Dysregulated RasGRP1 responds to cytokine receptor input in T cell leukemogenesis
about
Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1Diacylglycerol Kinases (DGKs): Novel Targets for Improving T Cell Activity in CancerComprehensive functional characterization of cancer-testis antigens defines obligate participation in multiple hallmarks of cancerDiacylglycerol Kinase ζ Limits Cytokine-dependent Expansion of CD8+ T Cells with Broad Antitumor Capacity.RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth.RasGRP1 promotes amphetamine-induced motor behavior through a Rhes interaction network ("Rhesactome") in the striatum.Single cell heterogeneity: why unstable genomes are incompatible with average profiles.Regulation of ras exchange factors and cellular localization of ras activation by lipid messengers in T cells.RasGRP Ras guanine nucleotide exchange factors in cancer.Ras activation revisited: role of GEF and GAP systems.Protein kinase C in cancer: The top five unanswered questions.Cutting Edge: Codeletion of the Ras GTPase-Activating Proteins (RasGAPs) Neurofibromin 1 and p120 RasGAP in T Cells Results in the Development of T Cell Acute Lymphoblastic Leukemia.RasGRP1 overexpression in T-ALL increases basal nucleotide exchange on Ras rendering the Ras/PI3K/Akt pathway responsive to protumorigenic cytokines.Distinct oncogenic Ras signals characterized by profound differences in flux through the RasGDP/RasGTP cycleA Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1.PLC-γ and PI3K link cytokines to ERK activation in hematopoietic cells with normal and oncogenic KrasBiochemical heterogeneity and developmental varieties in T-cell leukemia.Comprehensive analysis of T cell leukemia signals reveals heterogeneity in the PI3 kinase-Akt pathway and limitations of PI3 kinase inhibitors as monotherapy.Therapeutic Targeting of mTOR in T-Cell Acute Lymphoblastic Leukemia: An Update
P2860
Q24313621-EF7C53CD-31CA-42DD-8041-919CB9F98C1FQ28069966-435D79D7-4391-42DC-85F6-ACA857D9F9E0Q28975773-D74F8480-853A-4472-9002-961953A99EA5Q33715829-C71F765F-787F-45D4-9475-ABA143F3F863Q36299502-16003873-28F7-41F7-9E73-7A40EAD58D2DQ37482165-E642FC26-241F-43B8-BE92-3FB023DF2792Q37521396-CCD406F3-3CB7-480F-A123-4AD8DE529785Q38136655-9BD2C5B6-FAA6-419F-8FD6-C71BA3FD1CF5Q38205441-CA425B3C-64CE-451D-9F74-4E9C84CBBAB3Q38381506-590BEB69-04A7-4D2D-9016-D549D35D3523Q39098659-48829F9C-BAA7-47F1-BEE2-32848905423AQ41721282-A61B7BF0-C657-4044-BF57-27737460BC20Q42237019-080EC674-F10D-4679-A920-08B1F28246D3Q42319027-A29A1E41-2C81-4FB4-80CF-3747896B6756Q42378721-119A68F9-DAA7-4B79-9734-EFF595581558Q42760471-FD0A4E04-DA21-42A0-AF6A-4130AF5C936AQ43128980-F9B77DA5-AAC1-40BA-8C68-880A8DD48690Q54978251-58C98A1C-549C-4E4F-897A-1CDA979FF832Q56378380-47012E87-144C-4824-BA2C-EE60DE50A81F
P2860
Dysregulated RasGRP1 responds to cytokine receptor input in T cell leukemogenesis
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年学术文章
@wuu
2013年学术文章
@zh-cn
2013年学术文章
@zh-hans
2013年学术文章
@zh-my
2013年学术文章
@zh-sg
2013年學術文章
@yue
2013年學術文章
@zh
2013年學術文章
@zh-hant
name
Dysregulated RasGRP1 responds to cytokine receptor input in T cell leukemogenesis
@en
Dysregulated RasGRP1 responds to cytokine receptor input in T cell leukemogenesis.
@nl
type
label
Dysregulated RasGRP1 responds to cytokine receptor input in T cell leukemogenesis
@en
Dysregulated RasGRP1 responds to cytokine receptor input in T cell leukemogenesis.
@nl
prefLabel
Dysregulated RasGRP1 responds to cytokine receptor input in T cell leukemogenesis
@en
Dysregulated RasGRP1 responds to cytokine receptor input in T cell leukemogenesis.
@nl
P2093
P2860
P1433
P1476
Dysregulated RasGRP1 responds to cytokine receptor input in T cell leukemogenesis
@en
P2093
Anne Boeter
Arup K Chakraborty
Catherine Hartzell
Christopher Govern
Ed Lemmens
Jeroen Bakker
Jeroen P Roose
Kevin Shannon
Kristen Coakley
Kristin Ammon
P2860
P356
10.1126/SCISIGNAL.2003848
P577
2013-03-26T00:00:00Z