Targeting autophagy augments in vitro and in vivo antimyeloma activity of DNA-damaging chemotherapy.
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DangER: protein ovERload. Targeting protein degradation to treat myelomaAutophagy, autophagy-associated adaptive immune responses and its role in hematologic malignanciesDNA Damage Response and Autophagy: A Meaningful PartnershipPotential therapeutic approaches for modulating expression and accumulation of defective lamin A in laminopathies and age-related diseasesAutophagy inhibition for chemosensitization and radiosensitization in cancer: do the preclinical data support this therapeutic strategy?Autophagy and cancer therapy.Clioquinol induces pro-death autophagy in leukemia and myeloma cells by disrupting the mTOR signaling pathwayCalorie restriction combined with resveratrol induces autophagy and protects 26-month-old rat hearts from doxorubicin-induced toxicity20(S)-Ginsenoside Rg3 is a novel inhibitor of autophagy and sensitizes hepatocellular carcinoma to doxorubicinPhase I trial of hydroxychloroquine with dose-intense temozolomide in patients with advanced solid tumors and melanomaEffect of autophagy inhibition on chemotherapy-induced apoptosis in A549 lung cancer cells.Heat shock factor 1 confers resistance to Hsp90 inhibitors through p62/SQSTM1 expression and promotion of autophagic fluxDiscovery and development of small molecule SHIP phosphatase modulators.Inhibition of autophagy as a new means of improving chemotherapy efficiency in high-LC3B triple-negative breast cancersTargeting NAD+ salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition.Enhanced autophagy in cytarabine arabinoside-resistant U937 leukemia cells and its potential as a target for overcoming resistance.Autophagy inhibition enhances apigenin-induced apoptosis in human breast cancer cellsDeconvoluting the context-dependent role for autophagy in cancerHistone deacetylase 10 promotes autophagy-mediated cell survival.Antiestrogen-binding site ligands induce autophagy in myeloma cells that proceeds through alteration of cholesterol metabolismCSC-3436 switched tamoxifen-induced autophagy to apoptosis through the inhibition of AMPK/mTOR pathway.DNA repair pathways in human multiple myeloma: role in oncogenesis and potential targets for treatment.The activation of c-Jun NH₂-terminal kinase is required for dihydroartemisinin-induced autophagy in pancreatic cancer cells.Autophagy inhibition synergistically enhances anticancer efficacy of RAMBA, VN/12-1 in SKBR-3 cells, and tumor xenograftsThe proteasome: mechanisms of biology and markers of activity and response to treatment in multiple myeloma.Suppression of p53 potentiates chemosensitivity in nutrient-deprived cholangiocarcinoma cells via inhibition of autophagy.Activating autophagy to potentiate immunogenic chemotherapy and radiation therapy.Tenovin-6 inhibits proliferation and survival of diffuse large B-cell lymphoma cells by blocking autophagy.Research progress of hydroxychloroquine and autophagy inhibitors on cancer.Autophagy inhibition contributes to the synergistic interaction between EGCG and doxorubicin to kill the hepatoma Hep3B cells.The Complex Link between Apoptosis and Autophagy: a Promising New Role for RB.CD20 positive cells are undetectable in the majority of multiple myeloma cell lines and are not associated with a cancer stem cell phenotype.Three-dimensional tumor cell growth stimulates autophagic flux and recapitulates chemotherapy resistance.Modulating lysosomal function through lysosome membrane permeabilization or autophagy suppression restores sensitivity to cisplatin in refractory non-small-cell lung cancer cells.Double autophagy stimulation using chemotherapy and mTOR inhibition combined with hydroxychloroquine for autophagy modulation in patients with relapsed or refractory multiple myeloma.DNA damage response-initiated cytokine secretion in bone marrow stromal cells promotes chemoresistance of myeloma cells.Astragaloside II sensitizes human hepatocellular carcinoma cells to 5-fluorouracil via suppression of autophagy.Transcription factor EB is involved in autophagy-mediated chemoresistance to doxorubicin in human cancer cells.LMTK3 confers chemo-resistance in breast cancer.Low Beclin-1 expression predicts improved overall survival in patients treated with immunomodulatory drugs for multiple myeloma and identifies autophagy inhibition as a promising potentially druggable new therapeutic target: an analysis from The Aus
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P2860
Targeting autophagy augments in vitro and in vivo antimyeloma activity of DNA-damaging chemotherapy.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Targeting autophagy augments i ...... of DNA-damaging chemotherapy.
@en
Targeting autophagy augments i ...... of DNA-damaging chemotherapy.
@nl
type
label
Targeting autophagy augments i ...... of DNA-damaging chemotherapy.
@en
Targeting autophagy augments i ...... of DNA-damaging chemotherapy.
@nl
prefLabel
Targeting autophagy augments i ...... of DNA-damaging chemotherapy.
@en
Targeting autophagy augments i ...... of DNA-damaging chemotherapy.
@nl
P2093
P1476
Targeting autophagy augments i ...... of DNA-damaging chemotherapy.
@en
P2093
Baoxia Dong
Guangxun Gao
Hongjuan Dong
Liang Chen
Xiequn Chen
Yaozhu Pan
P304
P356
10.1158/1078-0432.CCR-10-0890
P407
P577
2011-02-02T00:00:00Z