Mitochondrial γ-secretase participates in the metabolism of mitochondria-associated amyloid precursor protein.
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Regulation of distinct pools of amyloid β-protein by multiple cellular proteasesNew Therapeutics to Modulate Mitochondrial Function in Neurodegenerative Disorders.Gamma-secretase-regulated proteolysis of the Notch receptor by mitochondrial intermediate peptidaseDecreased proteolytic activity of the mitochondrial amyloid-β degrading enzyme, PreP peptidasome, in Alzheimer's disease brain mitochondriaA mitochondrial etiology of Alzheimer and Parkinson diseaseAmyloid-β peptide binds to cytochrome C oxidase subunit 1.Amyloid-Beta interaction with mitochondriaThe Broad Impact of TOM40 on Neurodegenerative Diseases in AgingMitochondrial dysfunction and accumulation of the β-secretase-cleaved C-terminal fragment of APP in Alzheimer's disease transgenic miceMitochondrial dysfunction - the beginning of the end in Alzheimer's disease? Separate and synergistic modes of tau and amyloid-β toxicityIncreased neuronal PreP activity reduces Aβ accumulation, attenuates neuroinflammation and improves mitochondrial and synaptic function in Alzheimer disease's mouse modelMetabolic Characterization of Intact Cells Reveals Intracellular Amyloid Beta but Not Its Precursor Protein to Reduce Mitochondrial Respiration.Overexpression of amyloid-β protein precursor induces mitochondrial oxidative stress and activates the intrinsic apoptotic cascadeLost region in amyloid precursor protein (APP) through TALEN-mediated genome editing alters mitochondrial morphology.Localization and Processing of the Amyloid-β Protein Precursor in Mitochondria-Associated Membranes.Ca2+ dysfunction in neurodegenerative disorders: Alzheimer's disease.Inhibition of Poly(ADP-ribose) Polymerase-1 Enhances Gene Expression of Selected Sirtuins and APP Cleaving Enzymes in Amyloid Beta Cytotoxicity.Physical Exercise and Brain Mitochondrial Fitness: The Possible Role Against Alzheimer's Disease.Amyloid precursor protein processing and bioenergetics.FLZ inhibited γ-secretase selectively and decreased Aβ mitochondrial production in APP-SH-SY5Y cells.Towards Alzheimer's root cause: ECSIT as an integrating hub between oxidative stress, inflammation and mitochondrial dysfunction. Hypothetical role of the adapter protein ECSIT in familial and sporadic Alzheimer's disease pathogenesis.MH84: A Novel γ-Secretase Modulator/PPARγ Agonist--Improves Mitochondrial Dysfunction in a Cellular Model of Alzheimer's Disease.Interplay of Energetics and ER Stress Exacerbates Alzheimer's Amyloid-β (Aβ) Toxicity in Yeast.Genetic ablation of the p66Shc adaptor protein reverses cognitive deficits and improves mitochondrial function in an APP transgenic mouse model of Alzheimer's disease.Mitochondrial Perturbation in Alzheimer's Disease and Diabetes.Hydrogen Sulfide Selectively Inhibits γ-Secretase Activity and Decreases Mitochondrial Aβ Production in Neurons from APP/PS1 Transgenic Mice.Low cerebrospinal fluid concentration of mitochondrial DNA in preclinical Alzheimer disease.Low-density platelet populations demonstrate low in vivo activity in sporadic Alzheimer disease.A key role for MAM in mediating mitochondrial dysfunction in Alzheimer disease.Development of GMP-1 a molecular chaperone network modulator protecting mitochondrial function and its assessment in fly and mice models of Alzheimer's disease.
P2860
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P2860
Mitochondrial γ-secretase participates in the metabolism of mitochondria-associated amyloid precursor protein.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Mitochondrial γ-secretase part ...... ted amyloid precursor protein.
@en
Mitochondrial γ-secretase part ...... ted amyloid precursor protein.
@nl
type
label
Mitochondrial γ-secretase part ...... ted amyloid precursor protein.
@en
Mitochondrial γ-secretase part ...... ted amyloid precursor protein.
@nl
prefLabel
Mitochondrial γ-secretase part ...... ted amyloid precursor protein.
@en
Mitochondrial γ-secretase part ...... ted amyloid precursor protein.
@nl
P2093
P356
P1433
P1476
Mitochondrial γ-secretase part ...... ted amyloid precursor protein.
@en
P2093
Birgitta Wiehager
Homira Behbahani
Maria Ankarcrona
Pavel F Pavlov
Susanne Frykman
P356
10.1096/FJ.10-157230
P407
P577
2010-09-10T00:00:00Z