Primary human immunodeficiency virus type 2 (HIV-2) isolates infect CD4-negative cells via CCR5 and CXCR4: comparison with HIV-1 and simian immunodeficiency virus and relevance to cell tropism in vivo
about
The promiscuous CC chemokine receptor D6 is a functional coreceptor for primary isolates of human immunodeficiency virus type 1 (HIV-1) and HIV-2 on astrocytes.Apoptosis of uninfected cells induced by HIV envelope glycoproteinsHIV-1 envelope-receptor interactions required for macrophage infection and implications for current HIV-1 cure strategiesGeneration of neutralizing antibodies and divergence of SIVmac239 in cynomolgus macaques following short-term early antiretroviral therapyHIV and the chemokine system: 10 years later.Human immunodeficiency virus type 1 efficiently binds to human fetal astrocytes and induces neuroinflammatory responses independent of infectionCurrent concepts regarding the HTLV-1 receptor complex.Restrictions to cross-species transmission of lentiviral infection gleaned from studies of FIVInterferon-alpha mediates restriction of human immunodeficiency virus type-1 replication in primary human macrophages at an early stage of replication.Mechanisms for adaptation of simian immunodeficiency virus to replication in alveolar macrophagesN-linked glycosylation of CXCR4 masks coreceptor function for CCR5-dependent human immunodeficiency virus type 1 isolates.Simian immunodeficiency viruses of diverse origin can use CXCR4 as a coreceptor for entry into human cellsCD4-independent use of Rhesus CCR5 by human immunodeficiency virus Type 2 implicates an electrostatic interaction between the CCR5 N terminus and the gp120 C4 domain.Relationships between CD4 independence, neutralization sensitivity, and exposure of a CD4-induced epitope in a human immunodeficiency virus type 1 envelope protein.CKR-L3, a deletion version CCR6-isoform shows coreceptor-activity for limited human and simian immunodeficiency viruses.Contribution of intrinsic reactivity of the HIV-1 envelope glycoproteins to CD4-independent infection and global inhibitor sensitivity.Regulation of human immunodeficiency virus type 1 envelope glycoprotein fusion by a membrane-interactive domain in the gp41 cytoplasmic tail.Receptors and entry cofactors for retroviruses include single and multiple transmembrane-spanning proteins as well as newly described glycophosphatidylinositol-anchored and secreted proteins.Potent and broadly reactive HIV-2 neutralizing antibodies elicited by a vaccinia virus vector prime-C2V3C3 polypeptide boost immunization strategy.Rapid progression to simian AIDS can be accompanied by selection of CD4-independent gp120 variants with impaired ability to bind CD4.Identification of gp120 binding sites on CXCR4 by using CD4-independent human immunodeficiency virus type 2 Env proteins.HIV-2 interaction with cell coreceptors: amino acids within the V1/V2 region of viral envelope are determinant for CCR8, CCR5 and CXCR4 usage.Identification of a subset of human immunodeficiency virus type 1 (HIV-1), HIV-2, and simian immunodeficiency virus strains able to exploit an alternative coreceptor on untransformed human brain and lymphoid cells.Human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 use different receptor complexes to enter T cells.Isolation of CD4-independent primary human immunodeficiency virus type 1 isolates that are syncytium inducing and acutely cytopathic for CD8+ lymphocytes.Human immunodeficiency virus infection of the brain: pitfalls in evaluating infected/affected cell populations.Susceptibility of HIV type 2 primary isolates to CCR5 and CXCR4 monoclonal antibodies, ligands, and small molecule inhibitorsCharacterization and Implementation of a Diverse Simian Immunodeficiency Virus SIVsm Envelope Panel in the Assessment of Neutralizing Antibody Breadth Elicited in Rhesus Macaques by Multimodal Vaccines Expressing the SIVmac239 Envelope.CD4-independent use of the CCR5 receptor by sequential primary SIVsm isolatesChanges in the V3 region of gp120 contribute to unusually broad coreceptor usage of an HIV-1 isolate from a CCR5 Delta32 heterozygote.Lineage-specific differences between human and simian immunodeficiency virus regulation of gp120 trimer association and CD4 bindingAccurate predictions of population-level changes in sequence and structural properties of HIV-1 Env using a volatility-controlled diffusion model.Derivation and Characterization of a CD4-Independent, Non-CD4-Tropic Simian Immunodeficiency Virus.HIV-1-infected astrocytes and the microglial proteome.Linkages between HIV-1 specificity for CCR5 or CXCR4 and in vitro usage of alternative coreceptors during progressive HIV-1 subtype C infection.A genotypic method for determining HIV-2 coreceptor usage enables epidemiological studies and clinical decision support.CXCR4-dependent infection of CD8+, but not CD4+, lymphocytes by a primary human immunodeficiency virus type 1 isolate.Conformational HIV-1 envelope on particulate structures: a tool for chemokine coreceptor binding studies.HIV-1 endocytosis in astrocytes: a kiss of death or survival of the fittest?Lineage-Specific Differences between the gp120 Inner Domain Layer 3 of Human Immunodeficiency Virus and That of Simian Immunodeficiency Virus
P2860
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P2860
Primary human immunodeficiency virus type 2 (HIV-2) isolates infect CD4-negative cells via CCR5 and CXCR4: comparison with HIV-1 and simian immunodeficiency virus and relevance to cell tropism in vivo
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Primary human immunodeficiency ...... evance to cell tropism in vivo
@en
Primary human immunodeficiency virus type 2
@nl
type
label
Primary human immunodeficiency ...... evance to cell tropism in vivo
@en
Primary human immunodeficiency virus type 2
@nl
prefLabel
Primary human immunodeficiency ...... evance to cell tropism in vivo
@en
Primary human immunodeficiency virus type 2
@nl
P2093
P2860
P1433
P1476
Primary human immunodeficiency ...... evance to cell tropism in vivo
@en
P2093
A McKnight
J D Reeves
J M Azevedo-Pereira
J Moniz-Pereira
P R Clapham
S Hibbitts
P2860
P304
P407
P577
1999-09-01T00:00:00Z