Gain-of-function mutant p53 but not p53 deletion promotes head and neck cancer progression in response to oncogenic K-ras.
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Animal models to study the mutational landscape for oral cavity and oropharyngeal cancersMore targets, more pathways and more clues for mutant p53.Antiangiogenesis and gene aberration-related therapy may improve overall survival in patients with concurrent KRAS and TP53 hotspot mutant cancerAKT regulates NPM dependent ARF localization and p53mut stability in tumors.Molecular mechanism of mutant p53 stabilization: the role of HSP70 and MDM2.Loss of epithelial p53 and αv integrin cooperate through Akt to induce squamous cell carcinoma yet prevent remodeling of the tumor microenvironment.Comparison of effects of p53 null and gain-of-function mutations on salivary tumors in MMTV-Hras transgenic mice.Adenovirus replaces mitotic checkpoint controls.LSL-KrasG12D; LSL-Trp53R172H/+; Ink4flox/+; Ptf1/p48-Cre mice are an applicable model for locally invasive and metastatic pancreatic cancer.Mutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer.Differential regulation of the REGγ-proteasome pathway by p53/TGF-β signalling and mutant p53 in cancer cells.YAP enhances the pro-proliferative transcriptional activity of mutant p53 proteins.A tan in a test tube - in vitro models for investigating ultraviolet radiation-induced damage in skin.Molecular diagnostic alterations in squamous cell carcinoma of the head and neck and potential diagnostic applications.Mutant p53 in cancer: new functions and therapeutic opportunities.p53 and its mutants on the slippery road from stemness to carcinogenesis.TP53 Mutations in Head and Neck Squamous Cell Carcinoma and Their Impact on Disease Progression and Treatment Response.Expression of cyclin A, B1 and D1 after induction of cell cycle arrest in the Jurkat cell line exposed to doxorubicin.Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation.Proteomic identification of ERP29 as a key chemoresistant factor activated by the aggregating p53 mutant Arg282Trp.Hydroquinone induces TK6 cell growth arrest and apoptosis through PARP-1/p53 regulatory pathway.Long Non-coding MIR205HG Depletes Hsa-miR-590-3p Leading to Unrestrained Proliferation in Head and Neck Squamous Cell Carcinoma.Cdkn2a suppresses metastasis in squamous cell carcinomas induced by the gain-of-function mutant p53(R172H).
P2860
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P2860
Gain-of-function mutant p53 but not p53 deletion promotes head and neck cancer progression in response to oncogenic K-ras.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Gain-of-function mutant p53 bu ...... n response to oncogenic K-ras.
@en
type
label
Gain-of-function mutant p53 bu ...... n response to oncogenic K-ras.
@en
prefLabel
Gain-of-function mutant p53 bu ...... n response to oncogenic K-ras.
@en
P2093
P2860
P356
P1476
Gain-of-function mutant p53 bu ...... in response to oncogenic K-ras
@en
P2093
Adel K El-Naggar
Carlos Caulin
Dennis R Roop
Olga Mejia
Zhongyou Li
P2860
P304
P356
10.1002/PATH.2971
P50
P577
2011-09-26T00:00:00Z