Inhibition of human immunodeficiency virus type 1 Rev function by a dominant-negative mutant of Sam68 through sequestration of unspliced RNA at perinuclear bundles
about
Protein methylation is required to maintain optimal HIV-1 infectivitySam68 enhances the cytoplasmic utilization of intron-containing RNA and is functionally regulated by the nuclear kinase Sik/BRK.hRIP, a cellular cofactor for Rev function, promotes release of HIV RNAs from the perinuclear regionSam68 is absolutely required for Rev function and HIV-1 productionAltered localization and activity of the intracellular tyrosine kinase BRK/Sik in prostate tumor cellsSam68 is tyrosine phosphorylated and recruited to signalling in peripheral blood mononuclear cells from HIV infected patients.Specific interaction between Sam68 and neuronal mRNAs: implication for the activity-dependent biosynthesis of elongation factor eEF1A.Translational regulation of HIV-1 replication by HIV-1 Rev cellular cofactors Sam68, eIF5A, hRIP, and DDX3.Unperturbed posttranscriptional regulatory Rev protein function and HIV-1 replication in astrocytesA novel function for Sam68: enhancement of HIV-1 RNA 3' end processing.The retrovirus RNA trafficking granule: from birth to maturity.Sam68 relocalization into stress granules in response to oxidative stress through complexing with TIA-1Gene regulation at the RNA layer: RNA binding proteins in intercellular signaling networks.Nuclear Factor 90, a cellular dsRNA binding protein inhibits the HIV Rev-export function.hnRNP E1 and E2 have distinct roles in modulating HIV-1 gene expressionNuclear Protein Sam68 Interacts with the Enterovirus 71 Internal Ribosome Entry Site and Positively Regulates Viral Protein Translation.Analysis of the interaction between host factor Sam68 and viral elements during foot-and-mouth disease virus infectionsPrimary sequence and secondary structure motifs in spleen necrosis virus RU5 confer translational utilization of unspliced human immunodeficiency virus type 1 reporter RNA.Selective translational repression of HIV-1 RNA by Sam68DeltaC occurs by altering PABP1 binding to unspliced viral RNASuppression of HIV-1 Nef translation by Sam68 mutant-induced stress granules and nef mRNA sequestration.Mechanisms employed by retroviruses to exploit host factors for translational control of a complicated proteome.Role of Sam68 in post-transcriptional gene regulation.Sam68 functions in nuclear export and translation of HIV-1 RNA.Pokeweed antiviral protein alters splicing of HIV-1 RNAs, resulting in reduced virus production.Expression of exogenous Sam68, the 68-kilodalton SRC-associated protein in mitosis, is able to alleviate impaired Rev function in astrocytes.Direct participation of Sam68, the 68-kilodalton Src-associated protein in mitosis, in the CRM1-mediated Rev nuclear export pathwayStructural basis of RNA recognition and dimerization by the STAR proteins T-STAR and Sam68.Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression.The nuclear tyrosine kinase BRK/Sik phosphorylates and inhibits the RNA-binding activities of the Sam68-like mammalian proteins SLM-1 and SLM-2.The RNA binding protein Sam68 is acetylated in tumor cell lines, and its acetylation correlates with enhanced RNA binding activity.Inhibition of HIV-1 gene expression by Sam68 Delta C: multiple targets but a common mechanism?Detection of viral RNA by fluorescence in situ hybridization (FISH).
P2860
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P2860
Inhibition of human immunodeficiency virus type 1 Rev function by a dominant-negative mutant of Sam68 through sequestration of unspliced RNA at perinuclear bundles
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
Inhibition of human immunodefi ...... ced RNA at perinuclear bundles
@en
Inhibition of human immunodefi ...... ed RNA at perinuclear bundles.
@nl
type
label
Inhibition of human immunodefi ...... ced RNA at perinuclear bundles
@en
Inhibition of human immunodefi ...... ed RNA at perinuclear bundles.
@nl
prefLabel
Inhibition of human immunodefi ...... ced RNA at perinuclear bundles
@en
Inhibition of human immunodefi ...... ed RNA at perinuclear bundles.
@nl
P2093
P2860
P1433
P1476
Inhibition of human immunodefi ...... ced RNA at perinuclear bundles
@en
P2093
Carvajal HV
Cochrane AW
P2860
P304
P356
10.1128/JVI.75.17.8203-8215.2001
P407
P577
2001-09-01T00:00:00Z