Targeted ablation of glucose-dependent insulinotropic polypeptide-producing cells in transgenic mice reduces obesity and insulin resistance induced by a high fat diet.
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Structural and Pharmacological Characterization of Novel Potent and Selective Monoclonal Antibody Antagonists of Glucose-dependent Insulinotropic Polypeptide ReceptorNutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cellsChanges in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeabilityA GIP receptor agonist exhibits beta-cell anti-apoptotic actions in rat models of diabetes resulting in improved beta-cell function and glycemic control.Glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1: Incretin actions beyond the pancreas.GIP and GLP-1, the two incretin hormones: Similarities and differencesGlucose-dependent insulinotropic polypeptide signaling in pancreatic β-cells and adipocytesIncreased plasma levels of glucose-dependent insulinotropic polypeptide are associated with decreased postprandial energy expenditure after modern Japanese mealsThe effect of glucose-dependent insulinotropic polypeptide (GIP) variants on visceral fat accumulation in Han Chinese populationsXenin-25 potentiates glucose-dependent insulinotropic polypeptide action via a novel cholinergic relay mechanism.Glucose-dependent insulinotropic polypeptide stimulates the proliferation of colorectal cancer cells.Evolutionary conservation of glucose-dependent insulinotropic polypeptide (GIP) gene regulation and the enteroinsular axisExpression profiling identifies novel gene targets and functions for Pdx1 in the duodenum of mature mice.GIP-overexpressing mice demonstrate reduced diet-induced obesity and steatosis, and improved glucose homeostasisAdeno-associated viral serotypes produce differing titers and differentially transduce neurons within the rat basal and lateral amygdalaGlobal biochemical profiling identifies β-hydroxypyruvate as a potential mediator of type 2 diabetes in mice and humans.Transgenic rescue of adipocyte glucose-dependent insulinotropic polypeptide receptor expression restores high fat diet-induced body weight gain.Role of Gut-Related Peptides and Other Hormones in the Amelioration of Type 2 Diabetes after Roux-en-Y Gastric Bypass Surgery.Role of gut nutrient sensing in stimulating appetite and conditioning food preferences.Xenin-25 amplifies GIP-mediated insulin secretion in humans with normal and impaired glucose tolerance but not type 2 diabetes.Viral delivery of shRNA to amygdala neurons leads to neurotoxicity and deficits in Pavlovian fear conditioningXenin-25 increases cytosolic free calcium levels and acetylcholine release from a subset of myenteric neurons.Blockade of cannabinoid 1 receptor improves GLP-1R mediated insulin secretion in mice.Nogo-A downregulation improves insulin secretion in mice.The glucose-dependent insulinotropic polypeptide and glucose-stimulated insulin response to exercise training and diet in obesitySkin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity.Attenuated secretion of glucose-dependent insulinotropic polypeptide (GIP) does not alleviate hyperphagic obesity and insulin resistance in ob/ob miceMolecular mechanisms underlying nutrient-stimulated incretin secretion.Molecular mechanisms underlying nutrient detection by incretin-secreting cells.Therapeutic potential of the original incretin hormone glucose-dependent insulinotropic polypeptide: diabetes, obesity, osteoporosis and Alzheimer's disease?Nutrition and L and K-enteroendocrine cells.Using the lymphatics to study nutrient absorption and the secretion of gastrointestinal hormones.Glucose-dependent insulinotropic polypeptide: from pathophysiology to therapeutic opportunities in obesity-associated disorders.The effects of food components on hormonal signalling in gastrointestinal enteroendocrine cells.Peripheral signalling involved in energy homeostasis control.Incretins: their physiology and application in the treatment of diabetes mellitus.Active immunisation against gastric inhibitory polypeptide (GIP) improves blood glucose control in an animal model of obesity-diabetes.The Place of Dipeptidyl Peptidase-4 Inhibitors in Type 2 Diabetes Therapeutics: A "Me Too" or "the Special One" Antidiabetic Class?An enzymatically stable GIP/xenin hybrid peptide restores GIP sensitivity, enhances beta cell function and improves glucose homeostasis in high-fat-fed mice.Evogliptin: a new dipeptidyl peptidase inhibitor for the treatment of type 2 diabetes.
P2860
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P2860
Targeted ablation of glucose-dependent insulinotropic polypeptide-producing cells in transgenic mice reduces obesity and insulin resistance induced by a high fat diet.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Targeted ablation of glucose-d ...... ce induced by a high fat diet.
@en
Targeted ablation of glucose-d ...... ce induced by a high fat diet.
@nl
type
label
Targeted ablation of glucose-d ...... ce induced by a high fat diet.
@en
Targeted ablation of glucose-d ...... ce induced by a high fat diet.
@nl
prefLabel
Targeted ablation of glucose-d ...... ce induced by a high fat diet.
@en
Targeted ablation of glucose-d ...... ce induced by a high fat diet.
@nl
P2093
P2860
P356
P1476
Targeted ablation of glucose-d ...... ce induced by a high fat diet.
@en
P2093
Burton M Wice
Eric L Ford
Kenneth S Polonsky
Matthew C Althage
Patrick Tso
Songyan Wang
P2860
P304
18365-18376
P356
10.1074/JBC.M710466200
P407
P577
2008-04-17T00:00:00Z