Macromolecular assembly-driven processing of the 2/3 cleavage site in the alphavirus replicase polyprotein.
about
Mutations conferring a noncytotoxic phenotype on chikungunya virus replicons compromise enzymatic properties of nonstructural protein 2Functional cross-talk between distant domains of chikungunya virus non-structural protein 2 is decisive for its RNA-modulating activityAlphavirus RNA synthesis and non-structural protein functionsDifferences in Processing Determinants of Nonstructural Polyprotein and in the Sequence of Nonstructural Protein 3 Affect Neurovirulence of Semliki Forest VirusStructural and functional insights into alphavirus polyprotein processing and pathogenesisSequestration of G3BP coupled with efficient translation inhibits stress granules in Semliki Forest virus infectionControl of the rescue and replication of Semliki Forest virus recombinants by the insertion of miRNA target sequences.A conserved NS3 surface patch orchestrates NS2 protease stimulation, NS5A hyperphosphorylation and HCV genome replication.Full length and protease domain activity of chikungunya virus nsP2 differ from other alphavirus nsP2 proteases in recognition of small peptide substrates.Versatile Trans-Replication Systems for Chikungunya Virus Allow Functional Analysis and Tagging of Every Replicase Protein.Chikungunya nsP2 protease is not a papain-like cysteine protease and the catalytic dyad cysteine is interchangeable with a proximal serine.Presentation overrides specificity: probing the plasticity of alphaviral proteolytic activity through mutational analysis.Design and Validation of Novel Chikungunya Virus Protease Inhibitors.Inhibition of host protein synthesis by Sindbis virus: correlation with viral RNA replication and release of nuclear proteins to the cytoplasm.Hypervariable domain of nonstructural protein nsP3 of Venezuelan equine encephalitis virus determines cell-specific mode of virus replication.Hypervariable domains of nsP3 proteins of New World and Old World alphaviruses mediate formation of distinct, virus-specific protein complexes.Chikungunya virus infectivity, RNA replication and non-structural polyprotein processing depend on the nsP2 protease's active site cysteine residue.Viral Macrodomains: Unique Mediators of Viral Replication and Pathogenesis.Chikungunya virus nsP1 interacts directly with nsP2 and modulates its ATPase activity.The Regulation of Translation in Alphavirus-Infected Cells.A Chikungunya virus trans-replicase system reveals the importance of delayed non-structural polyprotein processing for efficient replication complex formation in mosquito cells.Timeliness of proteolytic events is prerequisite for efficient functioning of the alphaviral replicase.The Enigmatic Alphavirus Non-Structural Protein 3 (nsP3) Revealing Its Secrets at Last.Mayaro virus: a neglected arbovirus of the AmericasDecreased Virulence of Ross River Virus Harboring a Mutation in the First Cleavage Site of Nonstructural Polyprotein Is Caused by a Novel Mechanism Leading to Increased Production of Interferon-Inducing RNAs
P2860
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P2860
Macromolecular assembly-driven processing of the 2/3 cleavage site in the alphavirus replicase polyprotein.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh
2011年學術文章
@zh-hant
name
Macromolecular assembly-driven ...... havirus replicase polyprotein.
@en
Macromolecular assembly-driven ...... havirus replicase polyprotein.
@nl
type
label
Macromolecular assembly-driven ...... havirus replicase polyprotein.
@en
Macromolecular assembly-driven ...... havirus replicase polyprotein.
@nl
prefLabel
Macromolecular assembly-driven ...... havirus replicase polyprotein.
@en
Macromolecular assembly-driven ...... havirus replicase polyprotein.
@nl
P2860
P50
P356
P1433
P1476
Macromolecular assembly-driven ...... havirus replicase polyprotein.
@en
P2860
P304
P356
10.1128/JVI.05195-11
P407
P577
2011-10-26T00:00:00Z