Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7. - Wikidata - awgldk - TriplyDB

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7.

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7.

http://www.wikidata.org/entity/Q39582682

about

The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability FBXW7-mediated degradation of CCDC6 is impaired by ATM during DNA damage response in lung cancer cells PI3K-dependent phosphorylation of Fbw7 modulates substrate degradation and activity Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1 Mitochondria, cholesterol and cancer cell metabolism Tumor suppressor genes and their underlying interactions in paclitaxel resistance in cancer therapy Targeting the Mitotic Catastrophe Signaling Pathway in Cancer Regulation of Bim in Health and Disease Targeting the ubiquitin pathway for cancer treatment The BCL2 Family: Key Mediators of the Apoptotic Response to Targeted Anticancer Therapeutics Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases Rational Design of Proteolytically Stable, Cell-Permeable Peptide-Based Selective Mcl-1 Inhibitors Selective Aurora Kinase Inhibitors Identified Using a Taxol-Induced Checkpoint Sensitivity Screen Discovery of Potent Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods and Structure-Based Design A1/Bfl-1 in leukocyte development and cell death Discovery of tricyclic indoles that potently inhibit Mcl-1 using fragment-based methods and structure-based design Discovery of 2-Indole-acylsulfonamide Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods Prediction of response to anti-EGFR antibody-based therapies by multigene sequencing in colorectal cancer patients.Mitochondrial apoptosis and BH3 mimetics Dysregulation of ubiquitin ligases in cancer Exploitation of the Apoptosis-Primed State of MYCN-Amplified Neuroblastoma to Develop a Potent and Specific Targeted Therapy Combination Thr 163 phosphorylation causes Mcl-1 stabilization when degradation is independent of the adjacent GSK3-targeted phosphodegron, promoting drug resistance in cancer Wogonin has multiple anti-cancer effects by regulating c-Myc/SKP2/Fbw7α and HDAC1/HDAC2 pathways and inducing apoptosis in human lung adenocarcinoma cell line A549 Multi-agent chemotherapy overcomes glucocorticoid resistance conferred by a BIM deletion polymorphism in pediatric acute lymphoblastic leukemia A Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1 Characterizing ubiquitination sites by peptide-based immunoaffinity enrichment.Spindle poisons and cell fate: a tale of two pathways.DEPDC1/LET-99 participates in an evolutionarily conserved pathway for anti-tubulin drug-induced apoptosis.Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction Modulating cell-to-cell variability and sensitivity to death ligands by co-drugging.Tumour cell survival mechanisms in lethal metastatic prostate cancer differ between bone and soft tissue metastases.The NOXA-MCL1-BIM axis defines lifespan on extended mitotic arrest USP9X regulates centrosome duplication and promotes breast carcinogenesis.A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL).Synthesis and Biological Evaluation of 2-Methyl-4,5-Disubstituted Oxazoles as a Novel Class of Highly Potent Antitubulin Agents.FBXW7 expression is associated with prognosis and chemotherapeutic outcome in Chinese patients with gastric adenocarcinoma Aberrant regulation of FBW7 in cancer.Pretubulysin: a new option for the treatment of metastatic cancer.An oral quinoline derivative, MPT0B392, causes leukemic cells mitotic arrest and overcomes drug resistant cancer cells Rational combination of dual PI3K/mTOR blockade and Bcl-2/-xL inhibition in AML.

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P2860

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7.

http://www.wikidata.org/entity/Q39582682

description

2011 nî lūn-bûn

@nan

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

2011年论文

@zh

2011年论文

@zh-cn

name

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7.

@en

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7.

@nl

type

label

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7.

@en

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7.

@nl

prefLabel

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7.

@en

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7.

@nl

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P1476

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7.

@en

P2093

Adam R Johnson

http://www.w3.org/2001/XMLSchema#string

Cynthia Lam

http://www.w3.org/2001/XMLSchema#string

David C S Huang

http://www.w3.org/2001/XMLSchema#string

Erin C Dueber

http://www.w3.org/2001/XMLSchema#string

Heather Maecker

http://www.w3.org/2001/XMLSchema#string

Ingrid E Wertz

http://www.w3.org/2001/XMLSchema#string

James A Ernst

http://www.w3.org/2001/XMLSchema#string

Jennie R Lill

http://www.w3.org/2001/XMLSchema#string

Josh S Kaminker

http://www.w3.org/2001/XMLSchema#string

Kanan Pujara

http://www.w3.org/2001/XMLSchema#string

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110-114

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scholarly article

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10.1038/NATURE09779

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7336

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471

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Daniel J. Anderson

Elizabeth Helgason

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2011-03-01T00:00:00Z

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50267720

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1050839842

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21368834

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