S6K1 phosphorylates and regulates fragile X mental retardation protein (FMRP) with the neuronal protein synthesis-dependent mammalian target of rapamycin (mTOR) signaling cascade. - Wikidata - awgldk - TriplyDB

S6K1 phosphorylates and regulates fragile X mental retardation protein (FMRP) with the neuronal protein synthesis-dependent mammalian target of rapamycin (mTOR) signaling cascade.

S6K1 phosphorylates and regulates fragile X mental retardation protein (FMRP) with the neuronal protein synthesis-dependent mammalian target of rapamycin (mTOR) signaling cascade.

http://www.wikidata.org/entity/Q39627495

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Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function What can we learn about autism from studying fragile X syndrome?mTOR signaling: at the crossroads of plasticity, memory and disease Synaptic Plasticity, a Prominent Contributor to the Anxiety in Fragile X Syndrome RNA-binding proteins, neural development and the addictions Behavioral phenotypes of genetic mouse models of autism.The pathophysiology of fragile X (and what it teaches us about synapses)Targeted pharmacological treatment of autism spectrum disorders: fragile X and Rett syndromes The unstable repeats--three evolving faces of neurological disease Characterization of fragile X mental retardation protein recruitment and dynamics in Drosophila stress granules Therapeutic Strategies in Fragile X Syndrome: From Bench to Bedside and Back mTOR and MAPK: from localized translation control to epilepsy Subcellular fractionation and localization studies reveal a direct interaction of the fragile X mental retardation protein (FMRP) with nucleolin Roles of fragile X mental retardation protein in dopaminergic stimulation-induced synapse-associated protein synthesis and subsequent alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-4-propionate (AMPA) receptor internalization Positive feedback regulation of Akt-FMRP pathway protects neurons from cell death Dendritic mRNA targeting of Jacob and N-methyl-d-aspartate-induced nuclear translocation after calpain-mediated proteolysis Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures.Fragile X syndrome: mechanistic insights and therapeutic avenues regarding the role of potassium channels.Bidirectional regulation of dendritic voltage-gated potassium channels by the fragile X mental retardation protein CGG repeat in the FMR1 gene: size matters Potential therapeutic interventions for fragile X syndrome Single-molecule imaging of translational output from individual RNA granules in neurons.Autism as early neurodevelopmental disorder: evidence for an sAPPα-mediated anabolic pathway FMRP S499 is phosphorylated independent of mTORC1-S6K1 activity.ZBP1 phosphorylation at serine 181 regulates its dendritic transport and the development of dendritic trees of hippocampal neurons.Lithium: a promising treatment for fragile X syndrome.Necessary, but not sufficient: insights into the mechanisms of mGluR mediated long-term depression from a rat model of early life seizures Increasing our understanding of human cognition through the study of Fragile X Syndrome.Fragile X mental retardation protein expression in Alzheimer's disease Cellular stress-induced up-regulation of FMRP promotes cell survival by modulating PI3K-Akt phosphorylation cascades Association of the small GTPase Rheb with the NMDA receptor subunit NR3A.Frontier of epilepsy research - mTOR signaling pathway.Reversible inhibition of PSD-95 mRNA translation by miR-125a, FMRP phosphorylation, and mGluR signaling.The FMR1 gene and fragile X-associated tremor/ataxia syndrome.Mammalian target of rapamycin: hitting the bull's-eye for neurological disorders.Regulation of molecular pathways in the Fragile X Syndrome: insights into Autism Spectrum Disorders Mutations causing syndromic autism define an axis of synaptic pathophysiology.Targeted treatments for fragile X syndrome.In vivo neuronal function of the fragile X mental retardation protein is regulated by phosphorylation Genotype and cognitive phenotype of patients with tuberous sclerosis complex.

P2860

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P2860

S6K1 phosphorylates and regulates fragile X mental retardation protein (FMRP) with the neuronal protein synthesis-dependent mammalian target of rapamycin (mTOR) signaling cascade.

http://www.wikidata.org/entity/Q39627495

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

@zh-cn

name

S6K1 phosphorylates and regula ...... ycin (mTOR) signaling cascade.

@en

S6K1 phosphorylates and regulates fragile X mental retardation protein

@nl

type

label

S6K1 phosphorylates and regula ...... ycin (mTOR) signaling cascade.

@en

S6K1 phosphorylates and regulates fragile X mental retardation protein

@nl

prefLabel

S6K1 phosphorylates and regula ...... ycin (mTOR) signaling cascade.

@en

S6K1 phosphorylates and regulates fragile X mental retardation protein

@nl

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P1433

Journal of Biological Chemistry

P1476

S6K1 phosphorylates and regula ...... ycin (mTOR) signaling cascade.

@en

P2093

Gary J Bassell

http://www.w3.org/2001/XMLSchema#string

George Thomas

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Mika Nakamoto

http://www.w3.org/2001/XMLSchema#string

Stephanie Ceman

http://www.w3.org/2001/XMLSchema#string

Stephen T Warren

http://www.w3.org/2001/XMLSchema#string

Usha Narayanan

http://www.w3.org/2001/XMLSchema#string

Vijayalaxmi Nalavadi

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P2860

Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region

Cloning and characterization of p70(S6K beta) defines a novel family of p70 S6 kinases

Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex

Distinct protein phosphatase 2A heterotrimers modulate growth factor signaling to extracellular signal-regulated kinases and Akt

Mutational analysis of ribosomal S6 kinase 2 shows differential regulation of its kinase activity from that of ribosomal S6 kinase 1

Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases

S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway

Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice.

Fragile X mental retardation protein is translated near synapses in response to neurotransmitter activation

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

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18478-18482

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10.1074/JBC.C800055200

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27

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283

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2008-05-12T00:00:00Z

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18474609

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phosphorylation

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2441545

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