ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1 (mTORC1).
about
Osmotic stress regulates mammalian target of rapamycin (mTOR) complex 1 via c-Jun N-terminal Kinase (JNK)-mediated Raptor protein phosphorylationThe Ras-ERK and PI3K-mTOR pathways: cross-talk and compensationInsights into Chemoresistance of Prostate CancerTargeting translation initiation in breast cancerThe expanding role of mTOR in cancer cell growth and proliferationUbiquitin ligase TRIM3 controls hippocampal plasticity and learning by regulating synaptic γ-actin levelsEGFR/Ras Signaling Controls Drosophila Intestinal Stem Cell Proliferation via Capicua-Regulated GenesRecent Advances in Understanding Amino Acid Sensing Mechanisms that Regulate mTORC1Low concentrations of metformin selectively inhibit CD133⁺ cell proliferation in pancreatic cancer and have anticancer actionrpS6 regulates blood-testis barrier dynamics through Akt-mediated effects on MMP-9Gab2 phosphorylation by RSK inhibits Shp2 recruitment and cell motilityIntestinal cell kinase (ICK) promotes activation of mTOR complex 1 (mTORC1) through phosphorylation of Raptor Thr-908.MLN4924, an NAE inhibitor, suppresses AKT and mTOR signaling via upregulation of REDD1 in human myeloma cells.Regulation of blood-testis barrier (BTB) dynamics during spermatogenesis via the "Yin" and "Yang" effects of mammalian target of rapamycin complex 1 (mTORC1) and mTORC2.Absence of γ-sarcoglycan alters the response of p70S6 kinase to mechanical perturbation in murine skeletal muscle.Phosphoproteomic analysis identifies the tumor suppressor PDCD4 as a RSK substrate negatively regulated by 14-3-3.Calcineurin inhibitor-induced and Ras-mediated overexpression of VEGF in renal cancer cells involves mTOR through the regulation of PRAS40Mechanical stimulation induces mTOR signaling via an ERK-independent mechanism: implications for a direct activation of mTOR by phosphatidic acid.Anti-myeloma activity of Akt inhibition is linked to the activation status of PI3K/Akt and MEK/ERK pathway.Different patterns of Akt and ERK feedback activation in response to rapamycin, active-site mTOR inhibitors and metformin in pancreatic cancer cells.Growing knowledge of the mTOR signaling network.The identification of raptor as a substrate for p44/42 MAPKA new functional role for mechanistic/mammalian target of rapamycin complex 1 (mTORC1) in the circadian regulation of L-type voltage-gated calcium channels in avian cone photoreceptorsCombination of mTOR and EGFR kinase inhibitors blocks mTORC1 and mTORC2 kinase activity and suppresses the progression of colorectal carcinomaERK and Akt signaling pathways function through parallel mechanisms to promote mTORC1 signalingFrontier of epilepsy research - mTOR signaling pathway.Mammalian target of rapamycin complex I (mTORC1) activity in ras homologue enriched in brain (Rheb)-deficient mouse embryonic fibroblastsActivated α2-macroglobulin binding to cell surface GRP78 induces T-loop phosphorylation of Akt1 by PDK1 in association with Raptor.Short-term regulation of murine colonic NBCe1-B (electrogenic Na+/HCO3(-) cotransporter) membrane expression and activity by protein kinase C.The mechanism of insulin-stimulated 4E-BP protein binding to mammalian target of rapamycin (mTOR) complex 1 and its contribution to mTOR complex 1 signalingFoxc2 enhances proliferation and inhibits apoptosis through activating Akt/mTORC1 signaling pathway in mouse preadipocytes.Effectiveness of a combination therapy using calcineurin inhibitor and mTOR inhibitor in preventing allograft rejection and post-transplantation renal cancer progressionK-Ras mutation-mediated IGF-1-induced feedback ERK activation contributes to the rapalog resistance in pancreatic ductal adenocarcinomas.Receptor sequestration in response to β-arrestin-2 phosphorylation by ERK1/2 governs steady-state levels of GPCR cell-surface expression.GRP78/BiP is a novel downstream target of IGF-1 receptor mediated signaling.NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition.Transforming Growth Factor β1-induced Apoptosis in Podocytes via the Extracellular Signal-regulated Kinase-Mammalian Target of Rapamycin Complex 1-NADPH Oxidase 4 AxisRole of p70S6K1-mediated phosphorylation of eIF4B and PDCD4 proteins in the regulation of protein synthesis.Stimulatory effect of insulin on theca-interstitial cell proliferation and cell cycle regulatory proteins through MTORC1 dependent pathway.Comparing the transcriptomes of embryos from domesticated and wild Atlantic salmon (Salmo salar L.) stocks and examining factors that influence heritability of gene expression.
P2860
Q24614093-F2278D43-DA2C-44A0-B47F-097C74A73A47Q24616946-DEEC3DB5-9C3B-47C2-A344-166EF6115C55Q26795589-DC641A21-CA12-42F7-BD82-985C06FB9AC4Q27027284-09472A4A-D63F-4895-A41B-31031D5DD5E7Q27027797-1B29B095-C847-45EC-89F6-60885FE7DACCQ27309163-786766E3-591A-4F0B-B2FF-11E71E8DCAAFQ27310105-2C54E2FC-0F94-4163-BB33-24C9527C30F4Q28068298-B1E00CF7-FAE6-4FB2-9455-405F78D0AC72Q28487772-58B9D4E8-0BC0-4921-A148-21F43BB073F3Q28575120-746D6940-61C9-49D3-9394-7EE44478E61CQ28590764-CE9DEA65-E537-4746-A293-835644162A15Q30420049-EF0701B8-49C7-4B30-ADCC-5DA9F59FD83DQ33714747-9767F319-DBB4-4CB7-9B72-50222E862108Q33863571-81DF5A7C-FFA4-478F-84AC-0F2B22B9EE12Q33893451-13815C19-0E6F-45B0-AC7F-FF408394CE01Q33971905-C3C509EB-53E4-4B4E-A2A6-99F83B22B84AQ34009025-85FF05BC-8414-41D0-8242-17FED287BE70Q34450669-CDABC60A-BAED-48A1-AF23-DA42FBC5C46FQ34490880-CFF8F18E-FE56-4F87-A582-86D3749C2E64Q34600369-102D6F7A-3432-4B94-911D-64FAB8404097Q34620724-2EFE7242-8021-4D0D-B87B-B59A6F3DE3A7Q34696903-0AE89E55-E487-4557-A0BB-748CC58771D1Q34974206-65D4A71A-2ED3-4E3F-AA20-FAF22C341363Q34977124-D93079A5-3E63-48B2-B43C-C611AD2CEC7EQ34979291-C492F510-B973-4027-8F70-2107FEBF3EE9Q35014198-E88D115D-5CD9-469B-A58B-52E4FB77A3C5Q35058634-A5B05DFA-7F24-476F-ABE2-A56DEB389E3BQ35091716-45BF0201-F173-4ACE-BEED-4B28B40FA681Q35124063-2424FEF7-EC91-402B-9C40-3925FFC03BC2Q35515514-CCBA960A-1781-4068-B07B-8D5941399917Q35886271-69F18875-A240-4E00-83A0-928B2ABF1535Q35973628-228C4F7B-367E-468F-BD04-A87C83A1905BQ35992132-16B87EE3-2F6D-458F-A1D6-4E810A88CA6AQ36079140-42FEA93C-5B2B-4287-8EC8-02EC78720157Q36170215-4A045FBE-AA2A-441E-90DF-C0EF9E83303AQ36406372-73731C93-E7F2-4E68-B274-0636EDB04FBBQ36407247-1D41E010-7090-4550-AE9F-E9FD02408D0DQ36466762-17EF68CB-9A90-412A-934A-872E038B36C2Q36553215-D84B8E0A-8955-4CDE-8044-38B8B22C447EQ36701219-4A576521-E866-4A2D-BC27-8223EA4EC6A1
P2860
ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1 (mTORC1).
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
ERK1/2 phosphorylate Raptor to ...... on of mTOR complex 1 (mTORC1).
@en
ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1
@nl
type
label
ERK1/2 phosphorylate Raptor to ...... on of mTOR complex 1 (mTORC1).
@en
ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1
@nl
prefLabel
ERK1/2 phosphorylate Raptor to ...... on of mTOR complex 1 (mTORC1).
@en
ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1
@nl
P2093
P2860
P356
P1476
ERK1/2 phosphorylate Raptor to ...... ion of mTOR complex 1 (mTORC1)
@en
P2093
Diane C Fingar
Eric Bonneil
Hugo A Acosta-Jaquez
Julie Moreau
Pierre Thibault
Yves Romeo
P2860
P304
P356
10.1074/JBC.M110.159046
P407
P577
2010-11-11T00:00:00Z