The PIM inhibitor AZD1208 synergizes with ruxolitinib to induce apoptosis of ruxolitinib sensitive and resistant JAK2-V617F-driven cells and inhibit colony formation of primary MPN cells.
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Potent Dual BET Bromodomain-Kinase Inhibitors as Value-Added Multitargeted Chemical Probes and Cancer Therapeutics.Ruxolitinib-induced defects in DNA repair cause sensitivity to PARP inhibitors in myeloproliferative neoplasms.Ruxolitinib combined with vorinostat suppresses tumor growth and alters metabolic phenotype in hematological diseases.Metformin exerts multitarget antileukemia activity in JAK2V617F-positive myeloproliferative neoplasms.FLT3-ITD induces expression of Pim kinases through STAT5 to confer resistance to the PI3K/Akt pathway inhibitors on leukemic cells by enhancing the mTORC1/Mcl-1 pathway.Novel Therapies for Myelofibrosis.Preclinical characterization of INCB053914, a novel pan-PIM kinase inhibitor, alone and in combination with anticancer agents, in models of hematologic malignancies.
P2860
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P2860
The PIM inhibitor AZD1208 synergizes with ruxolitinib to induce apoptosis of ruxolitinib sensitive and resistant JAK2-V617F-driven cells and inhibit colony formation of primary MPN cells.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
The PIM inhibitor AZD1208 syne ...... ormation of primary MPN cells.
@ast
The PIM inhibitor AZD1208 syne ...... ormation of primary MPN cells.
@en
type
label
The PIM inhibitor AZD1208 syne ...... ormation of primary MPN cells.
@ast
The PIM inhibitor AZD1208 syne ...... ormation of primary MPN cells.
@en
prefLabel
The PIM inhibitor AZD1208 syne ...... ormation of primary MPN cells.
@ast
The PIM inhibitor AZD1208 syne ...... ormation of primary MPN cells.
@en
P2093
P2860
P356
P1433
P1476
The PIM inhibitor AZD1208 syne ...... ormation of primary MPN cells.
@en
P2093
Anuradha Pradhan
Dennis Huszar
Gary W Reuther
Lori N Griner
Que T Lambert
P2860
P304
40141-40157
P356
10.18632/ONCOTARGET.5653
P407
P577
2015-10-12T00:00:00Z