Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin - Wikidata - awgldk - TriplyDB

Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin

Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin

http://www.wikidata.org/entity/Q39497589

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A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B Cell division: control of the chromosomal passenger complex in time and space Phosphorylation of threonine 3 on histone H3 by haspin kinase is required for meiosis I in mouse oocytes Development of a Peptide that Selectively Activates Protein Phosphatase-1 in Living Cells Selectivity Profiling and Biological Activity of Novel β-Carbolines as Potent and Selective DYRK1 Kinase Inhibitors Chromatin condensation and recruitment of PHD finger proteins to histone H3K4me3 are mutually exclusive A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.Epigenetics: relevance and implications for public health Kinase Gene Expression Profiling of Metastatic Clear Cell Renal Cell Carcinoma Tissue Identifies Potential New Therapeutic Targets.Haspin inhibitors reveal centromeric functions of Aurora B in chromosome segregation Subamolide a induces mitotic catastrophe accompanied by apoptosis in human lung cancer cells On your histone mark, SET, methylate!Cancer Epigenetics for the 21st Century: What's Next?Optimization of arterial spin labeling MRI for quantitative tumor perfusion in a mouse xenograft model.Co-crystal structures of the protein kinase haspin with bisubstrate inhibitors.The XTT cell proliferation assay applied to cell layers embedded in three-dimensional matrix.Bromodomain inhibition shows antitumoral activity in mice and human luminal breast cancer.Anti-Melanoma Activities of Haspin Inhibitor CHR-6494 Deployed as a Single Agent or in a Synergistic Combination with MEK Inhibitor.Structure-activity relationship study of beta-carboline derivatives as haspin kinase inhibitors.Barcelona Conference on Epigenetics and Cancer: 50 years of histone acetylation.Cancer epigenetics: new therapies and new challenges.Involvement of autophagy in the outcome of mitotic catastrophe.Coumestrol Epigenetically Suppresses Cancer Cell Proliferation: Coumestrol Is a Natural Haspin Kinase Inhibitor.3H-pyrazolo[4,3-f]quinoline haspin kinase inhibitors and anticancer properties.DMXAA (Vadimezan, ASA404) is a multi-kinase inhibitor targeting VEGFR2 in particular.AKT kinase pathway: a leading target in cancer research.

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P2860

Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin

http://www.wikidata.org/entity/Q39497589

description

2011 nî lūn-bûn

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2011年の論文

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2011年学术文章

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2011年学术文章

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2011年学术文章

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2011年学术文章

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2011年学术文章

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2011年學術文章

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2011年學術文章

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2011年學術文章

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name

Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin

@en

Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin.

@nl

type

label

Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin

@en

Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin.

@nl

prefLabel

Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin

@en

Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin.

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Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin

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A Villanueva

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D Brotherton

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D Huertas

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D Krige

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D Moffat

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M Charlton

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M Soler

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P2860

The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment

Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis.

The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction.

Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia

Reversine, a novel Aurora kinases inhibitor, inhibits colony formation of human acute myeloid leukemia cells

Crystal structure of the catalytic domain of Haspin, an atypical kinase implicated in chromatin organization

Structure and functional characterization of the atypical human kinase haspin

The spindle-assembly checkpoint in space and time

Chromatin modifications and their function

The epigenomics of cancer

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