Novel cross-talk within the IKK family controls innate immunity.
about
MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascadesUnanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKε kinase-mediated antiviral responsePhosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophagesThe TLR and IL-1 signalling network at a glanceTank binding kinase 1 is a centrosome-associated kinase necessary for microtubule dynamics and mitosis.Molecular basis of Tank-binding kinase 1 activation by transautophosphorylationAt the interface of antioxidant signalling and cellular function: Key polyphenol effectsTRAF Family Member-associated NF-κB Activator (TANK) Inhibits Genotoxic Nuclear Factor κB Activation by Facilitating Deubiquitinase USP10-dependent Deubiquitination of TRAF6 LigaseThe IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signalingThe protein kinase TPL2 is essential for ERK1/ERK2 activation and cytokine gene expression in airway epithelial cells exposed to pathogen-associated molecular patterns (PAMPs)Investigation of salicylate hepatic responses in comparison with chemical analogues of the drugDynamic recruitment and activation of ALS-associated TBK1 with its target optineurin are required for efficient mitophagyPharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy.Differential Antagonism of Human Innate Immune Responses by Tick-Borne Phlebovirus Nonstructural Proteins.Detection of IKKε by immunohistochemistry in primary breast cancer: association with EGFR expression and absence of lymph node metastasis.IκB kinase-induced interaction of TPL-2 kinase with 14-3-3 is essential for Toll-like receptor activation of ERK-1 and -2 MAP kinasesEncephalomyocarditis virus 3C protease attenuates type I interferon production through disrupting the TANK-TBK1-IKKε-IRF3 complex.Porcine epidemic diarrhea virus nucleocapsid protein antagonizes beta interferon production by sequestering the interaction between IRF3 and TBK1.STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathwayAn inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in miceNEMO binds ubiquitinated TANK-binding kinase 1 (TBK1) to regulate innate immune responses to RNA viruses.Psoriasis mutations disrupt CARD14 autoinhibition promoting BCL10-MALT1-dependent NF-κB activation.TLR and TNF-R1 activation of the MKK3/MKK6-p38α axis in macrophages is mediated by TPL-2 kinase.Mechanism of endogenous regulation of the type I interferon response by suppressor of IκB kinase epsilon (SIKE), a novel substrate of TANK-binding kinase 1 (TBK1).Protein kinase IKKβ-catalyzed phosphorylation of IRF5 at Ser462 induces its dimerization and nuclear translocation in myeloid cells.Constitutive and ligand-induced EGFR signalling triggers distinct and mutually exclusive downstream signalling networks.A systematic analysis of the peripheral and CNS effects of systemic LPS, IL-1β, [corrected] TNF-α and IL-6 challenges in C57BL/6 miceIKKα negatively regulates ASC-dependent inflammasome activation.Regulation of T-cell activation and migration by the kinase TBK1 during neuroinflammationTRIM68 negatively regulates IFN-β production by degrading TRK fused gene, a novel driver of IFN-β downstream of anti-viral detection systemsThe TRAF-associated protein TANK facilitates cross-talk within the IkappaB kinase family during Toll-like receptor signaling.Inhibitors of the interferon response enhance virus replication in vitro.Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways.Intestinal intraepithelial lymphocyte activation promotes innate antiviral resistanceGene network inference and visualization tools for biologists: application to new human transcriptome datasets.Keap1 regulates inflammatory signaling in Mycobacterium avium-infected human macrophagesThe PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote MitophagyThe kinase TBK1 controls IgA class switching by negatively regulating noncanonical NF-κB signaling.IκB kinase 2 regulates TPL-2 activation of extracellular signal-regulated kinases 1 and 2 by direct phosphorylation of TPL-2 serine 400Molecular characterization, expression of chicken TBK1 gene and its effect on IRF3 signaling pathway
P2860
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P2860
Novel cross-talk within the IKK family controls innate immunity.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Novel cross-talk within the IKK family controls innate immunity.
@en
Novel cross-talk within the IKK family controls innate immunity.
@nl
type
label
Novel cross-talk within the IKK family controls innate immunity.
@en
Novel cross-talk within the IKK family controls innate immunity.
@nl
prefLabel
Novel cross-talk within the IKK family controls innate immunity.
@en
Novel cross-talk within the IKK family controls innate immunity.
@nl
P2093
P2860
P356
P1433
P1476
Novel cross-talk within the IKK family controls innate immunity.
@en
P2093
Edward G McIver
Erick R R Young
Jeffrey B Madwed
Joanne Hough
Kristopher Clark
Lorna Plater
Mark Peggie
Philip Cohen
Ronald J Sorcek
P2860
P304
P356
10.1042/BJ20101701
P407
P577
2011-02-01T00:00:00Z