Induction of p53-independent apoptosis by the adenovirus E4orf4 protein requires binding to the Balpha subunit of protein phosphatase 2A.
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Leucine carboxyl methyltransferase-1 is necessary for normal progression through mitosis in mammalian cellsProtein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signallingMechanisms of cancer cell killing by the adenovirus E4orf4 proteinAlterations in protein phosphatase 2A subunit interaction in human carcinomas of the lung and colon with mutations in the A beta subunit geneThe Human Adenovirus Type 5 E4orf4 Protein Targets Two Phosphatase Regulators of the Hippo Signaling PathwayThe Adenovirus E4orf4 Protein Provides a Novel Mechanism for Inhibition of the DNA Damage ResponseStructure- and modeling-based identification of the adenovirus E4orf4 binding site in the protein phosphatase 2A B55α subunitAdenovirus E4 open reading frame 4-induced apoptosis involves dysregulation of Src family kinases.Cytoplasmic death signal triggered by SRC-mediated phosphorylation of the adenovirus E4orf4 protein.Adenovirus E4orf4 hijacks rho GTPase-dependent actin dynamics to kill cells: a role for endosome-associated actin assembly.Localization and importance of the adenovirus E4orf4 protein during lytic infectionAnalysis by live imaging of effects of the adenovirus E4orf4 protein on passage through mitosis of H1299 tumor cells.The adenovirus E4-ORF4 splicing enhancer protein interacts with a subset of phosphorylated SR proteins.The cytosolic tail of the Golgi apyrase Ynd1 mediates E4orf4-induced toxicity in Saccharomyces cerevisiae.Actions of PP2A on the MAP kinase pathway and apoptosis are mediated by distinct regulatory subunits.Genetic analysis of B55alpha/Cdc55 protein phosphatase 2A subunits: association with the adenovirus E4orf4 protein.The role of adenovirus E4orf4 protein in viral replication and cell killing.Interaction of adenovirus type 5 E4orf4 with the nuclear pore subunit Nup205 is required for proper viral gene expression.Inactivating intracellular antiviral responses during adenovirus infection.Distinct cell death pathways triggered by the adenovirus early region 4 ORF 4 protein.Cdc55p-mediated E4orf4 growth inhibition in Saccharomyces cerevisiae is mediated only in part via the catalytic subunit of protein phosphatase 2A.PP2A Counterbalances Phosphorylation of pRB and Mitotic Proteins by Multiple CDKs: Potential Implications for PP2A Disruption in CancerE4orf4 induces PP2A- and Src-dependent cell death in Drosophila melanogaster and at the same time inhibits classic apoptosis pathways.The adenovirus E4orf4 protein induces G2/M arrest and cell death by blocking protein phosphatase 2A activity regulated by the B55 subunit.A functional interplay between the small GTPase Rab11a and mitochondria-shaping proteins regulates mitochondrial positioning and polarization of the actin cytoskeleton downstream of Src family kinases.Identification of the adenovirus E4orf4 protein binding site on the B55α and Cdc55 regulatory subunits of PP2A: Implications for PP2A function, tumor cell killing and viral replication.Adenovirus E4orf4 protein-induced death of p53-/- H1299 human cancer cells follows a G1 arrest of both tetraploid and diploid cells due to a failure to initiate DNA synthesis.Selection of apoptosis-deficient adenovirus E4orf4 mutants in Saccharomyces cerevisiaeInduction of p53-independent apoptosis by simian virus 40 small t antigen.JNK-mediated phosphorylation of paxillin in adhesion assembly and tension-induced cell death by the adenovirus death factor E4orf4.Adenovirus E4orf4 protein downregulates MYC expression through interaction with the PP2A-B55 subunit.Adenovirus protein E4orf4 induces premature APCCdc20 activation in Saccharomyces cerevisiae by a protein phosphatase 2A-dependent mechanismYND1 interacts with CDC55 and is a novel mediator of E4orf4-induced toxicity.Adenoviral proteins mimic nutrient/growth signals to activate the mTOR pathway for viral replication.Nuclear localization of the adenovirus E4orf4 protein is mediated through an arginine-rich motif and correlates with cell death.Induction of p53-independent apoptosis by the BH3-only protein ITM2Bs.Toxicity of human adenovirus E4orf4 protein in Saccharomyces cerevisiae results from interactions with the Cdc55 regulatory B subunit of PP2A.Characterization of the recombinant adenovirus vector AdYB-1: implications for oncolytic vector development.NTPDASE4 gene products cooperate with the adenovirus E4orf4 protein through PP2A-dependent and -independent mechanisms and contribute to induction of cell deathThe adenovirus E4orf4 protein targets PP2A to the ACF chromatin-remodeling factor and induces cell death through regulation of SNF2h-containing complexes.
P2860
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P2860
Induction of p53-independent apoptosis by the adenovirus E4orf4 protein requires binding to the Balpha subunit of protein phosphatase 2A.
description
2000 nî lūn-bûn
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2000 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի սեպտեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
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2000年论文
@wuu
name
Induction of p53-independent a ...... nit of protein phosphatase 2A.
@ast
Induction of p53-independent a ...... nit of protein phosphatase 2A.
@en
type
label
Induction of p53-independent a ...... nit of protein phosphatase 2A.
@ast
Induction of p53-independent a ...... nit of protein phosphatase 2A.
@en
prefLabel
Induction of p53-independent a ...... nit of protein phosphatase 2A.
@ast
Induction of p53-independent a ...... nit of protein phosphatase 2A.
@en
P2093
P2860
P1433
P1476
Induction of p53-independent a ...... nit of protein phosphatase 2A.
@en
P2093
D Paquette
P E Branton
R C Marcellus
S Thirlwell
P2860
P304
P356
10.1128/JVI.74.17.7869-7877.2000
P577
2000-09-01T00:00:00Z