Cross-species binding analyses of mouse and human neonatal Fc receptor show dramatic differences in immunoglobulin G and albumin binding.
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Unraveling the Interaction between FcRn and Albumin: Opportunities for Design of Albumin-Based TherapeuticsWaiving in vivo studies for monoclonal antibody biosimilar development: National and global challengesChallenges and advances in the assessment of the disposition of antibody-drug conjugatesNeonatal Fc receptor and IgG-based therapeuticsThe neonatal Fc receptor, FcRn, as a target for drug delivery and therapySite-specific albumination of a therapeutic protein with multi-subunit to prolong activity in vivoNovel ubiquitin-derived high affinity binding proteins with tumor targeting properties.Projecting human pharmacokinetics of monoclonal antibodies from nonclinical data: comparative evaluation of prediction approaches in early drug development.Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injuryExtending serum half-life of albumin by engineering neonatal Fc receptor (FcRn) binding.High-dose IgG therapy mitigates bile duct-targeted inflammation and obstruction in a mouse model of biliary atresiaUsing 2-photon microscopy to understand albuminuria.Structure-based mutagenesis reveals the albumin-binding site of the neonatal Fc receptor.Neonatal Fc receptor: from immunity to therapeuticsSelection of nanobodies that target human neonatal Fc receptor.Extending half-life by indirect targeting of the neonatal Fc receptor (FcRn) using a minimal albumin binding domain.Robust expression of the human neonatal Fc receptor in a truncated soluble form and as a full-length membrane-bound protein in fusion with eGFPPulmonary microvascular albumin leak is associated with endothelial cell death in murine sepsis-induced lung injury in vivoCharacterization and screening of IgG binding to the neonatal Fc receptor.Polymeric human Fc-fusion proteins with modified effector functions.Genetically engineered humanized mouse models for preclinical antibody studies.CD47 is an adverse prognostic factor and a therapeutic target in gastric cancer.Anti-carcinoembryonic antigen single-chain variable fragment antibody variants bind mouse and human neonatal Fc receptor with different affinities that reveal distinct cross-species differences in serum half-lifeImproving target cell specificity using a novel monovalent bispecific IgG designAlbumin-deficient mouse models for studying metabolism of human albumin and pharmacokinetics of albumin-based drugsChallenges and opportunities in absorption, distribution, metabolism, and excretion studies of therapeutic biologics.Pharmacokinetics of engineered human monomeric and dimeric CH2 domainsA dicarboxylic fatty acid derivative of paclitaxel for albumin-assisted drug delivery.Mechanism of increased clearance of glycated albumin by proximal tubule cells.Improved in vivo anti-tumor effects of IgA-Her2 antibodies through half-life extension and serum exposure enhancement by FcRn targetingCross-species analysis of Fc engineered anti-Lewis-Y human IgG1 variants in human neonatal receptor transgenic mice reveal importance of S254 and Y436 in binding human neonatal Fc receptor.The proximal tubule and albuminuria: really!The placenta, transfer of immunoglobulins, and safety assessment of biopharmaceuticals in pregnancy.Epithelial cell adhesion molecule-targeted drug delivery for cancer therapy.Albumin and its application in drug delivery.Accelerating antibody discovery using transgenic animals overexpressing the neonatal Fc receptor as a result of augmented humoral immunity.Bioanalytical approaches to assess the proteolytic stability of therapeutic fusion proteins.Modulators of IgG penetration through the blood-brain barrier: Implications for Alzheimer's disease immunotherapy.Binding structures and energies of the human neonatal Fc receptor with human Fc and its mutants by molecular modeling and dynamics simulations.Competition for FcRn-mediated transport gives rise to short half-life of human IgG3 and offers therapeutic potential.
P2860
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P2860
Cross-species binding analyses of mouse and human neonatal Fc receptor show dramatic differences in immunoglobulin G and albumin binding.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Cross-species binding analyses ...... lobulin G and albumin binding.
@en
Cross-species binding analyses ...... lobulin G and albumin binding.
@nl
type
label
Cross-species binding analyses ...... lobulin G and albumin binding.
@en
Cross-species binding analyses ...... lobulin G and albumin binding.
@nl
prefLabel
Cross-species binding analyses ...... lobulin G and albumin binding.
@en
Cross-species binding analyses ...... lobulin G and albumin binding.
@nl
P2860
P50
P356
P1476
Cross-species binding analyses ...... lobulin G and albumin binding.
@en
P2093
Gøril Berntzen
Muluneh Bekele Daba
P2860
P304
P356
10.1074/JBC.M109.081828
P407
P577
2009-12-14T00:00:00Z