Pim kinase inhibitors sensitize prostate cancer cells to apoptosis triggered by Bcl-2 family inhibitor ABT-737.
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Cancer Microenvironment and Endoplasmic Reticulum Stress ResponseA small-molecule inhibitor of PIM kinases as a potential treatment for urothelial carcinomasTargeting Pim kinases for cancer treatment: opportunities and challengesPI3K and cancer: lessons, challenges and opportunitiesPIM kinases as potential therapeutic targets in a subset of peripheral T cell lymphoma cases.Cellular and molecular mechanisms underlie the anti-tumor activities exerted by Walterinnesia aegyptia venom combined with silica nanoparticles against multiple myeloma cancer cell types.Cafestol overcomes ABT-737 resistance in Mcl-1-overexpressed renal carcinoma Caki cells through downregulation of Mcl-1 expression and upregulation of Bim expression.Altered expression profile of apoptosis-related molecules correlated with clinicopathological factors in non-small-cell lung cancer.The PIM inhibitor AZD1208 synergizes with ruxolitinib to induce apoptosis of ruxolitinib sensitive and resistant JAK2-V617F-driven cells and inhibit colony formation of primary MPN cells.Combination of Pim kinase inhibitors and Bcl-2 antagonists in chronic lymphocytic leukemia cellsIntrinsic resistance to PIM kinase inhibition in AML through p38α-mediated feedback activation of mTOR signalingCHES1/FOXN3 regulates cell proliferation by repressing PIM2 and protein biosynthesis.Prostate cancer and the unfolded protein response.The PIM family of serine/threonine kinases in cancer.PIM kinase (and Akt) biology and signaling in tumors.Noxa and cancer therapy: Tuning up the mitochondrial death machinery in response to chemotherapy.Pim kinase isoforms: devils defending cancer cells from therapeutic and immune attacks.Inhibition of oncogenic Pim-3 kinase modulates transformed growth and chemosensitizes pancreatic cancer cells to gemcitabine.Snake (Walterinnesia aegyptia) venom-loaded silica nanoparticles induce apoptosis and growth arrest in human prostate cancer cells.Pim1 kinase regulates c-Kit gene translation.BH3 Mimetics for the Treatment of Prostate Cancer.Insulin receptor substrate 1 is a substrate of the Pim protein kinases.Deletion of Pim kinases elevates the cellular levels of reactive oxygen species and sensitizes to K-Ras-induced cell killing.Understanding sensitivity to BH3 mimetics: ABT-737 as a case study to foresee the complexities of personalized medicine.Rational cotargeting of Pim-1 and Akt in prostate cancer.Synergistic cytotoxicity of a prostate cancer-specific immunotoxin in combination with the BH3 mimetic ABT-737.Glycycoumarin Sensitizes Liver Cancer Cells to ABT-737 by Targeting De Novo Lipogenesis and TOPK-Survivin Axis.PIM-2 protein kinase negatively regulates T cell responses in transplantation and tumor immunity.Corosolic acid, a natural triterpenoid, induces ER stress-dependent apoptosis in human castration resistant prostate cancer cells via activation of IRE-1/JNK, PERK/CHOP and TRIB3
P2860
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P2860
Pim kinase inhibitors sensitize prostate cancer cells to apoptosis triggered by Bcl-2 family inhibitor ABT-737.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
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2011年學術文章
@zh-hant
name
Pim kinase inhibitors sensitiz ...... cl-2 family inhibitor ABT-737.
@en
Pim kinase inhibitors sensitiz ...... cl-2 family inhibitor ABT-737.
@nl
type
label
Pim kinase inhibitors sensitiz ...... cl-2 family inhibitor ABT-737.
@en
Pim kinase inhibitors sensitiz ...... cl-2 family inhibitor ABT-737.
@nl
prefLabel
Pim kinase inhibitors sensitiz ...... cl-2 family inhibitor ABT-737.
@en
Pim kinase inhibitors sensitiz ...... cl-2 family inhibitor ABT-737.
@nl
P2860
P1433
P1476
Pim kinase inhibitors sensitiz ...... cl-2 family inhibitor ABT-737.
@en
P2093
Andrew S Kraft
Jin H Song
P2860
P304
P356
10.1158/0008-5472.CAN-11-3240
P407
P577
2011-11-11T00:00:00Z