Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling.
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Association of the protein-tyrosine phosphatase DEP-1 with its substrate FLT3 visualized by in situ proximity ligation assayIdentifying three-dimensional structures of autophosphorylation complexes in crystals of protein kinasesIn silico analyses reveal common cellular pathways affected by loss of heterozygosity (LOH) events in the lymphomagenesis of Non-Hodgkin's lymphoma (NHL).A quantitative assessment of costimulation and phosphatase activity on microclusters in early T cell signaling.The tyrosine kinase c-Met contributes to the pro-tumorigenic function of the p38 kinase in human bile duct cholangiocarcinoma cellsInteractions between Type III receptor tyrosine phosphatases and growth factor receptor tyrosine kinases regulate tracheal tube formation in Drosophila.Protein tyrosine phosphatase structure-function relationships in regulation and pathogenesis.Protein kinase C (PKC) as a drug target in chronic lymphocytic leukemia.R3 receptor tyrosine phosphatases: conserved regulators of receptor tyrosine kinase signaling and tubular organ development.Genetic alterations of protein tyrosine phosphatases in human cancers.Andrographolide Suppresses MV4-11 Cell Proliferation through the Inhibition of FLT3 Signaling, Fatty Acid Synthesis and Cellular Iron Uptake.Tumor Suppressor PTPRJ Is a Target of miR-155 in Colorectal Cancer.The protein-tyrosine phosphatase DEP-1 promotes migration and phagocytic activity of microglial cells in part through negative regulation of fyn tyrosine kinase.The protein tyrosine phosphatase DEP-1/PTPRJ promotes breast cancer cell invasion and metastasis.Molecular Pathways: Targeting Protein Tyrosine Phosphatases in Cancer.FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemiaKnockout of Density-Enhanced Phosphatase-1 impairs cerebrovascular reserve capacity in an arteriogenesis model in miceSynergistic killing of FLT3ITD-positive AML cells by combined inhibition of tyrosine-kinase activity and N-glycosylation.Expression of protein-tyrosine phosphatases in Acute Myeloid Leukemia cells: FLT3 ITD sustains high levels of DUSP6 expression.A genome-wide RNAi screen identifies proteins modulating aberrant FLT3-ITD signaling.Genomic instability is a principle pathologic feature of FLT3 ITD kinase activity in acute myeloid leukemia leading to clonal evolution and disease progression.NOX4-driven ROS formation mediates PTP inactivation and cell transformation in FLT3ITD-positive AML cells.The Src family kinase LCK cooperates with oncogenic FLT3/ITD in cellular transformation.High-resolution loss of heterozygosity screening implicates PTPRJ as a potential tumor suppressor gene that affects susceptibility to Non-Hodgkin's lymphoma.In Situ Proximity Ligation Assay (In Situ PLA) to Assess PTP-Protein Interactions.Receptor-type protein tyrosine phosphatase κ directly dephosphorylates CD133 and regulates downstream AKT activation.Hyperglycaemia-induced methylglyoxal accumulation potentiates VEGF resistance of diabetic monocytes through the aberrant activation of tyrosine phosphatase SHP-2/SRC kinase signalling axisSomatic inactivating PTPRJ mutations and dysregulated pathways identified in canine malignant melanoma by integrated comparative genomic analysis
P2860
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P2860
Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling.
@en
Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling.
@nl
type
label
Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling.
@en
Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling.
@nl
prefLabel
Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling.
@en
Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling.
@nl
P2093
P2860
P356
P1476
Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling.
@en
P2093
Deepika Arora
Elena Razumovskaya
Frank-D Böhmer
Julia Schons
Jörg P Müller
Kristina Masson
Lars Rönnstrand
Reinhard Bauer
Rinesh Godfrey
Sabine Stopp
P2860
P304
10918-10929
P356
10.1074/JBC.M110.205021
P407
P577
2011-01-24T00:00:00Z