about
Inhibition of HIV-1 replication by RNA targeted against the LTR regionRationally designed interfacial peptides are efficient in vitro inhibitors of HIV-1 capsid assembly with antiviral activityHIV-1 protease catalytic efficiency effects caused by random single amino acid substitutions.IL28B SNP rs8099917 is strongly associated with pegylated interferon-α and ribavirin therapy treatment failure in HCV/HIV-1 coinfected patients.A bacteriophage lambda-based genetic screen for characterization of the activity and phenotype of the human immunodeficiency virus type 1 proteaseDeciphering the interleukin 28B variants that better predict response to pegylated interferon-α and ribavirin therapy in HCV/HIV-1 coinfected patientsInsertions in the reverse transcriptase increase both drug resistance and viral fitness in a human immunodeficiency virus type 1 isolate harboring the multi-nucleoside reverse transcriptase inhibitor resistance 69 insertion complex mutation.Role of the human immunodeficiency virus type 1 envelope gene in viral fitness.Epistasis as a determinant of the HIV-1 protease's robustness to mutationFitness variations and their impact on the evolution of antiretroviral drug resistance.Evolution subverting essentiality: dispensability of the cell attachment Arg-Gly-Asp motif in multiply passaged foot-and-mouth disease virus.Dilute passage promotes expression of genetic and phenotypic variants of human immunodeficiency virus type 1 in cell culture.Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents.Changes in codon-pair bias of human immunodeficiency virus type 1 have profound effects on virus replication in cell culture.HIV-1 reverse transcriptase inhibitor resistance mutations and fitness: a view from the clinic and ex vivo.Thymidine analogue resistance suppression by V75I of HIV-1 reverse transcriptase: effects of substituting valine 75 on stavudine excision and discrimination.Unfinished stories on viral quasispecies and Darwinian views of evolution.Deep sequencing: becoming a critical tool in clinical virology.Molecular determinants of multi-nucleoside analogue resistance in HIV-1 reverse transcriptases containing a dipeptide insertion in the fingers subdomain: effect of mutations D67N and T215Y on removal of thymidine nucleotide analogues from blocked DNSynonymous Virus Genome Recoding as a Tool to Impact Viral Fitness.Purifying selection of CCR5-tropic human immunodeficiency virus type 1 variants in AIDS subjects that have developed syncytium-inducing, CXCR4-tropic viruses.Molecular basis of the association of H208Y and thymidine analogue resistance mutations M41L, L210W and T215Y in the HIV-1 reverse transcriptase of treated patients.Rapid spread and genetic diversification of HIV type 1 subtype C in a rural area of southern Mozambique.Evolution of the human immunodeficiency virus type 1 protease: effects on viral replication capacity and protease robustness.Second-site reversion of a human immunodeficiency virus type 1 reverse transcriptase mutant that restores enzyme function and replication capacity.Mechanisms involved in the selection of HIV-1 reverse transcriptase thumb subdomain polymorphisms associated with nucleoside analogue therapy failure.Fate of direct and inverted repeats in the RNA hypermutagenesis reaction.Genetic screen for monitoring hepatitis C virus NS3 serine protease activity.Antigenic heterogeneity of a foot-and-mouth disease virus serotype in the field is mediated by very limited sequence variation at several antigenic sites.Evolution of the capsid protein genes of foot-and-mouth disease virus: antigenic variation without accumulation of amino acid substitutions over six decades.Fitness alteration of foot-and-mouth disease virus mutants: measurement of adaptability of viral quasispecies.Role of a dipeptide insertion between codons 69 and 70 of HIV-1 reverse transcriptase in the mechanism of AZT resistance.Reverse transcriptase and substrate dependence of the RNA hypermutagenesis reaction.Combination of a mutagenic agent with a reverse transcriptase inhibitor results in systematic inhibition of HIV-1 infection.New observations on antigenic diversification of RNA viruses. Antigenic variation is not dependent on immune selection.Relative replication fitness of multi-nucleoside analogue-resistant HIV-1 strains bearing a dipeptide insertion in the fingers subdomain of the reverse transcriptase and mutations at codons 67 and 215.Genetic screen for monitoring severe acute respiratory syndrome coronavirus 3C-like protease.Similarities between Human Immunodeficiency Virus Type 1 and Hepatitis C Virus Genetic and Phenotypic Protease Quasispecies Diversity.Exploring the functional robustness of an enzyme by in vitro evolutionDifferential restrictions on antigenic variation among antigenic sites of foot-and-mouth disease virus in the absence of antibody selection.
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Miguel A Martinez
@ast
Miguel A Martinez
@en
Miguel A Martinez
@es
Miguel A Martinez
@nl
Miguel A Martinez
@sl
type
label
Miguel A Martinez
@ast
Miguel A Martinez
@en
Miguel A Martinez
@es
Miguel A Martinez
@nl
Miguel A Martinez
@sl
prefLabel
Miguel A Martinez
@ast
Miguel A Martinez
@en
Miguel A Martinez
@es
Miguel A Martinez
@nl
Miguel A Martinez
@sl
P108
P1053
K-6435-2014
P106
P21
P31
P3829
P496
0000-0002-6681-4950