-CF6A-48DF-8993-CC3401301D5FQ36446243-6DC1FD57-D40C-4733-9548-01676B1F52BCQ36545039-C50FBB52-26BD-41A8-B7DF-15E490366DF8Q36811537-9CEB0DE3-6E34-4497-9E3E-A18DAE1D64D4Q37009060-BFADDA4F-3F54-4A01-828D-598FCF1CEAA3Q37398466-85F79864-EC1C-4A4C-94FB-9A8FCD5497A2Q37464784-0D8CE4B0-E7ED-463A-93E5-80F8BDA7E069Q37729796-2AB17424-E71E-4872-92EB-1DBBEE5F698AQ37774138-8D52C7C2-EDE2-4A3F-8DB2-B73FF606EA0EQ38380902-8D48F6B0-F72F-4AED-9039-22AF9B9194C3Q38632776-3F07EC8B-EE63-4320-8165-3D55FD3960F3Q38671689-9058B71C-8B9A-47B9-91CD-086BBF4D4A49Q38683556-1BF1F262-889D-4A82-8A7E-E3DDA50D2A2EQ39280559-668B4258-9B31-4B69-B6D5-2922DE02F0FEQ39807663-7B3D4B46-F672-4725-88C7-94A132EFD27DQ39810055-0AF6BAF5-8E40-4E4B-BBDE-47F1054E4452Q40061024-AEAE965D-909D-4250-BEC9-79B32EF092BAQ40317287-B6192C3E-18E6-4702-A06B-CEF8C153A762Q40444927-2C2569B7-9AB0-498F-93A9-FBC9B1B663A7Q41566606-9259BCD5-F29F-4495-A778-7EC19B7F5342Q42197396-F7DA6BAE-ABEF-497A-A1E6-E28B19BCC203Q42656435-7E05BAA1-C0CE-4F48-9D1F-66306251465EQ44631900-B75B8BB3-2EF9-446A-8CA0-A495F36FFE28Q44649182-ABBD8E17-9182-4D03-8436-7962CFEF994EQ44709094-FED22D43-B774-46A0-A224-CF7C01B30349Q44988786-107C07FF-A318-433D-9494-461711ECC400Q47398479-6171F710-48B8-449A-9DBB-A5ABD2BD3C06Q48788779-E9FB010A-F2AB-4B7C-B820-CD9D6B3F38EDQ50599350-E31FE5FE-91ED-44B1-BAA2-A06EE721E074Q50628884-DBCB85D4-0F3B-426F-ADD0-F19B07A7D5D9Q53767185-51DD9506-C0D3-43B2-AEFC-0E7C3DBD8E94Q53837170-31F12F36-6B37-4E78-B902-4D8455CDDB52Q54942021-F0C6EBFC-7468-4C2C-A713-51F49A89D6C8
P2860
Molecular determinants of voltage-dependent human ether-a-go-go related gene (HERG) K+ channel block.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Molecular determinants of volt ...... gene (HERG) K+ channel block.
@en
Molecular determinants of voltage-dependent human ether-a-go-go related gene
@nl
type
label
Molecular determinants of volt ...... gene (HERG) K+ channel block.
@en
Molecular determinants of voltage-dependent human ether-a-go-go related gene
@nl
prefLabel
Molecular determinants of volt ...... gene (HERG) K+ channel block.
@en
Molecular determinants of voltage-dependent human ether-a-go-go related gene
@nl
P2093
P2860
P356
P1476
Molecular determinants of volt ...... gene (HERG) K+ channel block.
@en
P2093
Chris Culberson
Jose A Sánchez-Chapula
Michael C Sanguinetti
Ricardo A Navarro-Polanco
P2860
P304
23587-23595
P356
10.1074/JBC.M200448200
P407
P577
2002-04-17T00:00:00Z