A mechanistic understanding of production instability in CHO cell lines expressing recombinant monoclonal antibodies.
about
Mechanisms underlying epigenetic and transcriptional heterogeneity in Chinese hamster ovary (CHO) cell linesEngineering Translation in Mammalian Cell Factories to Increase Protein Yield: The Unexpected Use of Long Non-Coding SINEUP RNAsEfficient recombinant production in mammalian cells using a novel IR/MAR gene amplification methodFusion of the Dhfr/Mtx and IR/MAR gene amplification methods produces a rapid and efficient method for stable recombinant protein production.Synthetic promoters for CHO cell engineering.Transcriptome study and identification of potential marker genes related to the stable expression of recombinant proteins in CHO clones.A novel regulatory element (E77) isolated from CHO-K1 genomic DNA enhances stable gene expression in Chinese hamster ovary cellsFISH-Based Analysis of Clonally Derived CHO Cell Populations Reveals High Probability for Transgene Integration in a Terminal Region of Chromosome 1 (1q13).Evaluating the use of a CpG free promoter for long-term recombinant protein expression stability in Chinese hamster ovary cells.Impact of Different Promoters on Episomal Vectors Harbouring Characteristic Motifs of Matrix Attachment Regions.Comprehensive genome and epigenome characterization of CHO cells in response to evolutionary pressures and over time.CHO microRNA engineering is growing up: recent successes and future challenges.Establishment of a CpG island microarray for analyses of genome-wide DNA methylation in Chinese hamster ovary cells.Expression of a Human Prostatic Acid Phosphatase (PAP)-IgM Fc Fusion Protein in Plants Using In vitro Tissue Subculture.Blood Clotting Factor VIII: From Evolution to Therapy.Identifying and engineering promoters for high level and sustainable therapeutic recombinant protein production in cultured mammalian cells.Ubiquitous Chromatin Opening Elements (UCOEs) effect on transgene position and expression stability in CHO cells following methotrexate (MTX) amplification.Epigenetic regulatory elements: Recent advances in understanding their mode of action and use for recombinant protein production in mammalian cells.Genetic analysis of the clonal stability of Chinese hamster ovary cells for recombinant protein production.Cell line development for biomanufacturing processes: recent advances and an outlook.The 'Omics Revolution in CHO Biology: Roadmap to Improved CHO Productivity.Improved CHO Cell Line Stability and Recombinant Protein Expression During Long-Term Culture.Utilization of sequence variants as biomarkers to analyze population dynamics in cloned cell lines.A framework to quantify karyotype variation associated with CHO cell line instability at a single-cell level.Genetic analyses of Per.C6 cell clones producing a therapeutic monoclonal antibody regarding productivity and long-term stability.Fam60A plays a role for production stabilities of recombinant CHO cell lines.Identification of regulatory motifs in the CHO genome for stable monoclonal antibody production.High levels of histone H3 acetylation at the CMV promoter are predictive of stable expression in Chinese hamster ovary cells.Deletion of a telomeric region on chromosome 8 correlates with higher productivity and stability of CHO cell lines.Microarray profiling of preselected CHO host cell subclones identifies gene expression patterns associated with increased production capacity.Effects of passage number on growth and productivity of hybridoma secreting MRSA anti-PBP2a monoclonal antibodies.Assessment of UCOE on Recombinant EPO Production and Expression Stability in Amplified Chinese Hamster Ovary Cells.Evaluating the interaction between UCOE and DHFR-linked amplification and stability of recombinant protein expression.Accurate comparison of antibody expression levels by reproducible transgene targeting in engineered recombination-competent CHO cells.Model-directed engineering of "difficult-to-express" monoclonal antibody production by Chinese hamster ovary cells.Determination of Chinese hamster ovary cell line stability and recombinant antibody expression during long-term culture.Transgene copy number distribution profiles in recombinant CHO cell lines revealed by single cell analyses.CMV promoter mutants with a reduced propensity to productivity loss in CHO cells.Stable expression of H1C2 monoclonal antibody in NS0 and CHO cells using pFUSE and UCOE expression system.Toward stable gene expression in CHO cells.
P2860
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P2860
A mechanistic understanding of production instability in CHO cell lines expressing recombinant monoclonal antibodies.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
A mechanistic understanding of ...... mbinant monoclonal antibodies.
@en
A mechanistic understanding of ...... mbinant monoclonal antibodies.
@nl
type
label
A mechanistic understanding of ...... mbinant monoclonal antibodies.
@en
A mechanistic understanding of ...... mbinant monoclonal antibodies.
@nl
prefLabel
A mechanistic understanding of ...... mbinant monoclonal antibodies.
@en
A mechanistic understanding of ...... mbinant monoclonal antibodies.
@nl
P2093
P2860
P356
P1476
A mechanistic understanding of ...... mbinant monoclonal antibodies.
@en
P2093
David C James
Kurt A Droms
Minsoo Kim
Peter M O'Callaghan
P2860
P304
P356
10.1002/BIT.23189
P577
2011-05-19T00:00:00Z