Metronidazole activation is mutagenic and causes DNA fragmentation in Helicobacter pylori and in Escherichia coli containing a cloned H. pylori RdxA(+) (Nitroreductase) gene.
about
Helicobacter pylori mutants defective in RuvC Holliday junction resolvase display reduced macrophage survival and spontaneous clearance from the murine gastric mucosaNitroimidazoles for the treatment of TB: past, present and futurePeripheral glia have a pivotal role in the initial response to axon degeneration of peripheral sensory neurons in zebrafishStructure of RdxA--an oxygen-insensitive nitroreductase essential for metronidazole activation in Helicobacter pyloriAspirin inhibits the growth of Helicobacter pylori and enhances its susceptibility to antimicrobial agentsEnzymes associated with reductive activation and action of nitazoxanide, nitrofurans, and metronidazole in Helicobacter pylori.Point mutations in Helicobacter pylori's fur regulatory gene that alter resistance to metronidazole, a prodrug activated by chemical reductionIdentification of a Mycobacterium tuberculosis putative classical nitroreductase gene whose expression is coregulated with that of the acr aene within macrophages, in standing versus shaking cultures, and under low oxygen conditions.Synthesis and Antimicrobial Evaluation of Amixicile-Based Inhibitors of the Pyruvate-Ferredoxin Oxidoreductases of Anaerobic Bacteria and Epsilonproteobacteria.Preclinical studies of amixicile, a systemic therapeutic developed for treatment of Clostridium difficile infections that also shows efficacy against Helicobacter pyloriResponse to metronidazole and oxidative stress is mediated through homeostatic regulator HsrA (HP1043) in Helicobacter pylori.Characterization of the NAD(P)H oxidase and metronidazole reductase activities of the RdxA nitroreductase of Helicobacter pylori.Antiparasitic drug nitazoxanide inhibits the pyruvate oxidoreductases of Helicobacter pylori, selected anaerobic bacteria and parasites, and Campylobacter jejuni.Flavodoxin:quinone reductase (FqrB): a redox partner of pyruvate:ferredoxin oxidoreductase that reversibly couples pyruvate oxidation to NADPH production in Helicobacter pylori and Campylobacter jejuni.Functional analysis of the RdxA and RdxB nitroreductases of Campylobacter jejuni reveals that mutations in rdxA confer metronidazole resistanceDNA sequence analysis of rdxA and frxA from 12 pairs of metronidazole-sensitive and -resistant clinical Helicobacter pylori isolates.Sequential inactivation of rdxA (HP0954) and frxA (HP0642) nitroreductase genes causes moderate and high-level metronidazole resistance in Helicobacter pyloriRoles of FrxA and RdxA nitroreductases of Helicobacter pylori in susceptibility and resistance to metronidazole.Superoxide dismutase-deficient mutants of Helicobacter pylori are hypersensitive to oxidative stress and defective in host colonization.Helicobacter pylori primary resistance to metronidazole and clarithromycin in Brazil.Diverse phenotypes resulting from polyphosphate kinase gene (ppk1) inactivation in different strains of Helicobacter pyloriAnalysis of clinical isolates of Helicobacter pylori in Pakistan reveals high degrees of pathogenicity and high frequencies of antibiotic resistance.Mutations in the 16S rRNA genes of Helicobacter pylori mediate resistance to tetracycline.Evidence for induction of integron-based antibiotic resistance by the SOS response in a clinical setting.Bacteroides fragilis RecA protein overexpression causes resistance to metronidazoleCharacterization of a stable, metronidazole-resistant Clostridium difficile clinical isolateReactivity of reduced [2Fe-2S] ferredoxins parallels host susceptibility to nitroimidazolesInteractions with iridophores and the tissue environment required for patterning melanophores and xanthophores during zebrafish adult pigment stripe formation.Antibiotic susceptibility profile of Helicobacter pylori isolated from the dyspepsia patients in Tehran, IranWho's Winning the War? Molecular Mechanisms of Antibiotic Resistance in Helicobacter pyloriPhenotypic and transcriptional profiling in Entamoeba histolytica reveal costs to fitness and adaptive responses associated with metronidazole resistanceMutations in Helicobacter pylori porD and oorD genes may contribute to furazolidone resistanceAntimicrobial susceptibility and resistance patterns among Helicobacter pylori strains from The Gambia, West Africa.Collateral effects of antibiotics: carbadox and metronidazole induce VSH-1 and facilitate gene transfer among Brachyspira hyodysenteriae strains.Comparative characterisation of two nitroreductases from Giardia lamblia as potential activators of nitro compounds.Exploratory Investigation of Bacteroides fragilis Transcriptional Response during In vitro Exposure to Subinhibitory Concentration of Metronidazole.Proteomic analysis of a NAP1 Clostridium difficile clinical isolate resistant to metronidazole.Mechanisms of Antibacterial Action of Quinoxaline 1,4-di-N-oxides against Clostridium perfringens and Brachyspira hyodysenteriae.Molecular and Proteomic Analysis of Levofloxacin and Metronidazole Resistant Helicobacter pylori.Antimicrobial susceptibility of Helicobacter pylori strains isolated in Bangladesh
P2860
Q24554445-76DAD66B-4F98-42EE-BFD0-124F1EF2595EQ26849554-A9C57F6F-6132-4F8D-B521-05DEB2E26359Q27317497-204734E5-435C-43B4-9915-ED55A5ED7D8DQ27674271-749367B9-D8DB-4005-BA7A-049F96D0BC05Q28195352-E045AFE1-85BE-4D12-BB43-D2FE1E84EE31Q28205159-9A4989D5-B7C5-4511-8436-9E2C3B44D135Q28477525-A8DA1DB8-7591-4D6A-BA40-782111F4C7D4Q28486565-F9A9A0F4-8045-4AD5-9B40-AD2F33057954Q30276966-1CFC6A10-A579-44D6-BAC7-0F6A41425E22Q30408277-2BBE130F-EC72-4AEA-AD7A-5BA489449F02Q30411563-362CE32B-D5B7-4122-A4DF-50F47B15C3ABQ30437743-60ADA96E-C241-444B-8EAF-B88DF6EAE093Q30442308-E3AF67E1-EE8C-4953-8C19-67FD0EBA64BEQ30443522-05953940-CE37-4BB9-A7C0-429EF36C7D25Q33725381-5DBEE340-1BD1-49CC-9FE5-D2C4BB191F84Q33982967-21495D75-A68E-4425-97A7-576BFD0C4AC8Q33994585-BA8F0AA5-28D0-4F8E-8D2B-1263C677D3A3Q33996752-C9E88833-D583-4D4F-8EDE-BCE99EF4CD91Q34008070-EE1EC6A2-A2C8-4ECA-B5F4-64AD71AC5860Q34109053-FF4A9B25-29F1-443A-BC9B-53D228153D10Q34124303-CA3A2415-6070-403E-84AA-7F512B837F83Q34173782-E4C6AFDB-BDE3-43D8-B98D-EBA19E47E631Q34309350-88A50C8D-8EB8-4D47-8301-2143DAE92054Q34311588-FFB4BA01-064B-4AB3-AC01-168FFA69A210Q34512611-A8788D92-5C7E-4D96-B703-B2B660F2ACD6Q34562315-1EB4E0A9-F74D-4E28-BCDF-D28FD71E46C0Q34724204-A93D17B0-7023-4BA6-8E12-BA4500C1EDFDQ34758271-A635E855-3673-44D8-9D5B-799E5EABA458Q35098365-890315F9-3E01-4803-B820-2F4DC69FE9B8Q35104855-86454269-E07C-4AA3-B075-03B2C1E41919Q35569960-A1107049-9F4C-49B4-B2D0-E5337E582941Q36147666-52888593-C1C5-4F81-B53D-89BD8C20136BQ36667129-51977A31-D016-477A-B4E2-91EA1FCA5CB7Q36672715-8A71A123-67E3-48F6-8FDB-DBFE20560167Q36745310-7F0E26E7-7A39-46CC-A9F4-99208715CD73Q37266199-9207EB3A-72DF-4233-A8FA-0BA4BBCDD74BQ37439161-33F3D1F7-E589-4DAE-A325-A0B00601CAEAQ37488507-4A117EE1-05FC-4EE6-BE29-4C37FBE97905Q37505662-E564108A-673A-4722-816E-3D39D302430CQ37576098-90A704D8-81A2-4DA9-B2A1-EE1EE3BD6F6C
P2860
Metronidazole activation is mutagenic and causes DNA fragmentation in Helicobacter pylori and in Escherichia coli containing a cloned H. pylori RdxA(+) (Nitroreductase) gene.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
@zh
2000年學術文章
@zh-hant
name
Metronidazole activation is mu ...... aining a cloned H. pylori RdxA
@nl
Metronidazole activation is mu ...... RdxA(+) (Nitroreductase) gene.
@en
type
label
Metronidazole activation is mu ...... aining a cloned H. pylori RdxA
@nl
Metronidazole activation is mu ...... RdxA(+) (Nitroreductase) gene.
@en
prefLabel
Metronidazole activation is mu ...... aining a cloned H. pylori RdxA
@nl
Metronidazole activation is mu ...... RdxA(+) (Nitroreductase) gene.
@en
P2093
P2860
P1476
Metronidazole activation is mu ...... RdxA(+) (Nitroreductase) gene.
@en
P2093
A Raudonikiene
P S Hoffman
S Lim-Morrison
P2860
P304
P356
10.1128/JB.182.18.5091-5096.2000
P407
P577
2000-09-01T00:00:00Z