MPTP: a neurotoxin relevant to the pathophysiology of Parkinson's disease. The 1985 George C. Cotzias lecture.
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A human synaptic vesicle monoamine transporter cDNA predicts posttranslational modifications, reveals chromosome 10 gene localization and identifies TaqI RFLPsVesicular monoamine transporter 2: role as a novel target for drug developmentMelatoninergic System in Parkinson's Disease: From Neuroprotection to the Management of Motor and Nonmotor SymptomsImportance of monoamine oxidase A in the bioactivation of neurotoxic analogs of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridineTreatment of early Parkinson's disease.Reduced noradrenergic innervation of ventral midbrain dopaminergic cell groups and the subthalamic nucleus in MPTP-treated parkinsonian monkeys.PET analysis of dopaminergic neurodegeneration in relation to immobility in the MPTP-treated common marmoset, a model for Parkinson's disease.Correlation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity with blood-brain barrier monoamine oxidase activity.An in vitro model of 1-methyl-4-phenyl-pyridinium (MPP+) toxicity: incubation of rabbit caudate nucleus slices with MPP+ followed by biochemical and functional analysis.Chimeric dopamine-norepinephrine transporters delineate structural domains influencing selectivity for catecholamines and 1-methyl-4-phenylpyridiniumRegional dopamine transporter gene expression in the substantia nigra from control and Parkinson's disease brains.Implications of co-morbidity for etiology and treatment of neurodegenerative diseases with multifunctional neuroprotective-neurorescue drugs; ladostigil.Anatomy, pigmentation, ventral and dorsal subpopulations of the substantia nigra, and differential cell death in Parkinson's disease.Dopamine transporter mutant mice in experimental neuropharmacology.Dopamine transporter site-directed mutations differentially alter substrate transport and cocaine bindingDifferential vulnerability of primate caudate-putamen and striosome-matrix dopamine systems to the neurotoxic effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.The neurotoxicity of MPTP and the relevance to Parkinson's disease.The MPTP story: MAO activates tetrahydropyridine derivatives to toxins causing parkinsonism.Neurotranmission systems as targets for toxicants: a review.The dopamine transporter carboxyl-terminal tail. Truncation/substitution mutants selectively confer high affinity dopamine uptake while attenuating recognition of the ligand binding domain.Some features of the nigrostriatal dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the mouse.Destabilization of survival factor MEF2D mRNA by neurotoxin in models of Parkinson's disease.Retroviral-mediated gene transfer. Applications in neurobiology.Rural or urban living and Parkinson's disease.Multi target neuroprotective and neurorestorative anti-Parkinson and anti-Alzheimer drugs ladostigil and m30 derived from rasagiline.MPTP's pathway of toxicity indicates central role of transcription factor SP1.Uptake of 1-methyl-4-phenylpyridinium and dopamine in the mouse brain cell nuclei.Peripheral blood cell activities of monoamine oxidase B and superoxide dismutase in Parkinson's disease.Detailed genotyping demonstrates association between the slow acetylator genotype for N-acetyltransferase 2 (NAT2) and familial Parkinson's disease.Rarity of debrisoquine hydroxylase gene polymorphism in Chinese patients with Parkinson's disease.Serotonergic sprouting in primate MTP-induced hemiparkinsonism.Genetic susceptibility to Parkinson's disease among South and North Indians: I. Role of polymorphisms in dopamine receptor and transporter genes and association of DRD4 120-bp duplication marker.Neurotoxicity of an MPTP analogue, 2'CH3-MPTP, on monoaminergic systems in the mouse brain.
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MPTP: a neurotoxin relevant to the pathophysiology of Parkinson's disease. The 1985 George C. Cotzias lecture.
description
1986 nî lūn-bûn
@nan
1986年の論文
@ja
1986年論文
@yue
1986年論文
@zh-hant
1986年論文
@zh-hk
1986年論文
@zh-mo
1986年論文
@zh-tw
1986年论文
@wuu
1986年论文
@zh
1986年论文
@zh-cn
name
MPTP: a neurotoxin relevant to ...... 985 George C. Cotzias lecture.
@en
MPTP: a neurotoxin relevant to ...... 985 George C. Cotzias lecture.
@nl
type
label
MPTP: a neurotoxin relevant to ...... 985 George C. Cotzias lecture.
@en
MPTP: a neurotoxin relevant to ...... 985 George C. Cotzias lecture.
@nl
prefLabel
MPTP: a neurotoxin relevant to ...... 985 George C. Cotzias lecture.
@en
MPTP: a neurotoxin relevant to ...... 985 George C. Cotzias lecture.
@nl
P356
P1433
P1476
MPTP: a neurotoxin relevant to ...... 985 George C. Cotzias lecture.
@en
P2093
P304
P356
10.1212/WNL.36.2.250
P407
P577
1986-02-01T00:00:00Z