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Engineering antibody therapeuticsEfficient Generation of Bispecific Murine Antibodies for Pre-Clinical Investigations in Syngeneic Rodent Models1H NMR investigation of distal mutant deoxy myoglobins. Interpretation of proximal His contact shifts in terms of a localized distal water molecule.Cross-arm binding efficiency of an EGFR x c-Met bispecific antibody.Fc-mediated activity of EGFR x c-Met bispecific antibody JNJ-61186372 enhanced killing of lung cancer cellsIntroduction to membrane proteins.Novel Monoclonal Antibody Is an Allosteric Insulin Receptor Antagonist That Induces Insulin Resistance.Impact of Cell-surface Antigen Expression on Target Engagement and Function of an Epidermal Growth Factor Receptor × c-MET Bispecific Antibody.Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7.Expression and purification of human TRPV1 in baculovirus-infected insect cells for structural studies.Fc Engineering Approaches to Enhance the Agonism and Effector Functions of an Anti-OX40 Antibody.Functional optimization of agonistic antibodies to OX40 receptor with novel Fc mutations to promote antibody multimerization.Ligand-induced changes in the Streptomyces lividans TipAL protein imply an alternative mechanism of transcriptional activation for MerR-like proteins.Rat cytochrome P450C24 (CYP24A1) and the role of F249 in substrate binding and catalytic activity.Correlation between the steric bulk of the distal E7 and E11 residues and the tilt of the FeCN unit in cyanometmyoglobin as determined by NMR from the orientation of the magnetic axes in single and double point mutants.1H NMR study of the solution molecular and electronic structure of Escherichia coli ferricytochrome b562: evidence for S = 1/2 in equilibrium S = 5/2 spin equilibrium for intact His/Met ligation.Diffusion of Soluble Aggregates of THIOMABs and Bispecific Antibodies in Serum.Lipidic Cubic Phases: New Matrices for the Three-Dimensional Crystallization of Membrane Proteins.Quantification of TRPV1 protein levels in rat tissues to understand its physiological roles.FcγRII-binding Centyrins mediate agonism and antibody-dependent cellular phagocytosis when fused to an anti-OX40 antibody.Unique pharmacology of a novel allosteric agonist/sensitizer insulin receptor monoclonal antibody.High-throughput assay for measuring monoclonal antibody self-association and aggregation in serum.An efficient process of generating bispecific antibodies via controlled Fab-arm exchange using culture supernatants.The heme iron coordination complex in His64(E7)Tyr recombinant sperm whale myoglobin.Broad spectrum thiopeptide recognition specificity of the Streptomyces lividans TipAL protein and its role in regulating gene expression.A Novel Bispecific Antibody Targeting EGFR and cMet Is Effective against EGFR Inhibitor-Resistant Lung Tumors.Development of ELISA to measure TRPV1 protein in rat tissues.Crystallization of bacteriorhodopsin solubilized by a tripod amphiphile.1H and 15N resonance assignments and secondary structure of the carbon monoxide complex of sperm whale myoglobinCharacterization of the covalent binding of thiostrepton to a thiostrepton-induced protein from Streptomyces lividansCrystallization in cubo: general applicability to membrane proteinsAntibody Structure and Function: The Basis for Engineering Therapeutics
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description
hulumtues
@sq
researcher
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wetenschapper
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հետազոտող
@hy
name
Mark L Chiu
@ast
Mark L Chiu
@en
Mark L Chiu
@es
Mark L Chiu
@fr
Mark L Chiu
@nl
Mark L Chiu
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type
label
Mark L Chiu
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Mark L Chiu
@en
Mark L Chiu
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Mark L Chiu
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Mark L Chiu
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Mark L Chiu
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prefLabel
Mark L Chiu
@ast
Mark L Chiu
@en
Mark L Chiu
@es
Mark L Chiu
@fr
Mark L Chiu
@nl
Mark L Chiu
@sl
P106
P21
P31
P496
0000-0001-6300-404X