An anti-Aβ (amyloid β) single-chain variable fragment prevents amyloid fibril formation and cytotoxicity by withdrawing Aβ oligomers from the amyloid pathway.
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Disease modifying therapies for Alzheimer's disease targeting Aβ oligomers: implications for therapeutic mechanismsAssessment of the effect of triton X-114 on the physicochemical properties of an antibody fragment.Loss of deep cerebellar nuclei neurons in the 3xTg-AD mice and protection by an anti-amyloid β antibody fragment.Early intervention in the 3xTg-AD mice with an amyloid β-antibody fragment ameliorates first hallmarks of Alzheimer disease.Production of an anti-Aβ antibody fragment in Pichia pastoris and in vitro and in vivo validation of its therapeutic effect.MLK3-MKK3/6-P38MAPK cascades following N-methyl-D-aspartate receptor activation contributes to amyloid-β peptide-induced apoptosis in SH-SY5Y cells.Mutations can cause light chains to be too stable or too unstable to form amyloid fibrils.Elongation of the C-terminal domain of an anti-amyloid β single-chain variable fragment increases its thermodynamic stability and decreases its aggregation tendency.Effects of an Aβ-antibody fragment on Aβ aggregation and astrocytic uptake are modulated by apolipoprotein E and J mimetic peptides.An Intracellular Amyloid-β/AβPP Epitope Correlates with Neurodegeneration in those Neuronal Populations Early Involved in Alzheimer's Disease.Towards the improvement in stability of an anti-Aβ single-chain variable fragment, scFv-h3D6, as a way to enhance its therapeutic potential.Understanding the contribution of disulfide bridges to the folding and misfolding of an anti-Aβ scFv.A hypothetical hierarchical mechanism of the self-assembly of the Escherichia coli RNA polymerase σ(70) subunit.
P2860
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P2860
An anti-Aβ (amyloid β) single-chain variable fragment prevents amyloid fibril formation and cytotoxicity by withdrawing Aβ oligomers from the amyloid pathway.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
An anti-Aβ (amyloid β) single- ...... mers from the amyloid pathway.
@en
An anti-Aβ
@nl
type
label
An anti-Aβ (amyloid β) single- ...... mers from the amyloid pathway.
@en
An anti-Aβ
@nl
prefLabel
An anti-Aβ (amyloid β) single- ...... mers from the amyloid pathway.
@en
An anti-Aβ
@nl
P2093
P2860
P356
P1433
P1476
An anti-Aβ (amyloid β) single- ...... mers from the amyloid pathway.
@en
P2093
Geovanny Rivera-Hernández
Joaquim Martí
Marta Marín-Argany
P2860
P356
10.1042/BJ20101712
P407
P577
2011-07-01T00:00:00Z