Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice. - Wikidata - awgldk - TriplyDB

Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice.

Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice.

http://www.wikidata.org/entity/Q39426103

about

Pax6 controls the expression of critical genes involved in pancreatic {alpha} cell differentiation and function Pax6 is crucial for β-cell function, insulin biosynthesis, and glucose-induced insulin secretion Reexpression of oncoprotein MafB in proliferative β-cells and Men1 insulinomas in mouse Analysis of beta-cell gene expression reveals inflammatory signaling and evidence of dedifferentiation following human islet isolation and culture Identification of known and novel pancreas genes expressed downstream of Nkx2.2 during development Regenerating pancreatic beta-cells: plasticity of adult pancreatic cells and the feasibility of in-vivo neogenesis.TAT-mediated transduction of MafA protein in utero results in enhanced pancreatic insulin expression and changes in islet morphology Arx and Nkx2.2 compound deficiency redirects pancreatic alpha- and beta-cell differentiation to a somatostatin/ghrelin co-expressing cell lineage Activation of pancreatic-duct-derived progenitor cells during pancreas regeneration in adult rats Differentiation of pancreatic endocrine progenitors reversibly blocked by premature induction of MafA A novel molecular mechanism involved in multiple myeloma development revealed by targeting MafB to haematopoietic progenitors.Pax6 Inactivation in the Adult Pancreas Reveals Ghrelin as Endocrine Cell Maturation Marker Deconstructing pancreas developmental biology.Nutrient excess stimulates β-cell neogenesis in zebrafish.MafA is a dedicated activator of the insulin gene in vivo.p38 MAPK is a major regulator of MafA protein stability under oxidative stress.In vivo reprogramming of pancreatic acinar cells to three islet endocrine subtypes.MafA and MafB activity in pancreatic β cells.Glucagon gene expression in the endocrine pancreas: the role of the transcription factor Pax6 in α-cell differentiation, glucagon biosynthesis and secretion.Proper activation of MafA is required for optimal differentiation and maturation of pancreatic β-cells A synopsis of factors regulating beta cell development and beta cell mass.Role of large MAF transcription factors in the mouse endocrine pancreas.Expression of MafA in pancreatic progenitors is detrimental for pancreatic development.The stability and transactivation potential of the mammalian MafA transcription factor are regulated by serine 65 phosphorylation.MafB is critical for glucagon production and secretion in mouse pancreatic α-cells in vivo.MafB interacts with Gcm2 and regulates parathyroid hormone expression and parathyroid development.

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P2860

Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice.

http://www.wikidata.org/entity/Q39426103

description

2007 nî lūn-bûn

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2007年の論文

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年學術文章

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2007年學術文章

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2007年學術文章

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name

Preferential reduction of beta ...... athway in MafB deficient mice.

@en

Preferential reduction of beta ...... athway in MafB deficient mice.

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type

label

Preferential reduction of beta ...... athway in MafB deficient mice.

@en

Preferential reduction of beta ...... athway in MafB deficient mice.

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prefLabel

Preferential reduction of beta ...... athway in MafB deficient mice.

@en

Preferential reduction of beta ...... athway in MafB deficient mice.

@nl

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J.YDBIO.2007.12.00

J.YDBIO.2007.12.009

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Developmental Biology

P1476

Preferential reduction of beta ...... pathway in MafB deficient mice

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P2093

Arun Sharma

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Richard L Maas

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Sheldon Rowan

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Susan Bonner-Weir

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Susan M Sell

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Therese Salameh

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P2860

MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene

The mouse segmentation gene kr encodes a novel basic domain-leucine zipper transcription factor

MafB is an interaction partner and repressor of Ets-1 that inhibits erythroid differentiation

Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA.

neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas

MafB is required for islet beta cell maturation

PAX6 gene dosage effect in a family with congenital cataracts, aniridia, anophthalmia and central nervous system defects

Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development

Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice

The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas

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443-456

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scholarly article

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10.1016/J.YDBIO.2007.12.00

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10.1016/J.YDBIO.2007.12.009

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2

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314

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Wataru Nishimura

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2007-12-23T00:00:00Z

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5652986

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18199433

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2435621

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