A structural model of the tetrodotoxin and saxitoxin binding site of the Na+ channel.
about
Specific neosaxitoxin interactions with the Na+ channel outer vestibule determined by mutant cycle analysis.Cooccupancy of the outer vestibule of voltage-gated sodium channels by micro-conotoxin KIIIA and saxitoxin or tetrodotoxinThe chemical and evolutionary ecology of tetrodotoxin (TTX) toxicity in terrestrial vertebratesThe hitchhiker's guide to the voltage-gated sodium channel galaxyFrom foe to friend: using animal toxins to investigate ion channel functionTheoretical and simulation studies on voltage-gated sodium channelsSubdiffusion and Anomalous Local Viscoelasticity in Actin NetworksA molecular switch between the outer and the inner vestibules of the voltage-gated Na+ channelUltra-slow inactivation in mu1 Na+ channels is produced by a structural rearrangement of the outer vestibuleStructure of the sodium channel pore revealed by serial cysteine mutagenesis.Temporally and spectrally resolved subpicosecond energy transfer within the peripheral antenna complex (LH2) and from LH2 to the core antenna complex in photosynthetic purple bacteria.Molecular determinants of drug access to the receptor site for antiarrhythmic drugs in the cardiac Na+ channel.Sodium channel selectivity filter regulates antiarrhythmic drug bindingA structural motif for the voltage-gated potassium channel pore.Topology of the P segments in the sodium channel pore revealed by cysteine mutagenesisMolecular motions within the pore of voltage-dependent sodium channelsAtomic distance estimates from disulfides and high-affinity metal-binding sites in a K+ channel pore.Shaker pore structure as predicted by annealed atomic simulation using symmetry and novel geometric restraintsDifferential effects of sulfhydryl reagents on saxitoxin and tetrodotoxin block of voltage-dependent Na channels.Use dependence of tetrodotoxin block of sodium channels: a revival of the trapped-ion mechanism.Solvation, water permeation, and ionic selectivity of a putative model for the pore region of the voltage-gated sodium channel.On the structural basis for ionic selectivity among Na+, K+, and Ca2+ in the voltage-gated sodium channel.Subnanosecond polarized fluorescence photobleaching: rotational diffusion of acetylcholine receptors on developing muscle cells.A mu-conotoxin-insensitive Na+ channel mutant: possible localization of a binding site at the outer vestibule.Glutamate substitution in repeat IV alters divalent and monovalent cation permeation in the heart Ca2+ channel.Post-repolarization block of cloned sodium channels by saxitoxin: the contribution of pore-region amino acids.Trimethyloxonium modification of batrachotoxin-activated Na channels alters functionally important protein residuesA mutation in the pore of the sodium channel alters gating.Differences in saxitoxin and tetrodotoxin binding revealed by mutagenesis of the Na+ channel outer vestibule.The forward rate of binding of surface-tethered reactants: effect of relative motion between two surfacesSurface-induced polymerization of actin.Tonic and phasic tetrodotoxin block of sodium channels with point mutations in the outer pore regionNovel interactions identified between micro -Conotoxin and the Na+ channel domain I P-loop: implications for toxin-pore binding geometry.Structure and function of voltage-gated sodium channels.Toxic marine dinoflagellates in Singapore waters that cause seafood poisonings.Bacterial voltage-gated sodium channels (BacNa(V)s) from the soil, sea, and salt lakes enlighten molecular mechanisms of electrical signaling and pharmacology in the brain and heart.A critical residue for isoform difference in tetrodotoxin affinity is a molecular determinant of the external access path for local anesthetics in the cardiac sodium channel.Docking of mu-conotoxin GIIIA in the sodium channel outer vestibule.A human colon carcinoma cell line exhibits adhesive interactions with P-selectin under fluid flow via a PSGL-1-independent mechanism.Compound heterozygous mutations P336L and I1660V in the human cardiac sodium channel associated with the Brugada syndrome.
P2860
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P2860
A structural model of the tetrodotoxin and saxitoxin binding site of the Na+ channel.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年学术文章
@wuu
1994年学术文章
@zh-cn
1994年学术文章
@zh-hans
1994年学术文章
@zh-my
1994年学术文章
@zh-sg
1994年學術文章
@yue
1994年學術文章
@zh
1994年學術文章
@zh-hant
name
A structural model of the tetrodotoxin and saxitoxin binding site of the Na+ channel.
@en
A structural model of the tetrodotoxin and saxitoxin binding site of the Na+ channel.
@nl
type
label
A structural model of the tetrodotoxin and saxitoxin binding site of the Na+ channel.
@en
A structural model of the tetrodotoxin and saxitoxin binding site of the Na+ channel.
@nl
prefLabel
A structural model of the tetrodotoxin and saxitoxin binding site of the Na+ channel.
@en
A structural model of the tetrodotoxin and saxitoxin binding site of the Na+ channel.
@nl
P2860
P1433
P1476
A structural model of the tetrodotoxin and saxitoxin binding site of the Na+ channel.
@en
P2093
G M Lipkind
H A Fozzard
P2860
P356
10.1016/S0006-3495(94)80746-5
P407
P577
1994-01-01T00:00:00Z