Pancreatic β cell identity is maintained by DNA methylation-mediated repression of Arx. - Wikidata - awgldk - TriplyDB

Pancreatic β cell identity is maintained by DNA methylation-mediated repression of Arx.

Pancreatic β cell identity is maintained by DNA methylation-mediated repression of Arx.

http://www.wikidata.org/entity/Q39557781

about

Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors β-Cell regeneration through the transdifferentiation of pancreatic cells: Pancreatic progenitor cells in the pancreas Insulin-secreting β cells require a post-genomic concept Epigenetics: the missing link to understanding β-cell dysfunction in the pathogenesis of type 2 diabetes Translational implications of the β-cell epigenome in diabetes mellitus Toying with fate: Redirecting the differentiation of adrenocortical progenitor cells into gonadal-like tissue Control of cell identity in pancreas development and regeneration Maintenance of β-cell maturity and plasticity in the adult pancreas: developmental biology concepts in adult physiology Epigenetic Regulation of Islet Development and Regeneration DNA methylation restricts lineage-specific functions of transcription factor Gata4 during embryonic stem cell differentiation Adult tissue sources for new β cells.Bmi1 Is a Key Epigenetic Barrier to Direct Cardiac Reprogramming.Increased DNA methylation and decreased expression of PDX-1 in pancreatic islets from patients with type 2 diabetes.Gene-Diet Interactions in Type 2 Diabetes: The Chicken and Egg Debate Integration of signals along orthogonal axes of the vertebrate neural tube controls progenitor competence and increases cell diversity Adult cell plasticity in vivo: de-differentiation and transdifferentiation are back in style.Reversible changes in pancreatic islet structure and function produced by elevated blood glucose.Revealing transcription factors during human pancreatic β cell development.A novel dual-color reporter for identifying insulin-producing beta-cells and classifying heterogeneity of insulinoma cell lines Islet-1 Is essential for pancreatic β-cell function.Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity.Pancreatic and Islet Development and Function: The Role of Thyroid Hormone.Laser capture microdissection-reduced representation bisulfite sequencing (LCM-RRBS) maps changes in DNA methylation associated with gonadectomy-induced adrenocortical neoplasia in the mouse.Novel markers of gonadectomy-induced adrenocortical neoplasia in the mouse and ferret Transdifferentiation of pancreatic α-cells into insulin-secreting cells: From experimental models to underlying mechanisms.A systems view of epigenetic networks regulating pancreas development and β-cell function Gluco-incretins regulate beta-cell glucose competence by epigenetic silencing of Fxyd3 expression β-Cell Generation: Can Rodent Studies Be Translated to Humans?Elevated Hedgehog/Gli signaling causes beta-cell dedifferentiation in mice.An integrated cell purification and genomics strategy reveals multiple regulators of pancreas development.Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming.Stem cell approaches for diabetes: towards beta cell replacement.Transient expression of Ngn3 in Xenopus endoderm promotes early and ectopic development of pancreatic beta and delta cells.β-Cell-Specific Mafk Overexpression Impairs Pancreatic Endocrine Cell Development.Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets.Deconstructing pancreas developmental biology.Treatment with the cancer drugs decitabine and doxorubicin induces human skin keratinocytes to express Oct4 and the OCT4 regulator mir-145.Generation of Functional Beta-Like Cells from Human Exocrine Pancreas.DNA methylation directs functional maturation of pancreatic β cells.

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P2860

Pancreatic β cell identity is maintained by DNA methylation-mediated repression of Arx.

http://www.wikidata.org/entity/Q39557781

description

2011 nî lūn-bûn

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

2011年论文

@zh

2011年论文

@zh-cn

name

Pancreatic β cell identity is maintained by DNA methylation-mediated repression of Arx.

@en

Pancreatic β cell identity is maintained by DNA methylation-mediated repression of Arx.

@nl

type

label

Pancreatic β cell identity is maintained by DNA methylation-mediated repression of Arx.

@en

Pancreatic β cell identity is maintained by DNA methylation-mediated repression of Arx.

@nl

prefLabel

Pancreatic β cell identity is maintained by DNA methylation-mediated repression of Arx.

@en

Pancreatic β cell identity is maintained by DNA methylation-mediated repression of Arx.

@nl

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P356

J.DEVCEL.2011.03.012

P1433

Developmental Cell

P1476

Pancreatic β cell identity is maintained by DNA methylation-mediated repression of Arx.

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P2093

Anil Bhushan

http://www.w3.org/2001/XMLSchema#string

Sangeeta Dhawan

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Senta Georgia

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Shuen-Ing Tschen

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P2860

DNA methylation patterns and epigenetic memory

EUKARYOTIC CYTOSINE METHYLTRANSFERASES

Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive

PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

Direct conversion of fibroblasts to functional neurons by defined factors

The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells

Direct cell reprogramming is a stochastic process amenable to acceleration

Generalized lacZ expression with the ROSA26 Cre reporter strain

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

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419-429

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10.1016/J.DEVCEL.2011.03.012

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21497756

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DNA methylation

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3086024

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