Proteasome inhibitors decrease AAV2 capsid derived peptide epitope presentation on MHC class I following transduction. - Wikidata - awgldk - TriplyDB

Proteasome inhibitors decrease AAV2 capsid derived peptide epitope presentation on MHC class I following transduction.

Proteasome inhibitors decrease AAV2 capsid derived peptide epitope presentation on MHC class I following transduction.

http://www.wikidata.org/entity/Q39638928

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Proteasome inhibition is partially effective in attenuating pre-existing immunity against recombinant adeno-associated viral vectors Evaluation of engineered AAV capsids for hepatic factor IX gene transfer in murine and canine models The potential of adeno-associated viral vectors for gene delivery to muscle tissue.Cell-Mediated Immunity to AAV Vectors, Evolving Concepts and Potential Solutions.Proteasome inhibitors enhance gene delivery by AAV virus vectors expressing large genomes in hemophilia mouse and dog models: a strategy for broad clinical application.Adeno-associated virus (AAV) vectors in gene therapy: immune challenges and strategies to circumvent them.RETRACTED: Activation of the NF-kappaB pathway by adeno-associated virus (AAV) vectors and its implications in immune response and gene therapy Gene therapy for haemophilia: prospects and challenges to prevent or reverse inhibitor formation.Identification and Validation of Small Molecules That Enhance Recombinant Adeno-associated Virus Transduction following High-Throughput Screens.AAV-mediated gene targeting is significantly enhanced by transient inhibition of nonhomologous end joining or the proteasome in vivo AAV capsid CD8+ T-cell epitopes are highly conserved across AAV serotypes An Immune-Competent Murine Model to Study Elimination of AAV-Transduced Hepatocytes by Capsid-Specific CD8+ T Cells Site-Directed Mutagenesis of Surface-Exposed Lysine Residues Leads to Improved Transduction by AAV2, But Not AAV8, Vectors in Murine Hepatocytes In Vivo Adeno-associated virus capsid antigen presentation is dependent on endosomal escape.Engineered AAV vector minimizes in vivo targeting of transduced hepatocytes by capsid-specific CD8+ T cells.A survey of ex vivo/in vitro transduction efficiency of mammalian primary cells and cell lines with Nine natural adeno-associated virus (AAV1-9) and one engineered adeno-associated virus serotype Immune responses to AAV vectors: overcoming barriers to successful gene therapy Superior In vivo Transduction of Human Hepatocytes Using Engineered AAV3 Capsid.Targeted modifications in adeno-associated virus serotype 8 capsid improves its hepatic gene transfer efficiency in vivo Zinc-finger nuclease-mediated gene correction using single AAV vector transduction and enhancement by Food and Drug Administration-approved drugs.Postentry processing of recombinant adeno-associated virus type 1 and transduction of the ferret lung are altered by a factor in airway secretions.Role of antigen-specific regulatory CD4+CD25+ T cells in tolerance induction after neonatal IP administration of AAV-hF.IX.Effect of bortezomib on the efficacy of AAV9.SERCA2a treatment to preserve cardiac function in a rat pressure-overload model of heart failure.Pre-Clinical Assessment of Immune Responses to Adeno-Associated Virus (AAV) Vectors.Current status of haemophilia gene therapy.The Skeletal Muscle Environment and Its Role in Immunity and Tolerance to AAV Vector-Mediated Gene Transfer.Immortalized Human Hepatic Cell Lines for In Vitro Testing and Research Purposes.Adeno-Associated Virus (AAV) as a Vector for Gene Therapy.Liver-Directed Adeno-Associated Viral Gene Therapy for Hemophilia.Unraveling the complex story of immune responses to AAV vectors trial after trial.Optimized AAV rh.10 Vectors That Partially Evade Neutralizing Antibodies during Hepatic Gene Transfer.Human Bocavirus Type-1 Capsid Facilitates the Transduction of Ferret Airways by Adeno-Associated Virus Genomes.Plasmacytoid and conventional dendritic cells cooperate in crosspriming AAV capsid-specific CD8+ T cells.Improved adeno-associated virus (AAV) serotype 1 and 5 vectors for gene therapy.Impact of transduction towards the proliferation and migration as well as the transduction efficiency of human umbilical cord-derived late endothelial progenitor cells with nine recombinant adeno-associated virus serotypes.Effects of Cellular Methylation on Transgene Expression and Site-Specific Integration of Adeno-Associated Virus.Modulation of CD8+ T cell responses to AAV vectors with IgG-derived MHC class II epitopes Overcoming preexisting humoral immunity to AAV using capsid decoys Advances in Overcoming Immune Responses following Hemophilia Gene Therapy.Celastrol enhances AAV1-mediated gene expression in mice adipose tissues.

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P2860

Proteasome inhibitors decrease AAV2 capsid derived peptide epitope presentation on MHC class I following transduction.

http://www.wikidata.org/entity/Q39638928

description

2009 nî lūn-bûn

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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2009年论文

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2009年论文

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name

Proteasome inhibitors decrease ...... lass I following transduction.

@en

Proteasome inhibitors decrease ...... lass I following transduction.

@nl

type

label

Proteasome inhibitors decrease ...... lass I following transduction.

@en

Proteasome inhibitors decrease ...... lass I following transduction.

@nl

prefLabel

Proteasome inhibitors decrease ...... lass I following transduction.

@en

Proteasome inhibitors decrease ...... lass I following transduction.

@nl

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Molecular Therapy

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Proteasome inhibitors decrease ...... class I following transduction

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P2093

Daniel Hui

http://www.w3.org/2001/XMLSchema#string

Danielle Dunn

http://www.w3.org/2001/XMLSchema#string

Federico Mingozzi

http://www.w3.org/2001/XMLSchema#string

Gary C Pien

http://www.w3.org/2001/XMLSchema#string

Harre D Downey

http://www.w3.org/2001/XMLSchema#string

Jonathan D Finn

http://www.w3.org/2001/XMLSchema#string

Shangzhen Zhou

http://www.w3.org/2001/XMLSchema#string

P2860

Treatment of leber congenital amaurosis due to RPE65 mutations by ocular subretinal injection of adeno-associated virus gene vector: short-term results of a phase I trial

Safety and efficacy of gene transfer for Leber's congenital amaurosis

Effect of gene therapy on visual function in Leber's congenital amaurosis

TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells

Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response

Proteasome inhibition suppresses essential immune functions of human CD4+ T cells.

Endosomal processing limits gene transfer to polarized airway epithelia by adeno-associated virus.

On the role of proteasomes in cell biology and proteasome inhibition as a novel frontier in the development of immunosuppressants.

Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability.

Existence of transient functional double-stranded DNA intermediates during recombinant AAV transduction

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135-142

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10.1038/MT.2009.257

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1

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18

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Katherine A High

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2009-11-10T00:00:00Z

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38080830

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19904235

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2839204

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