The hominoid-specific oncogene TBC1D3 activates Ras and modulates epidermal growth factor receptor signaling and trafficking.
about
The clathrin heavy chain isoform CHC22 functions in a novel endosomal sorting stepNew genes contribute to genetic and phenotypic novelties in human evolutionTBC1D3, a hominoid-specific gene, delays IRS-1 degradation and promotes insulin signaling by modulating p70 S6 kinase activityCalmodulin promotes matrix metalloproteinase 9 production and cell migration by inhibiting the ubiquitination and degradation of TBC1D3 oncoprotein in human breast cancer cells.The evolution of human segmental duplications and the core duplicon hypothesis.Ubiquitination and degradation of the hominoid-specific oncoprotein TBC1D3 is mediated by CUL7 E3 ligaseNexus of signaling and endocytosis in oncogenesis driven by non-small cell lung cancer-associated epidermal growth factor receptor mutants.Endocytosis and intracellular trafficking of ErbBs.Cytoplasmic retention of a nucleocytoplasmic protein TBC1D3 by microtubule network is required for enhanced EGFR signalingWhole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways.Segmental duplications and evolutionary acquisition of UV damage response in the SPATA31 gene family of primates and humans.Evolutionary dynamism of the primate LRRC37 gene family.Copy number variation and evolution in humans and chimpanzeesPotential role of human-specific genes, human-specific microRNAs and human-specific non-coding regulatory RNAs in the pathogenesis of systemic sclerosis and Sjögren's syndrome.The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice.Human-specific genes may offer a unique window into human cell signalingUbiquitination and degradation of the hominoid-specific oncoprotein TBC1D3 is regulated by protein palmitoylationMice engrafted with human hematopoietic stem cells support a human myeloid cell inflammatory response in vivo.QuaDMutEx: quadratic driver mutation explorerEvolutionary origin and human-specific expansion of a cancer/testis antigen gene family.TBC1D3 associates with RAB5Human CCL3L1 copy number variation, gene expression, and the role of the CCL3L1-CCR5 axis in lung function.
P2860
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P2860
The hominoid-specific oncogene TBC1D3 activates Ras and modulates epidermal growth factor receptor signaling and trafficking.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
The hominoid-specific oncogene ...... tor signaling and trafficking.
@en
The hominoid-specific oncogene ...... tor signaling and trafficking.
@nl
type
label
The hominoid-specific oncogene ...... tor signaling and trafficking.
@en
The hominoid-specific oncogene ...... tor signaling and trafficking.
@nl
prefLabel
The hominoid-specific oncogene ...... tor signaling and trafficking.
@en
The hominoid-specific oncogene ...... tor signaling and trafficking.
@nl
P2093
P2860
P50
P356
P1476
The hominoid-specific oncogene ...... tor signaling and trafficking.
@en
P2093
Audra J Charron
M Alejandro Barbieri
Marisa J Wainszelbaum
Philip D Stahl
P2860
P304
13233-13242
P356
10.1074/JBC.M800234200
P407
P577
2008-03-04T00:00:00Z