Targeting PKC-mediated signal transduction pathways using enzastaurin to promote apoptosis in acute myeloid leukemia-derived cell lines and blast cells - Wikidata - awgldk - TriplyDB

Targeting PKC-mediated signal transduction pathways using enzastaurin to promote apoptosis in acute myeloid leukemia-derived cell lines and blast cells

Targeting PKC-mediated signal transduction pathways using enzastaurin to promote apoptosis in acute myeloid leukemia-derived cell lines and blast cells

http://www.wikidata.org/entity/Q39584277

about

Role of calcium-dependent protein kinases in chronic myeloid leukemia: combined effects of PKC and BCR-ABL signaling on cellular alterations during leukemia development Application of multiplexed kinase inhibitor beads to study kinome adaptations in drug-resistant leukemia The novel phospholipid mimetic KPC34 is highly active against preclinical models of Philadelphia chromosome positive acute lymphoblastic leukemia.Evaluation of apoptosis induction by concomitant inhibition of MEK, mTOR, and Bcl-2 in human acute myelogenous leukemia cells.Induction of heme oxygenase-1 by Na+-H+ exchanger 1 protein plays a crucial role in imatinib-resistant chronic myeloid leukemia cells.A deleterious gene-by-environment interaction imposed by calcium channel blockers in Marfan syndrome.IL-32θ gene expression in acute myeloid leukemia suppresses TNF-α production.High-Throughput Phenotypic Screening of Human Astrocytes to Identify Compounds That Protect Against Oxidative Stress.Tetraspanin CD82 Regulates the Spatiotemporal Dynamics of PKCα in Acute Myeloid Leukemia miR-150 exerts antileukemia activity in vitro and in vivo through regulating genes in multiple pathways Phosphoproteomic analysis of leukemia cells under basal and drug-treated conditions identifies markers of kinase pathway activation and mechanisms of resistance.IL-32θ: a recently identified anti-inflammatory variant of IL-32 and its preventive role in various disorders and tumor suppressor activity.Protein kinase C expression is deregulated in chronic lymphocytic leukemia.Protein Kinase C (PKC) Isozymes and Cancer

P2860

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P2860

Targeting PKC-mediated signal transduction pathways using enzastaurin to promote apoptosis in acute myeloid leukemia-derived cell lines and blast cells

http://www.wikidata.org/entity/Q39584277

description

2011 nî lūn-bûn

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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name

Targeting PKC-mediated signal ...... ved cell lines and blast cells

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Targeting PKC-mediated signal ...... ed cell lines and blast cells.

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type

label

Targeting PKC-mediated signal ...... ved cell lines and blast cells

@en

Targeting PKC-mediated signal ...... ed cell lines and blast cells.

@nl

prefLabel

Targeting PKC-mediated signal ...... ved cell lines and blast cells

@en

Targeting PKC-mediated signal ...... ed cell lines and blast cells.

@nl

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Journal of Cellular Biochemistry

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Targeting PKC-mediated signal ...... ved cell lines and blast cells

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P2093

Jared K Burks

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Julie C Watt

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Liran Zhou

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Peter P Ruvolo

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Steven Kornblau

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Tilahun Jiffar

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Vivian R Ruvolo

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P2860

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid

Direct binding to ceramide activates protein kinase Czeta before the formation of a pro-apoptotic complex with PAR-4 in differentiating stem cells

Protein kinase C: poised to signal

Reversible phosphorylation of Bcl2 following interleukin 3 or bryostatin 1 is mediated by direct interaction with protein phosphatase 2A

Signal transduction, cell cycle regulatory, and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells: possible sites for intervention with anti-neoplastic drugs

Regulation of Bcl2 phosphorylation and potential significance for leukemic cell chemoresistance.

Phase I and pharmacokinetic study of PKC412, an inhibitor of protein kinase C.

A phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory mantle cell lymphoma.

Phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory diffuse large B-cell lymphoma.

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1696-1707

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10.1002/JCB.23090

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6

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112

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Marina Konopleva

Michael Andreeff

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2011-06-01T00:00:00Z

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50229537

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21360576

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