Definition of the role of tyrosine residues of the common beta subunit regulating multiple signaling pathways of granulocyte-macrophage colony-stimulating factor receptor
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Growth factor pleiotropy is controlled by a receptor Tyr/Ser motif that acts as a binary switchNew role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathwayCREB in the pathophysiology of cancer: implications for targeting transcription factors for cancer therapyThe role of interchain heterodisulfide formation in activation of the human common beta and mouse betaIL-3 receptors.Structural and functional hot spots in cytokine receptors.Cooperation of cytokine signaling with chimeric transcription factors in leukemogenesis: PML-retinoic acid receptor alpha blocks growth factor-mediated differentiation.JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis.Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor.Genetic disruption of the PI3K regulatory subunits, p85α, p55α, and p50α, normalizes mutant PTPN11-induced hypersensitivity to GM-CSF.The Shc-binding site of the betac subunit of the GM-CSF/IL-3/IL-5 receptors is a negative regulator of hematopoiesisInherited predispositions and hyperactive Ras in myeloid leukemogenesis.Signal transduction activator of transcription 5 (STAT5) dysfunction in autoimmune monocytes and macrophagesCrossing paths: interactions between the cell death machinery and growth factor survival signals.The GM-CSF receptor family: mechanism of activation and implications for disease.Activation and functional analysis of Janus kinase 2 in BA/F3 cells using the coumermycin/gyrase B system.Two distinct signaling pathways downstream of Janus kinase 2 play redundant roles for antiapoptotic activity of granulocyte-macrophage colony-stimulating factor.CBL linker region and RING finger mutations lead to enhanced granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling via elevated levels of JAK2 and LYN.A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GM-CSF.Cytokine receptor common beta subunit-mediated STAT5 activation confers NF-kappa B activation in murine proB cell line Ba/F3 cells.Cell cycle-dependent interaction of Mad2 with conserved Box1/2 region of human granulocyte-macrophage colony-stimulating factor receptor common betac.Cooperation between STAT5 and phosphatidylinositol 3-kinase in the IL-3-dependent survival of a bone marrow derived cell line.Analysis of mechanisms involved in the prevention of gamma irradiation-induced apoptosis by hGM-CSF.Association of Lyn tyrosine kinase to the GM-CSF and IL-3 receptor common betac subunit and role of Src tyrosine kinases in DNA synthesis and anti-apoptosis.The role of disulfide-linked dimerization in interleukin-3 receptor signaling and biological activity.Regulation and function of protein kinase B and MAP kinase activation by the IL-5/GM-CSF/IL-3 receptor.Constitutive activation of JAK2 confers murine interleukin-3-independent survival and proliferation of BA/F3 cells.Mechanism of activation of the GM-CSF, IL-3, and IL-5 family of receptors.In vitro analysis of STAT5 activation by granulocyte-macrophage colony-stimulating factor.Multiple Signals Mediate Proliferation, Differentiation, and Survival from the Granulocyte Colony-stimulating Factor Receptor in Myeloid 32D Cells
P2860
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P2860
Definition of the role of tyrosine residues of the common beta subunit regulating multiple signaling pathways of granulocyte-macrophage colony-stimulating factor receptor
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Definition of the role of tyro ...... ny-stimulating factor receptor
@en
Definition of the role of tyro ...... y-stimulating factor receptor.
@nl
type
label
Definition of the role of tyro ...... ny-stimulating factor receptor
@en
Definition of the role of tyro ...... y-stimulating factor receptor.
@nl
prefLabel
Definition of the role of tyro ...... ny-stimulating factor receptor
@en
Definition of the role of tyro ...... y-stimulating factor receptor.
@nl
P2093
P2860
P356
P1476
Definition of the role of tyro ...... ny-stimulating factor receptor
@en
P2093
P2860
P304
P356
10.1128/MCB.18.2.742
P407
P577
1998-02-01T00:00:00Z