Aberrant expression of RasGRP1 cooperates with gain-of-function NOTCH1 mutations in T-cell leukemogenesis.

Aberrant expression of RasGRP1 cooperates with gain-of-function NOTCH1 mutations in T-cell leukemogenesis.

Item
http://www.wikidata.org/entity/Q39437389
Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1Functional redundancy of Sos1 and Sos2 for lymphopoiesis and organismal homeostasis and survivalGene expression profiling of murine T-cell lymphoblastic lymphoma identifies deregulation of S-phase initiating genes.Dysregulated choline metabolism in T-cell lymphoma: role of choline kinase-α and therapeutic targeting.Regulation of ras exchange factors and cellular localization of ras activation by lipid messengers in T cells.RasGRP Ras guanine nucleotide exchange factors in cancer.The role of wild type RAS isoforms in cancer.A novel cell-cycle-indicator, mVenus-p27K-, identifies quiescent cells and visualizes G0-G1 transitionDysregulated RasGRP1 responds to cytokine receptor input in T cell leukemogenesisRasGRP1 overexpression in T-ALL increases basal nucleotide exchange on Ras rendering the Ras/PI3K/Akt pathway responsive to protumorigenic cytokines.Distinct oncogenic Ras signals characterized by profound differences in flux through the RasGDP/RasGTP cycleMEK and PI3K-AKT inhibitors synergistically block activated IL7 receptor signaling in T-cell acute lymphoblastic leukemia.A Forward Genetic Screen Targeting the Endothelium Reveals a Regulatory Role for the Lipid Kinase Pi4ka in Myelo- and Erythropoiesis.Comprehensive analysis of T cell leukemia signals reveals heterogeneity in the PI3 kinase-Akt pathway and limitations of PI3 kinase inhibitors as monotherapy.
P2860

Aberrant expression of RasGRP1 cooperates with gain-of-function NOTCH1 mutations in T-cell leukemogenesis.

Item
http://www.wikidata.org/entity/Q39437389
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh
2011年學術文章
@zh-hant
name
Aberrant expression of RasGRP1 ...... ions in T-cell leukemogenesis.
@en
Aberrant expression of RasGRP1 ...... ions in T-cell leukemogenesis.
@nl
type
label
Aberrant expression of RasGRP1 ...... ions in T-cell leukemogenesis.
@en
Aberrant expression of RasGRP1 ...... ions in T-cell leukemogenesis.
@nl
prefLabel
Aberrant expression of RasGRP1 ...... ions in T-cell leukemogenesis.
@en
Aberrant expression of RasGRP1 ...... ions in T-cell leukemogenesis.
@nl
P1433
P1476
P2093
P2860
P2888
P304
P31
P356
P433
P478
P577
P5875
P6179
P698
P356
P1433
P1476
Aberrant expression of RasGRP1 ...... ions in T-cell leukemogenesis.
@en
P2093
P2860
P2888
P304
P31
P356
P433
P478
P577
P5875
P6179
P698