Strains of [PSI(+)] are distinguished by their efficiencies of prion-mediated conformational conversion
about
Amyloid aggregates of the HET-s prion protein are infectious.Probing the role of PrP repeats in conformational conversion and amyloid assembly of chimeric yeast prionsThe [RNQ+] prion: a model of both functional and pathological amyloidMolecular structural basis for polymorphism in Alzheimer's -amyloid fibrilsSpontaneous variants of the [RNQ+] prion in yeast demonstrate the extensive conformational diversity possible with prion proteinsHeterologous cross-seeding mimics cross-species prion conversion in a yeast model.Optical trapping with high forces reveals unexpected behaviors of prion fibrils.Heterologous prion interactions are altered by mutations in the prion protein Rnq1p.Distinct prion strains are defined by amyloid core structure and chaperone binding site dynamics.Myopathy-causing mutations in an HSP40 chaperone disrupt processing of specific client conformers.Analysis of the [RNQ+] prion reveals stability of amyloid fibers as the key determinant of yeast prion variant propagation.Interactions among prions and prion "strains" in yeast.Changes in the middle region of Sup35 profoundly alter the nature of epigenetic inheritance for the yeast prion [PSI+]The [URE3] prion is not conserved among Saccharomyces speciesDestabilizing interactions among [PSI(+)] and [PIN(+)] yeast prion variants.Orientation of aromatic residues in amyloid cores: structural insights into prion fiber diversityPropagation of yeast prions.Importance of the Hsp70 ATPase domain in yeast prion propagationInsight into molecular basis of curing of [PSI+] prion by overexpression of 104-kDa heat shock protein (Hsp104).The 26S Proteasome Degrades the Soluble but Not the Fibrillar Form of the Yeast Prion Ure2p In Vitro.Prion protein repeat expansion results in increased aggregation and reveals phenotypic variability.A non-Q/N-rich prion domain of a foreign prion, [Het-s], can propagate as a prion in yeast.Prions in yeast.Wild yeast harbour a variety of distinct amyloid structures with strong prion-inducing capabilities.Structural variants of yeast prions show conformer-specific requirements for chaperone activity.[PSI(+) ] prion variant establishment in yeastThe elongation of yeast prion fibers involves separable steps of association and conversion.The same primary structure of the prion protein yields two distinct self-propagating states.An engineered nonsense URA3 allele provides a versatile system to detect the presence, absence and appearance of the [PSI+] prion in Saccharomyces cerevisiaePrion-prion interactionsExploring the basis of [PIN(+)] variant differences in [PSI(+)] inductionMutants of the Paf1 complex alter phenotypic expression of the yeast prion [PSI+]Sequestration of essential proteins causes prion associated toxicity in yeast.The genetic control of the formation and propagation of the [PSI+] prion of yeast.Variant-specific prion interactions: Complicating factors.Effects of Q/N-rich, polyQ, and non-polyQ amyloids on the de novo formation of the [PSI+] prion in yeast and aggregation of Sup35 in vitroDivergent prion strain evolution driven by PrPC expression level in transgenic mice.Amyloid oligomers: diffuse oligomer-based transmission of yeast prions.Patterns of [PSI (+) ] aggregation allow insights into cellular organization of yeast prion aggregates.Cell biology of yeast zygotes, from genesis to budding.
P2860
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P2860
Strains of [PSI(+)] are distinguished by their efficiencies of prion-mediated conformational conversion
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
Strains of [PSI
@nl
Strains of [PSI(+)] are distin ...... ated conformational conversion
@en
type
label
Strains of [PSI
@nl
Strains of [PSI(+)] are distin ...... ated conformational conversion
@en
prefLabel
Strains of [PSI
@nl
Strains of [PSI(+)] are distin ...... ated conformational conversion
@en
P2093
P2860
P356
P1433
P1476
Strains of [PSI(+)] are distin ...... ated conformational conversion
@en
P2093
G J Sawicki
S Lindquist
S M Uptain
P2860
P304
P356
10.1093/EMBOJ/20.22.6236
P407
P577
2001-11-01T00:00:00Z