Differences in saxitoxin and tetrodotoxin binding revealed by mutagenesis of the Na+ channel outer vestibule.
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Specific neosaxitoxin interactions with the Na+ channel outer vestibule determined by mutant cycle analysis.Genetic architecture of a feeding adaptation: garter snake (Thamnophis) resistance to tetrodotoxin bearing preyCooccupancy of the outer vestibule of voltage-gated sodium channels by micro-conotoxin KIIIA and saxitoxin or tetrodotoxinThe chemical and evolutionary ecology of tetrodotoxin (TTX) toxicity in terrestrial vertebratesThe evolutionary origins of beneficial alleles during the repeated adaptation of garter snakes to deadly prey.Theoretical and simulation studies on voltage-gated sodium channelsTwo tetrodotoxin-resistant sodium channels in human dorsal root ganglion neuronsEvolutionary history of a complex adaptation: tetrodotoxin resistance in salamanders.Parallel evolution of tetrodotoxin resistance in three voltage-gated sodium channel genes in the garter snake Thamnophis sirtalis.Constraint shapes convergence in tetrodotoxin-resistant sodium channels of snakesToxin-resistant sodium channels: parallel adaptive evolution across a complete gene family.Energetic localization of saxitoxin in its channel binding site.μ-conotoxin KIIIA derivatives with divergent affinities versus efficacies in blocking voltage-gated sodium channels.Interactions of the C-11 hydroxyl of tetrodotoxin with the sodium channel outer vestibuleNovel interactions identified between micro -Conotoxin and the Na+ channel domain I P-loop: implications for toxin-pore binding geometry.Role of Na(v)1.9 in activity-dependent axon growth in motoneurons.Bacterial voltage-gated sodium channels (BacNa(V)s) from the soil, sea, and salt lakes enlighten molecular mechanisms of electrical signaling and pharmacology in the brain and heart.Calcium block of single sodium channels: role of a pore-lining aromatic residueThree-dimensional modelling of the voltage-gated sodium ion channel from Anopheles gambiae reveals spatial clustering of evolutionarily conserved acidic residues at the extracellular sites.Use-dependent block of the voltage-gated Na(+) channel by tetrodotoxin and saxitoxin: effect of pore mutations that change ionic selectivity.Marked difference in saxitoxin and tetrodotoxin affinity for the human nociceptive voltage-gated sodium channel (Nav1.7) [corrected]Molecular architecture of the voltage-dependent Na channel: functional evidence for alpha helices in the pore.Differential interactions of Na+ channel toxins with T-type Ca2+ channels.Mutant cycle analysis with modified saxitoxins reveals specific interactions critical to attaining high-affinity inhibition of hNaV1.7.Voltage-gated sodium channel blockers for the treatment of neuropathic pain.Voltage-gated Na channel selectivity: the role of the conserved domain III lysine residueThe tetrodotoxin binding site is within the outer vestibule of the sodium channel.The outer vestibule of the Na+ channel-toxin receptor and modulator of permeation as well as gating.Saxitoxin.Tonic and phasic guanidinium toxin-block of skeletal muscle Na channels expressed in Mammalian cells.Isoform-dependent interaction of voltage-gated sodium channels with protons.Modeling P-loops domain of sodium channel: homology with potassium channels and interaction with ligands.Saxitoxin is a gating modifier of HERG K+ channels.The cation selectivity filter of the bacterial sodium channel, NaChBac.Conotoxins as sensors of local pH and electrostatic potential in the outer vestibule of the sodium channel.Low concentrations of tetrodotoxin interact with tetrodotoxin-resistant voltage-gated sodium channels.Thermal and chemical unfolding and refolding of a eukaryotic sodium channelAn evolutionarily-unique heterodimeric voltage-gated cation channel found in aphids.Role of amino acid residues in transmembrane segments IS6 and IIS6 of the Na+ channel alpha subunit in voltage-dependent gating and drug block.Role of outer ring carboxylates of the rat skeletal muscle sodium channel pore in proton block.
P2860
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P2860
Differences in saxitoxin and tetrodotoxin binding revealed by mutagenesis of the Na+ channel outer vestibule.
description
1998 nî lūn-bûn
@nan
1998 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Differences in saxitoxin and t ...... e Na+ channel outer vestibule.
@ast
Differences in saxitoxin and t ...... e Na+ channel outer vestibule.
@en
Differences in saxitoxin and t ...... e Na+ channel outer vestibule.
@nl
type
label
Differences in saxitoxin and t ...... e Na+ channel outer vestibule.
@ast
Differences in saxitoxin and t ...... e Na+ channel outer vestibule.
@en
Differences in saxitoxin and t ...... e Na+ channel outer vestibule.
@nl
prefLabel
Differences in saxitoxin and t ...... e Na+ channel outer vestibule.
@ast
Differences in saxitoxin and t ...... e Na+ channel outer vestibule.
@en
Differences in saxitoxin and t ...... e Na+ channel outer vestibule.
@nl
P2093
P2860
P1433
P1476
Differences in saxitoxin and t ...... he Na+ channel outer vestibule
@en
P2093
G M Lipkind
H A Fozzard
J L Penzotti
P2860
P304
P356
10.1016/S0006-3495(98)77710-0
P407
P577
1998-12-01T00:00:00Z