Inhibition of hyaluronan synthesis in breast cancer cells by 4-methylumbelliferone suppresses tumorigenicity in vitro and metastatic lesions of bone in vivo.
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The Importance of CD44 as a Stem Cell Biomarker and Therapeutic Target in CancerRole of hyaluronan in pancreatic cancer biology and therapy: Once again in the spotlightHyaluronan, Inflammation, and Breast Cancer ProgressionModeling vitamin D actions in triple negative/basal-like breast cancer.High-resolution microrheology in the pericellular matrix of prostate cancer cells.Antitumor activity of sulfated hyaluronic acid fragments in pre-clinical models of bladder cancer.4-Methylumbelliferone inhibits ovarian cancer growth by suppressing thymidine phosphorylase expressionOverexpression of CD44 accompanies acquired tamoxifen resistance in MCF7 cells and augments their sensitivity to the stromal factors, heregulin and hyaluronan.4-methylumbelliferone treatment and hyaluronan inhibition as a therapeutic strategy in inflammation, autoimmunity, and cancer.Adhesion glycoprotein CD44 functions as an upstream regulator of a network connecting ERK, AKT and Hippo-YAP pathways in cancer progressionInhibition of Hyaluronic Acid Synthesis Suppresses Angiogenesis in Developing Endometriotic Lesions.Dietary supplement 4-methylumbelliferone: an effective chemopreventive and therapeutic agent for prostate cancer.Inhibition of hyaluronan synthesis restores immune tolerance during autoimmune insulitisBinding of trastuzumab to ErbB2 is inhibited by a high pericellular density of hyaluronan.The hyaluronan synthesis inhibitor 4-methylumbelliferone exhibits antitumor effects against mesenchymal-like canine mammary tumor cells.Synthesis of N-acetyl Glucosamine Analogs as Inhibitors for Hyaluronan Biosynthesis.4-Methylumbelliferone Diminishes Catabolically Activated Articular Chondrocytes and Cartilage Explants via a Mechanism Independent of Hyaluronan Inhibition.Anti-tumor and anti-invasion effects of a combination of 4-methylumbelliferone and ionizing radiation in human fibrosarcoma cells.Activation of the FGFR-STAT3 pathway in breast cancer cells induces a hyaluronan-rich microenvironment that licenses tumor formation.4-Methylumbelliferone Suppresses Hyaluronan Synthesis and Tumor Progression in SCID Mice Intra-abdominally Inoculated With Pancreatic Cancer Cells.A novel ZEB1/HAS2 positive feedback loop promotes EMT in breast cancerThe Development of a Novel Therapeutic Strategy to Target Hyaluronan in the Extracellular Matrix of Pancreatic Ductal Adenocarcinoma.Therapeutic targeting of hyaluronan in the tumor stroma.Targeting hyaluronic acid family for cancer chemoprevention and therapy.Sugars in the microenvironment: the sticky problem of HA turnover in tumors.Relation between hyaluronan synthesis and cell morphology in ovarian clear cell carcinomas.The glycocalyx and its significance in human medicine.Antitumor effects of 4-methylumbelliferone, a hyaluronan synthesis inhibitor, on malignant peripheral nerve sheath tumor.4-methylumbelliferone and imatinib combination enhances senescence induction in chronic myeloid leukemia cell lines.Synergistic effect of targeting the epidermal growth factor receptor and hyaluronan synthesis in oesophageal squamous cell carcinoma cells.The 2016 John J. Abel Award Lecture: Targeting the Mechanical Microenvironment in Cancer.Hyaluronan Does Not Regulate Human Epidermal Keratinocyte Proliferation and DifferentiationHyaluronan stimulates pancreatic cancer cell motility.Hematopoiesis toxicity induced by 4-methylumbelliferon determined in an invertebrate model organism.Akt Signaling Is Sustained by a CD44 Splice Isoform-Mediated Positive Feedback Loop.Desmoplasia in pancreatic cancer. Can we fight it?Antioxidative properties of 4-methylumbelliferone are related to antibacterial activity in the silkworm (Bombyx mori) digestive tract.Accumulation of extracellular hyaluronan by hyaluronan synthase 3 promotes tumor growth and modulates the pancreatic cancer microenvironment.Treatment with the hyaluronic acid synthesis inhibitor 4-methylumbelliferone suppresses SEB-induced lung inflammation.Hyaluronan synthases (HAS1-3) in stromal and malignant cells correlate with breast cancer grade and predict patient survival.
P2860
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P2860
Inhibition of hyaluronan synthesis in breast cancer cells by 4-methylumbelliferone suppresses tumorigenicity in vitro and metastatic lesions of bone in vivo.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Inhibition of hyaluronan synth ...... tatic lesions of bone in vivo.
@en
Inhibition of hyaluronan synth ...... tatic lesions of bone in vivo.
@nl
type
label
Inhibition of hyaluronan synth ...... tatic lesions of bone in vivo.
@en
Inhibition of hyaluronan synth ...... tatic lesions of bone in vivo.
@nl
prefLabel
Inhibition of hyaluronan synth ...... tatic lesions of bone in vivo.
@en
Inhibition of hyaluronan synth ...... tatic lesions of bone in vivo.
@nl
P2093
P2860
P356
P1476
Inhibition of hyaluronan synth ...... tatic lesions of bone in vivo.
@en
P2093
Eiji Kozawa
Eisuke Arai
Hiroshi Urakawa
Junji Wasa
Koji Kimata
Lisheng Zhuo
Naohisa Futamura
Naoki Ishiguro
Yoshihiro Nishida
P2860
P304
P356
10.1002/IJC.26014
P577
2011-04-25T00:00:00Z