Adenovirus type 5 E4 open reading frame 4 protein induces apoptosis in transformed cells.
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Leucine carboxyl methyltransferase-1 is necessary for normal progression through mitosis in mammalian cellsAvian Reoviruses Cause Apoptosis in Cultured Cells: Viral Uncoating, but Not Viral Gene Expression, Is Required for Apoptosis InductionMechanisms of cancer cell killing by the adenovirus E4orf4 proteinThe Human Adenovirus Type 5 E4orf4 Protein Targets Two Phosphatase Regulators of the Hippo Signaling PathwayThe Adenovirus E4orf4 Protein Provides a Novel Mechanism for Inhibition of the DNA Damage ResponseStructure- and modeling-based identification of the adenovirus E4orf4 binding site in the protein phosphatase 2A B55α subunitAdenovirus E4orf4 protein induces PP2A-dependent growth arrest in Saccharomyces cerevisiae and interacts with the anaphase-promoting complex/cyclosome.Adenovirus E4 open reading frame 4-induced apoptosis involves dysregulation of Src family kinases.Cytoplasmic death signal triggered by SRC-mediated phosphorylation of the adenovirus E4orf4 protein.Adenovirus E4orf4 hijacks rho GTPase-dependent actin dynamics to kill cells: a role for endosome-associated actin assembly.Localization and importance of the adenovirus E4orf4 protein during lytic infectionAnalysis by live imaging of effects of the adenovirus E4orf4 protein on passage through mitosis of H1299 tumor cells.The adenovirus E4-ORF4 splicing enhancer protein interacts with a subset of phosphorylated SR proteins.The cytosolic tail of the Golgi apyrase Ynd1 mediates E4orf4-induced toxicity in Saccharomyces cerevisiae.The early region 4 orf4 protein of human adenovirus type 5 induces p53-independent cell death by apoptosis.Recombinant, replication-defective adenovirus gene transfer vectors induce cell cycle dysregulation and inappropriate expression of cyclin proteins.Efficient gene transfer into human CD34(+) cells by a retargeted adenovirus vectorInduction of p53-independent apoptosis by the adenovirus E4orf4 protein requires binding to the Balpha subunit of protein phosphatase 2A.Regulation of adenovirus-mediated transgene expression by the viral E4 gene products: requirement for E4 ORF3.Induction of transformation and p53-dependent apoptosis by adenovirus type 5 E4orf6/7 cDNA.Several E4 region functions influence mammary tumorigenesis by human adenovirus type 9A high-capacity, capsid-modified hybrid adenovirus/adeno-associated virus vector for stable transduction of human hematopoietic cellsGenetic analysis of B55alpha/Cdc55 protein phosphatase 2A subunits: association with the adenovirus E4orf4 protein.Interaction of adenovirus type 5 E4orf4 with the nuclear pore subunit Nup205 is required for proper viral gene expression.Adenovirus replaces mitotic checkpoint controls.Induction of apoptosis by adenovirus E4orf4 protein is specific to transformed cells and requires an interaction with protein phosphatase 2A.Cdc55p-mediated E4orf4 growth inhibition in Saccharomyces cerevisiae is mediated only in part via the catalytic subunit of protein phosphatase 2A.E4orf4 induces PP2A- and Src-dependent cell death in Drosophila melanogaster and at the same time inhibits classic apoptosis pathways.The adenovirus E4orf4 protein induces G2/M arrest and cell death by blocking protein phosphatase 2A activity regulated by the B55 subunit.A functional interplay between the small GTPase Rab11a and mitochondria-shaping proteins regulates mitochondrial positioning and polarization of the actin cytoskeleton downstream of Src family kinases.Inhibition of NF-kappaB activation in combination with bcl-2 expression allows for persistence of first-generation adenovirus vectors in the mouse liverStrategic attack on host cell gene expression during adenovirus infection.Identification of the adenovirus E4orf4 protein binding site on the B55α and Cdc55 regulatory subunits of PP2A: Implications for PP2A function, tumor cell killing and viral replication.Adenovirus E4orf4 protein-induced death of p53-/- H1299 human cancer cells follows a G1 arrest of both tetraploid and diploid cells due to a failure to initiate DNA synthesis.Preparation of cell-lines for conditional knockdown of gene expression and measurement of the knockdown effects on E4orf4-induced cell deathTwo distinct activities contribute to the oncogenic potential of the adenovirus type 5 E4orf6 protein.Caspase activation by adenovirus e4orf4 protein is cell line specific and Is mediated by the death receptor pathway."Hit-and-run" transformation by adenovirus oncogenesSelection of apoptosis-deficient adenovirus E4orf4 mutants in Saccharomyces cerevisiaeInduction of p53-independent apoptosis by simian virus 40 small t antigen.
P2860
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P2860
Adenovirus type 5 E4 open reading frame 4 protein induces apoptosis in transformed cells.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Adenovirus type 5 E4 open reading frame 4 protein induces apoptosis in transformed cells.
@en
Adenovirus type 5 E4 open reading frame 4 protein induces apoptosis in transformed cells.
@nl
type
label
Adenovirus type 5 E4 open reading frame 4 protein induces apoptosis in transformed cells.
@en
Adenovirus type 5 E4 open reading frame 4 protein induces apoptosis in transformed cells.
@nl
prefLabel
Adenovirus type 5 E4 open reading frame 4 protein induces apoptosis in transformed cells.
@en
Adenovirus type 5 E4 open reading frame 4 protein induces apoptosis in transformed cells.
@nl
P2860
P1433
P1476
Adenovirus type 5 E4 open reading frame 4 protein induces apoptosis in transformed cells
@en
P2093
Kleinberger T
Shtrichman R
P2860
P304
P407
P577
1998-04-01T00:00:00Z