Control of Aurora-A stability through interaction with TPX2. - Wikidata - awgldk - TriplyDB

Control of Aurora-A stability through interaction with TPX2.

Control of Aurora-A stability through interaction with TPX2.

http://www.wikidata.org/entity/Q39621507

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Targeting of MAPK-associated molecules identifies SON as a prime target to attenuate the proliferation and tumorigenicity of pancreatic cancer cells Non-centrosomal TPX2-Dependent Regulation of the Aurora A Kinase: Functional Implications for Healthy and Pathological Cell Division Ubiquitin-Mediated Degradation of Aurora Kinases Cross-Talk between AURKA and Plk1 in Mitotic Entry and Spindle Assembly Molecular mechanism of Aurora A kinase autophosphorylation and its allosteric activation by TPX2 NEDD9 depletion destabilizes Aurora A kinase and heightens the efficacy of Aurora A inhibitors: implications for treatment of metastatic solid tumors Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2 Identification of small molecule inhibitors of the Aurora-A/TPX2 complex Targeting TPX2 Suppresses the Tumorigenesis of Hepatocellular Carcinoma Cells Resulting in Arrested Mitotic Phase Progression and Increased Genomic Instability.Spatial regulation of Aurora A activity during mitotic spindle assembly requires RHAMM to correctly localize TPX2 Gene expression analysis reveals the cell cycle and kinetochore genes participating in ischemia reperfusion injury and early development in kidney.Essential role of the small GTPase Ran in postnatal pancreatic islet development.Issues in interpreting the in vivo activity of Aurora-A The essential role of evasion from cell death in cancer.Aurora-A inactivation causes mitotic spindle pole fragmentation by unbalancing microtubule-generated forces Phosphorylation of targeting protein for Xenopus kinesin-like protein 2 (TPX2) at threonine 72 in spindle assembly.A functional cooperativity between Aurora A kinase and LIM kinase1: implication in the mitotic process Mio depletion links mTOR regulation to Aurora A and Plk1 activation at mitotic centrosomes TPX2 regulates neuronal morphology through kinesin-5 interaction.Opposing Effects of Inhibitors of Aurora-A and EGFR in Autosomal-Dominant Polycystic Kidney Disease Aurora A kinase (AURKA) in normal and pathological cell division.Mitotic Stress and Chromosomal Instability in Cancer: The Case for TPX2.Chemically diverse microtubule stabilizing agents initiate distinct mitotic defects and dysregulated expression of key mitotic kinases Glioma pathogenesis-related protein 1 induces prostate cancer cell death through Hsc70-mediated suppression of AURKA and TPX2.TPX2: of spindle assembly, DNA damage response, and cancer.Building a Regulatory Network with Short Linear Sequence Motifs: Lessons from the Degrons of the Anaphase-Promoting Complex.Bcl2l10, a new Tpx2 binding partner, is a master regulator of Aurora kinase A in mouse oocytes.Common variation at BARD1 results in the expression of an oncogenic isoform that influences neuroblastoma susceptibility and oncogenicity.Haspin kinase regulates microtubule-organizing center clustering and stability through Aurora kinase C in mouse oocytes.Multifunctional human transcriptional coactivator protein PC4 is a substrate of Aurora kinases and activates the Aurora enzymes.A FRET biosensor reveals spatiotemporal activation and functions of aurora kinase A in living cells.Structural insight into TPX2-stimulated microtubule assembly.AURKA Activation by TPX2 Long residence times revealed by Aurora A kinase-targeting fluorescent probes derived from inhibitors MLN8237 and VX-689.Taxane-mediated radiosensitization derives from chromosomal missegregation on tripolar mitotic spindles orchestrated by AURKA and TPX2.NQO1 prevents radiation-induced aneuploidy by interacting with Aurora-A.

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P2860

Control of Aurora-A stability through interaction with TPX2.

http://www.wikidata.org/entity/Q39621507

description

2010 nî lūn-bûn

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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2010年论文

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2010年论文

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name

Control of Aurora-A stability through interaction with TPX2.

@en

Control of Aurora-A stability through interaction with TPX2.

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type

label

Control of Aurora-A stability through interaction with TPX2.

@en

Control of Aurora-A stability through interaction with TPX2.

@nl

prefLabel

Control of Aurora-A stability through interaction with TPX2.

@en

Control of Aurora-A stability through interaction with TPX2.

@nl

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P1433

Journal of Cell Science

P1476

Control of Aurora-A stability through interaction with TPX2

@en

P2093

Giulia Guarguaglini

http://www.w3.org/2001/XMLSchema#string

Italia A Asteriti

http://www.w3.org/2001/XMLSchema#string

Jacopo Scrofani

http://www.w3.org/2001/XMLSchema#string

Maria Giubettini

http://www.w3.org/2001/XMLSchema#string

P2860

Structural basis of Aurora-A activation by TPX2 at the mitotic spindle

Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A

Anaphase-promoting complex/cyclosome controls the stability of TPX2 during mitotic exit

Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

Human TPX2 is required for targeting Aurora-A kinase to the spindle

The mechanism of spindle assembly: functions of Ran and its target TPX2

Chromosome-induced microtubule assembly mediated by TPX2 is required for spindle formation in HeLa cells

hTPX2 is required for normal spindle morphology and centrosome integrity during vertebrate cell division

A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

Constitutive phosphorylation of aurora-a on ser51 induces its stabilization and consequent overexpression in cancer

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113-122

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scholarly article

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10.1242/JCS.075457

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P433

Pt 1

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124

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Catherine Lindon

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2010-12-08T00:00:00Z

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49673746

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21147853

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3001410

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