BCR/ABL stimulates WRN to promote survival and genomic instability.
about
The Philadelphia chromosome in leukemogenesisThe role of RecQ helicases in non-homologous end-joiningBCR-ABL1 kinase inhibits uracil DNA glycosylase UNG2 to enhance oxidative DNA damage and stimulate genomic instability.RECQL1 and WRN DNA repair helicases: potential therapeutic targets and proliferative markers against cancers.Rac2-MRC-cIII-generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors.Chronic myelogenous leukemia stem and progenitor cells demonstrate chromosomal instability related to repeated breakage-fusion-bridge cycles mediated by increased nonhomologous end joiningDownregulation of the Werner syndrome protein induces a metabolic shift that compromises redox homeostasis and limits proliferation of cancer cells.Hydrogen peroxide: a Jekyll and Hyde signalling molecule.While at Rome miRNA and TRAIL do whatever BCR-ABL commands to do.Potential mechanisms of disease progression and management of advanced-phase chronic myeloid leukemia.Low-fidelity compensatory backup alternative DNA repair pathways may unify current carcinogenesis theories.Development of chronic myeloid leukaemia in patients treated with anti-VEGF therapies for clear cell renal cell cancer.Imatinib sensitivity in BCR-ABL1-positive chronic myeloid leukemia cells is regulated by the remaining normal ABL1 allele.Gene expression and mutation-guided synthetic lethality eradicates proliferating and quiescent leukemia cells.Heat shock protein 90 inhibitor is synergistic with JAK2 inhibitor and overcomes resistance to JAK2-TKI in human myeloproliferative neoplasm cells.Analysis of apoptosis methods recently used in Cancer Research and Cell Death & Disease publications.Genomic instability in chronic myeloid leukemia: targets for therapy?Investigation of Werner protein as an early DNA damage response in actinic keratosis, Bowen disease and squamous cell carcinoma.
P2860
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P2860
BCR/ABL stimulates WRN to promote survival and genomic instability.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
BCR/ABL stimulates WRN to promote survival and genomic instability.
@en
BCR/ABL stimulates WRN to promote survival and genomic instability.
@nl
type
label
BCR/ABL stimulates WRN to promote survival and genomic instability.
@en
BCR/ABL stimulates WRN to promote survival and genomic instability.
@nl
prefLabel
BCR/ABL stimulates WRN to promote survival and genomic instability.
@en
BCR/ABL stimulates WRN to promote survival and genomic instability.
@nl
P2093
P2860
P50
P1433
P1476
BCR/ABL stimulates WRN to promote survival and genomic instability
@en
P2093
Artur Slupianek
Dariusz Pytel
Kimberly Cramer
Michal O Nowicki
Stanislaw K Jozwiakowski
Tomasz Skorski
P2860
P304
P356
10.1158/0008-5472.CAN-10-1066
P407
P577
2010-12-01T00:00:00Z