Characterization and epitope mapping of neutralizing monoclonal antibodies produced by immunization with oligomeric simian immunodeficiency virus envelope protein
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Differential N-linked glycosylation of human immunodeficiency virus and Ebola virus envelope glycoproteins modulates interactions with DC-SIGN and DC-SIGNRMolecular architectures of trimeric SIV and HIV-1 envelope glycoproteins on intact viruses: strain-dependent variation in quaternary structureAiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidatesNovel monoclonal antibody directed at the receptor binding site on the avian sarcoma and leukosis virus Env complexOligomeric structure of virion-associated and soluble forms of the simian immunodeficiency virus envelope protein in the prefusion activated conformationKinetic rates of antibody binding correlate with neutralization sensitivity of variant simian immunodeficiency virus strainsIdentification of two N-linked glycosylation sites within the core of the simian immunodeficiency virus glycoprotein whose removal enhances sensitivity to soluble CD4.Three-dimensional structures of soluble CD4-bound states of trimeric simian immunodeficiency virus envelope glycoproteins determined by using cryo-electron tomographyAIDS vaccination studies using an ex vivo feline immunodeficiency virus model: failure to protect and possible enhancement of challenge infection by four cell-based vaccines prepared with autologous lymphoblastsRapid progression to simian AIDS can be accompanied by selection of CD4-independent gp120 variants with impaired ability to bind CD4.Nature of nonfunctional envelope proteins on the surface of human immunodeficiency virus type 1.Identification of gp120 binding sites on CXCR4 by using CD4-independent human immunodeficiency virus type 2 Env proteins.Changes in the immunogenic properties of soluble gp140 human immunodeficiency virus envelope constructs upon partial deletion of the second hypervariable regionEnhancement of mucosal immunization with virus-like particles of simian immunodeficiency virusRemoval of N-linked glycosylation sites in the V1 region of simian immunodeficiency virus gp120 results in redirection of B-cell responses to V3.Whole-body immunoPET reveals active SIV dynamics in viremic and antiretroviral therapy-treated macaques.Targeted Isolation of Antibodies Directed against Major Sites of SIV Env Vulnerability.A comparative immunogenicity study of HIV-1 virus-like particles bearing various forms of envelope proteins, particles bearing no envelope and soluble monomeric gp120.Mucosal immunization with virus-like particles of simian immunodeficiency virus conjugated with cholera toxin subunit B.Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidates.Conformational epitope consisting of the V3 and V4 loops as a target for potent and broad neutralization of simian immunodeficiency viruses.Relationship of HIV-1 and SIV envelope glycoprotein trimer occupation and neutralizationDerivation and Characterization of a CD4-Independent, Non-CD4-Tropic Simian Immunodeficiency Virus.Importance of the V1/V2 loop region of simian-human immunodeficiency virus envelope glycoprotein gp120 in determining the strain specificity of the neutralizing antibody response.Promoting trimerization of soluble human immunodeficiency virus type 1 (HIV-1) Env through the use of HIV-1/simian immunodeficiency virus chimeras.CD4+ T cells support production of simian immunodeficiency virus Env antibodies that enforce CD4-dependent entry and shape tropism in vivo.Derivation and Characterization of Pathogenic Transmitted/Founder Molecular Clones from Simian Immunodeficiency Virus SIVsmE660 and SIVmac251 following Mucosal Infection.Derivation and characterization of a simian immunodeficiency virus SIVmac239 variant with tropism for CXCR4.A chimeric protein of simian immunodeficiency virus envelope glycoprotein gp140 and Escherichia coli aspartate transcarbamoylase.Intranasal immunization with inactivated influenza virus enhances immune responses to coadministered simian-human immunodeficiency virus-like particle antigens.Virion Background and Efficiency of Virion Incorporation Determine Susceptibility of Simian Immunodeficiency Virus Env-Driven Viral Entry to Inhibition by IFITM Proteins.Restraining the conformation of HIV-1 gp120 by removing a flexible loop.Loss of a conserved N-linked glycosylation site in the simian immunodeficiency virus envelope glycoprotein V2 region enhances macrophage tropism by increasing CD4-independent cell-to-cell transmission.CD4 independence of simian immunodeficiency virus Envs is associated with macrophage tropism, neutralization sensitivity, and attenuated pathogenicity.HIV-1 virus-like particles bearing pure env trimers expose neutralizing epitopes but occlude nonneutralizing epitopes.Flow cytometry based identification of simian immunodeficiency virus Env-specific B lymphocytes.Identification and characterization of a macrophage-tropic SIV envelope glycoprotein variant in blood from early infection in SIVmac251-infected macaques.Oligomeric and conformational properties of a proteolytically mature, disulfide-stabilized human immunodeficiency virus type 1 gp140 envelope glycoprotein.Assorted mutations in the envelope gene of simian immunodeficiency virus lead to loss of neutralization resistance against antibodies representing a broad spectrum of specificities.Infectivity and neutralization of simian immunodeficiency virus with FLAG epitope insertion in gp120 variable loops.
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P2860
Characterization and epitope mapping of neutralizing monoclonal antibodies produced by immunization with oligomeric simian immunodeficiency virus envelope protein
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
Characterization and epitope m ...... iciency virus envelope protein
@en
Characterization and epitope m ...... ciency virus envelope protein.
@nl
type
label
Characterization and epitope m ...... iciency virus envelope protein
@en
Characterization and epitope m ...... ciency virus envelope protein.
@nl
prefLabel
Characterization and epitope m ...... iciency virus envelope protein
@en
Characterization and epitope m ...... ciency virus envelope protein.
@nl
P2093
P2860
P921
P1433
P1476
Characterization and epitope m ...... iciency virus envelope protein
@en
P2093
A L Edinger
B Haggarty
K C Baxter
P2860
P304
P356
10.1128/JVI.74.17.7922-7935.2000
P407
P577
2000-09-01T00:00:00Z