Quinolone resistance mutations in Streptococcus pneumoniae GyrA and ParC proteins: mechanistic insights into quinolone action from enzymatic analysis, intracellular levels, and phenotypes of wild-type and mutant proteins.
about
Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerasesMycobacterium tuberculosis DNA gyrase: interaction with quinolones and correlation with antimycobacterial drug activityExploring the active site of the Streptococcus pneumoniae topoisomerase IV-DNA cleavage complex with novel 7,8-bridged fluoroquinolonesContribution of the ATP binding site of ParE to susceptibility to novobiocin and quinolones in Streptococcus pneumoniaeAssessing sensitivity to antibacterial topoisomerase II inhibitors.Novel Ser79Leu and Ser81Ile substitutions in the quinolone resistance-determining regions of ParC topoisomerase IV and GyrA DNA gyrase subunits from recent fluoroquinolone-resistant Streptococcus pneumoniae clinical isolatesMolecular Investigation of Quinolone Resistance of Quinolone Resistance-Determining Region in Streptococcus pneumoniae Strains Isolated from Iran Using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism Method.Contribution of the 8-methoxy group to the activity of gatifloxacin against type II topoisomerases of Streptococcus pneumoniae.Topoisomerase targeting with and resistance to gemifloxacin in Staphylococcus aureusOpposing effects of target overexpression reveal drug mechanismsAmino acid substitutions at position 95 in GyrA can add fluoroquinolone resistance to Mycobacterium leprae.ATP-bound conformation of topoisomerase IV: a possible target for quinolones in Streptococcus pneumoniaeMutagenesis in the alpha3alpha4 GyrA helix and in the Toprim domain of GyrB refines the contribution of Mycobacterium tuberculosis DNA gyrase to intrinsic resistance to quinolones.Mechanism of quinolone action and resistance.Grepafloxacin, a dimethyl derivative of ciprofloxacin, acts preferentially through gyrase in Streptococcus pneumoniae: role of the C-5 group in target specificity.Cleavable-complex formation by wild-type and quinolone-resistant Streptococcus pneumoniae type II topoisomerases mediated by gemifloxacin and other fluoroquinolones.Small-colony mutants of Staphylococcus aureus allow selection of gyrase-mediated resistance to dual-target fluoroquinolones.Impact of mutations in DNA gyrase genes on quinolone resistance in Campylobacter jejuni.Ciprofloxacin dimers target gyrase in Streptococcus pneumoniae.Functional determinants of gate-DNA selection and cleavage by bacterial type II topoisomerases.Impact of the E540V amino acid substitution in GyrB of Mycobacterium tuberculosis on quinolone resistanceProbing the differential interactions of quinazolinedione PD 0305970 and quinolones with gyrase and topoisomerase IVClerocidin selectively modifies the gyrase-DNA gate to induce irreversible and reversible DNA damage.Clerocidin interacts with the cleavage complex of Streptococcus pneumoniae topoisomerase IV to induce selective irreversible DNA damage.Evaluation of survival and pharmacodynamic relationships for five fluoroquinolones in a neutropenic murine model of pneumococcal lung infection.Prevalence of antimicrobial resistance among pigeon isolates of Streptococcus gallolyticus, Escherichia coli and Salmonella enterica serotype Typhimurium.Staphylococcus aureus gyrase-quinolone-DNA ternary complexes fail to arrest replication fork progression in vitro. Effects of salt on the DNA binding mode and the catalytic activity of S. aureus gyrase.Novel symmetric and asymmetric DNA scission determinants for Streptococcus pneumoniae topoisomerase IV and gyrase are clustered at the DNA breakage site.Double-Serine Fluoroquinolone Resistance Mutations Advance Major International Clones and Lineages of Various Multi-Drug Resistant Bacteria.Trapping of the transport-segment DNA by the ATPase domains of a type II topoisomerase.
P2860
Q27655501-15A6D09A-FB82-4B18-B21C-11091C114083Q28486793-95126AD7-86E1-46C8-AAC9-8932654072B2Q28828291-E1989F2E-4D5F-4E60-B27D-31963D1FFC0FQ33757558-05C409FD-8808-4338-9B82-7920DA959DE0Q33771873-ECE45AB6-A015-4010-AA65-23A215D9B49FQ33836603-1762C9F8-7C6D-425F-8CFD-ABAB429814C6Q34478323-F606BAE3-3BAB-4381-B7DA-480196BB5E89Q34721556-B0293EE7-A5E2-4ACC-9FC2-5DBA30252516Q34725095-32C16143-1EC4-4536-BAE2-179292D16791Q35535319-88E969BD-9316-44FC-A6F5-2FECFCF0F0ABQ35689265-5C530C50-1ACA-4FDA-BD9A-2BBF1A812419Q36474350-A77BCA1B-4340-403C-80A8-0B119EFFB2A2Q36804000-2776F345-318E-491E-950E-56120C216A05Q37701591-0234444E-32F9-459F-8792-2423405415BEQ39651301-A7F6F57A-BEA4-42E4-B13D-82E37277760CQ39651324-B1D30DB1-24FF-4C82-94A6-F8FDA6FDEB43Q39652375-E49CFD7F-C44C-4665-A711-F34BEBADC19DQ40799670-33BFB3A9-DC8E-413C-9AC3-740E873DD82AQ40882705-7D30FF41-069F-4F7C-9601-6A9BDF6D4A64Q41848451-851329E5-ED95-4D07-8C93-C4203513AB96Q42110958-2FA9679E-9FBF-4723-98B1-07AB4D8EDDF9Q42111571-AA3AADD9-86EA-44CE-9AFA-CDAEF7B72877Q42264322-CFBAF8F6-53DD-43AD-9F4B-980D93D3B5D1Q42872445-DC54A03C-C658-4CF9-8873-52B8F4B0A69FQ43951650-BEE952AE-1991-456C-AB34-BF928DA86A0EQ44151342-3265B222-0B7D-496B-8CE6-ACB6A18507F3Q44269063-58B6C5D0-6DD4-4087-A0FA-1A8FDD4C4A31Q45230495-7DBE2D6A-278B-4A40-9E6D-ED2C105538B8Q46237911-87F816D5-1158-4443-ACA0-A04546497AEEQ55518315-853F5E5E-356B-487C-826E-03E2C24B9999
P2860
Quinolone resistance mutations in Streptococcus pneumoniae GyrA and ParC proteins: mechanistic insights into quinolone action from enzymatic analysis, intracellular levels, and phenotypes of wild-type and mutant proteins.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
Quinolone resistance mutations ...... wild-type and mutant proteins.
@en
Quinolone resistance mutations ...... wild-type and mutant proteins.
@nl
type
label
Quinolone resistance mutations ...... wild-type and mutant proteins.
@en
Quinolone resistance mutations ...... wild-type and mutant proteins.
@nl
prefLabel
Quinolone resistance mutations ...... wild-type and mutant proteins.
@en
Quinolone resistance mutations ...... wild-type and mutant proteins.
@nl
P2093
P2860
P1476
Quinolone resistance mutations ...... wild-type and mutant proteins.
@en
P2093
P2860
P304
P356
10.1128/AAC.45.11.3140-3147.2001
P407
P577
2001-11-01T00:00:00Z