WT1 mutants reveal SRPK1 to be a downstream angiogenesis target by altering VEGF splicing.
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Splicing Regulation: A Molecular Device to Enhance Cancer Cell AdaptationSplicing Regulators and Their Roles in Cancer Biology and TherapyConnecting the speckles: Splicing kinases and their role in tumorigenesis and treatment responsePhosphorylation-mediated regulation of alternative splicing in cancerVascular Endothelial Growth Factor-A165b Is Protective and Restores Endothelial Glycocalyx in Diabetic NephropathySerine-arginine protein kinase 1 (SRPK1) inhibition as a potential novel targeted therapeutic strategy in prostate cancerPotential Antileukemia Effect and Structural Analyses of SRPK Inhibition by N-(2-(Piperidin-1-yl)-5-(Trifluoromethyl)Phenyl)Isonicotinamide (SRPIN340)Expression analysis of an evolutionarily conserved alternative splicing factor, Sfrs10, in age-related macular degenerationRolling-circle transposons catalyze genomic innovation in a mammalian lineageBoth decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt.ABCC5 supports osteoclast formation and promotes breast cancer metastasis to bone.Vascular endothelial growth factor-A165b ameliorates outer-retinal barrier and vascular dysfunction in the diabetic retina.Metformin decreases progerin expression and alleviates pathological defects of Hutchinson-Gilford progeria syndrome cells.Targeting SRPK1 to control VEGF-mediated tumour angiogenesis in metastatic melanomaElevated SRPK1 lessens apoptosis in breast cancer cells through RBM4-regulated splicing events.Specific inhibition of serine/arginine-rich protein kinase attenuates choroidal neovascularization.The RNAissance family: SR proteins as multifaceted regulators of gene expressionAlternative splicing of TIA-1 in human colon cancer regulates VEGF isoform expression, angiogenesis, tumour growth and bevacizumab resistance.Detection of VEGF-A(xxx)b isoforms in human tissuesEpidermal growth-factor-induced transcript isoform variation drives mammary cell migration.Tumor cell migration screen identifies SRPK1 as breast cancer metastasis determinant.Inhibitors of CLK protein kinases suppress cell growth and induce apoptosis by modulating pre-mRNA splicingAlternative RNA splicing and cancerSerine-arginine protein kinase 1 promotes a cancer stem cell-like phenotype through activation of Wnt/β-catenin signalling in NSCLC.The Akt-SRPK-SR axis constitutes a major pathway in transducing EGF signaling to regulate alternative splicing in the nucleus.A summary of relationships between alternative splicing and breast cancer.VEGFA splicing: divergent isoforms regulate spermatogonial stem cell maintenance.The role of VEGF 165b in pathophysiologySerine-arginine protein kinase 1 (SRPK1), a determinant of angiogenesis, is upregulated in prostate cancer and correlates with disease stage and invasion.Oncogene- and drug resistance-associated alternative exon usage in acute myeloid leukemia (AML).Topical antiangiogenic SRPK1 inhibitors reduce choroidal neovascularization in rodent models of exudative AMDVEGF-A mRNA processing, stability and translation: a paradigm for intricate regulation of gene expression at the post-transcriptional level.Oncogenic alternative splicing switches: role in cancer progression and prospects for therapy.SRPK1 Dissimilarly Impacts on the Growth, Metastasis, Chemosensitivity and Angiogenesis of Glioma in Normoxic and Hypoxic Conditions.RNA splicing factors as oncoproteins and tumour suppressors.Phosphorylation of SRSF1 by SRPK1 regulates alternative splicing of tumor-related Rac1b in colorectal cells.Targeting the pro-angiogenic forms of VEGF or inhibiting their expression as anti-cancer strategies.WT1 expression in breast cancer disrupts the epithelial/mesenchymal balance of tumour cells and correlates with the metabolic response to docetaxel.SRPK1 inhibition in vivo: modulation of VEGF splicing and potential treatment for multiple diseases.Regulation of splicing by SR proteins and SR protein-specific kinases.
P2860
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P2860
WT1 mutants reveal SRPK1 to be a downstream angiogenesis target by altering VEGF splicing.
description
2011 nî lūn-bûn
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2011年の論文
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年学术文章
@zh-sg
2011年學術文章
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name
WT1 mutants reveal SRPK1 to be ...... get by altering VEGF splicing.
@en
WT1 mutants reveal SRPK1 to be ...... get by altering VEGF splicing.
@nl
type
label
WT1 mutants reveal SRPK1 to be ...... get by altering VEGF splicing.
@en
WT1 mutants reveal SRPK1 to be ...... get by altering VEGF splicing.
@nl
prefLabel
WT1 mutants reveal SRPK1 to be ...... get by altering VEGF splicing.
@en
WT1 mutants reveal SRPK1 to be ...... get by altering VEGF splicing.
@nl
P2093
P2860
P1433
P1476
WT1 mutants reveal SRPK1 to be ...... get by altering VEGF splicing.
@en
P2093
David O Bates
David R Hinton
Dawid G Nowak
Elianna M Amin
Emma S Rennel
Gavin I Welsh
Kirsty E Symonds
Man-Kim Cheung
P2860
P304
P356
10.1016/J.CCR.2011.10.016
P577
2011-12-01T00:00:00Z