Activation of nuclear factor-kappa B signalling promotes cellular senescence - Wikidata - awgldk - TriplyDB

Activation of nuclear factor-kappa B signalling promotes cellular senescence

Activation of nuclear factor-kappa B signalling promotes cellular senescence

http://www.wikidata.org/entity/Q39606649

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Pleiotropic cellular functions of PARP1 in longevity and aging: genome maintenance meets inflammation NF-κB in cellular senescence and cancer treatment Dynamic modelling of pathways to cellular senescence reveals strategies for targeted interventions Dietary Phytochemicals in Neuroimmunoaging: A New Therapeutic Possibility for Humans?Dexamethasone reduces sensitivity to cisplatin by blunting p53-dependent cellular senescence in non-small cell lung cancer Comparative Meta-Analysis of Transcriptomics Data during Cellular Senescence and In Vivo Tissue Ageing.Molecular mechanism of G1 arrest and cellular senescence induced by LEE011, a novel CDK4/CDK6 inhibitor, in leukemia cells.Increased FOXM1 expression can stimulate DNA repair in normal hepatocytes in vivo but also increases nuclear foci associated with senescence.An RNA interference screen for identifying downstream effectors of the p53 and pRB tumour suppressor pathways involved in senescence.SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1β.Cellular senescence and aging: the role of B-MYB Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity Opposing roles of NF-κB in anti-cancer treatment outcome unveiled by cross-species investigations.Human papillomavirus type 16 E6 and E 7 proteins alter NF-kB in cultured cervical epithelial cells and inhibition of NF-kB promotes cell growth and immortalization CLCA2 as a p53-inducible senescence mediator.TNFR-associated factor 6 and TGF-β-activated kinase 1 control signals for a senescence response by an endosomal NK cell receptor.Caveolin-1 deficiency protects from pulmonary fibrosis by modulating epithelial cell senescence in mice.The canonical NF-κB pathway differentially protects normal and human tumor cells from ROS-induced DNA damage Partial sleep deprivation activates the DNA damage response (DDR) and the senescence-associated secretory phenotype (SASP) in aged adult humans.Targeting aurora kinases limits tumour growth through DNA damage-mediated senescence and blockade of NF-κB impairs this drug-induced senescence.Novel functions of FoxM1: from molecular mechanisms to cancer therapy Metronomic topotecan impedes tumor growth of MYCN-amplified neuroblastoma cells in vitro and in vivo by therapy induced senescence.NF-κB functions in tumor initiation by suppressing the surveillance of both innate and adaptive immune cells Altered DNA base excision repair profile in brain tissue and blood in Alzheimer's disease NF-κB pathway activators as potential ageing biomarkers: targets for new therapeutic strategies.Sirtuins in neurodegenerative diseases: an update on potential mechanisms.NF-κB functions as a molecular link between tumor cells and Th1/Tc1 T cells in the tumor microenvironment to exert radiation-mediated tumor suppression.Sprouty1 induces a senescence-associated secretory phenotype by regulating NFκB activity: implications for tumorigenesis.Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype.The diverse and complex roles of NF-κB subunits in cancer.Friend or foe: emerging role of nuclear factor kappa-light-chain-enhancer of activated B cells in cell senescence.Telomeres, oxidative stress and inflammatory factors: partners in cellular senescence?Genetics of melanoma progression: the rise and fall of cell senescence.A combined approach against tumorigenesis using glucose deprivation and mitochondrial complex 1 inhibition by rotenone.Senescent cells: an emerging target for diseases of ageing.Deciphering the role of nuclear factor-κB in cellular senescence.Multiple myeloma causes clonal T-cell immunosenescence: identification of potential novel targets for promoting tumour immunity and implications for checkpoint blockade.ATRX is a regulator of therapy induced senescence in human cells.Regulation of p53 and Rb links the alternative NF-κB pathway to EZH2 expression and cell senescence.Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response

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P2860

Activation of nuclear factor-kappa B signalling promotes cellular senescence

http://www.wikidata.org/entity/Q39606649

description

2011 nî lūn-bûn

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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2011年论文

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2011年论文

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name

Activation of nuclear factor-kappa B signalling promotes cellular senescence

@en

Activation of nuclear factor-kappa B signalling promotes cellular senescence.

@nl

type

label

Activation of nuclear factor-kappa B signalling promotes cellular senescence

@en

Activation of nuclear factor-kappa B signalling promotes cellular senescence.

@nl

prefLabel

Activation of nuclear factor-kappa B signalling promotes cellular senescence

@en

Activation of nuclear factor-kappa B signalling promotes cellular senescence.

@nl

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C Caetano

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E Rovillain

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H Hummerich

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P2860

The Hallmarks of Cancer

Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase.

Feedback between p21 and reactive oxygen production is necessary for cell senescence

Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways

A large-scale RNAi screen in human cells identifies new components of the p53 pathway

Cytoscape: a software environment for integrated models of biomolecular interaction networks

miR-34a repression of SIRT1 regulates apoptosis

STRING 8--a global view on proteins and their functional interactions in 630 organisms

NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses

Motif module map reveals enforcement of aging by continual NF-kappaB activity

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2356-2366

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10.1038/ONC.2010.611

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20

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30

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René H. Medema

Mónica Alvarez

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2011-01-17T00:00:00Z

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49763098

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21242976

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3080811

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