The zinc finger domain of NEMO is selectively required for NF-kappa B activation by UV radiation and topoisomerase inhibitors.
about
The IkappaB kinase complex: master regulator of NF-kappaB signalingWithaferin A disrupts ubiquitin-based NEMO reorganization induced by canonical NF-κB signalingSignals from within: the DNA-damage-induced NF-kappaB responseQuantification of cellular NEMO content and its impact on NF-κB activation by genotoxic stressThe interaction between AID and CIB1 is nonessential for antibody gene diversification by gene conversion or class switch recombinationInterleukin-1-induced NF-kappaB activation is NEMO-dependent but does not require IKKbetaThe regulatory logic of the NF-kappaB signaling system.Differential signaling circuits in regulation of ultraviolet C light-induced early- and late-phase activation of NF-κB.Stimulation of IKK-gamma oligomerization by the human T-cell leukemia virus oncoprotein Tax.Regulation of constitutive p50/c-Rel activity via proteasome inhibitor-resistant IkappaBalpha degradation in B cells.The role of constitutive nitric-oxide synthase in ultraviolet B light-induced nuclear factor κB activityTransforming growth factor-β1 induces matrix metalloproteinase-9 and cell migration in astrocytes: roles of ROS-dependent ERK- and JNK-NF-κB pathways.Covalent modification of the NF-κB essential modulator (NEMO) by a chemical compound can regulate its ubiquitin binding properties in vitro.Dendritic cells from humans with hypomorphic mutations in IKBKG/NEMO have impaired mitogen-activated protein kinase activity.IKKβ in postnatal perichondrium remotely controls endochondral ossification of the growth plate through downregulation of MCP-5.IPO3-mediated Nonclassical Nuclear Import of NF-κB Essential Modulator (NEMO) Drives DNA Damage-dependent NF-κB ActivationEvidence that the kinase-truncated c-Src regulates NF-κB signaling by targeting NEMO.NEMO ensures signaling specificity of the pleiotropic IKKβ by directing its kinase activity toward IκBα.NF-κB-dependent microRNA-125b up-regulation promotes cell survival by targeting p38α upon ultraviolet radiationQuantitative profiling of DNA damage and apoptotic pathways in UV damaged cells using PTMScan DirectProteasome inhibitors induce apoptosis of prostate cancer cells by inducing nuclear translocation of IkappaBalpha.Supreme EnLIGHTenment: damage recognition and signaling in the mammalian UV response.Phosphorylation of p53 by IkappaB kinase 2 promotes its degradation by beta-TrCP.The zinc finger domain of IKKγ (NEMO) protein in health and diseaseOld target new approach: an alternate NF-kappaB activation pathway via translation inhibition.Mechanism of UV-induced IkappaBalpha-independent activation of NF-kappaBNF-κB signaling.DNA damage-dependent NF-κB activation: NEMO turns nuclear signaling inside out.Signaling pathways targeted by curcumin in acute and chronic injury: burns and photo-damaged skin.Ultraviolet B radiation activates NF-κB and induces iNOS expression in HR-1 hairless mouse skin: role of IκB kinase-β.Logical network of genotoxic stress-induced NF-κB signal transduction predicts putative target structures for therapeutic intervention strategiesIdentifying post-translational modifications of NEMO by tandem mass spectrometry after high affinity purification.Tetrameric oligomerization of IkappaB kinase gamma (IKKgamma) is obligatory for IKK complex activity and NF-kappaB activationThe zinc finger of NEMO is a functional ubiquitin-binding domain.Identification of PP2A as a crucial regulator of the NF-kappaB feedback loop: its inhibition by UVB turns NF-kappaB into a pro-apoptotic factor.Phosphorylation of serine 68 in the IkappaB kinase (IKK)-binding domain of NEMO interferes with the structure of the IKK complex and tumor necrosis factor-alpha-induced NF-kappaB activity.Kaposi's sarcoma-associated herpesvirus induces sustained NF-kappaB activation during de novo infection of primary human dermal microvascular endothelial cells that is essential for viral gene expression.Calcium-dependent regulation of NEMO nuclear export in response to genotoxic stimuli.Proteasome inhibitors induce death but activate NF-kappaB on endometrial carcinoma cell lines and primary culture explants.A point mutation in NEMO associated with anhidrotic ectodermal dysplasia with immunodeficiency pathology results in destabilization of the oligomer and reduces lipopolysaccharide- and tumor necrosis factor-mediated NF-kappa B activation.
P2860
Q24313366-0FB89212-3F09-4270-B617-6C16A679E95DQ27302812-3AE233D6-8F4A-44BD-902A-78C7C4B6F798Q28291658-E87AD526-855A-4D81-82C9-BC9900D5A6F3Q28543866-FE6D4E19-8B18-47B7-8070-775F4C1A7387Q28750273-65AC8735-9386-4B85-B22C-5DA5E518E478Q33669288-F08DCCB3-B429-460C-B601-063F191A673AQ33685419-4FFA061C-80D0-42BC-B1D8-9681187DBE89Q34145906-BE746BA0-239C-4AF8-8C3E-5B31396E82C7Q34159321-33B3CC26-D471-4A4C-9C39-029A1B3025C6Q34182208-6EC6BACD-F0D1-4463-AEF8-9F90A01DB43EQ34249035-25F1EF14-EC2A-4E7E-BF0E-AE2B2BDE9893Q34408250-7B682F06-D984-4E72-9ADF-E2DE854807EFQ34580265-E8ED5736-3045-419A-9455-6B24901CB1FDQ35098644-3272C78D-5A3F-4450-9F5F-AA6A115A7E94Q35349586-826111D6-F645-41D8-8743-5A9E65C5EF00Q35859525-2616EC08-6734-46EB-9E23-C85BFC5BABBEQ35860261-6127FA02-B229-456C-ADDC-5F2BFDDACDBAQ36098755-43CA5657-286C-4514-B747-05451A0D0E82Q36294827-DA6099F4-CF64-4024-8D2E-155A6EAD6282Q36589890-EC00031C-A01F-422A-AE56-B4CAC9EB5B14Q36953274-BD351240-608F-4831-BA6D-4EFE744C74C6Q37086576-72AB30CB-60E0-45A2-ADEA-0EA92EA8894FQ37115176-8F7B3344-F93E-4784-B8B0-2BEB5C5739E2Q37295365-CBAE183D-52EE-4E06-AF3A-2163A65A34FEQ37338854-F68787E1-D194-481D-8B26-AF0D3DBDE35CQ37346602-3030CEE7-E6C8-4612-92EF-E1B059E892E8Q37691276-990B9CE4-3DCC-43FF-814A-0A871C93BE3EQ37995692-F791FD1E-3BCC-43B5-BE52-CB5F1636070DQ38066582-E4046187-5EE8-4399-B03A-0530F695B381Q38336119-22D75245-306C-4273-8C4B-CE9C40FE82BEQ38364071-E4DAB9E9-4126-4CBB-B13B-7571353F4EC1Q39098951-7207846C-0018-4B50-99AB-16B5FFB1B195Q39732418-45ECFCA2-3A10-4255-A18A-B7FC6B5DD9F7Q39912363-97436C07-05FA-41AF-9BD4-62F3E3D5396DQ39967736-6B214850-940B-464F-9B28-58ED82583024Q40058260-7108E5E4-04D1-4889-81E1-C7D66F6D2A44Q40173444-E7683D23-BCB7-4AC3-ACBE-0A7B7BBA3DB0Q40214079-EF102093-B389-4AEC-8A31-53469C66F18CQ40273672-A32FD4EB-B826-4B21-8F05-F3A700093EB1Q40335919-5A724FE1-2FD0-47FD-83EA-DCE253200D2E
P2860
The zinc finger domain of NEMO is selectively required for NF-kappa B activation by UV radiation and topoisomerase inhibitors.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
The zinc finger domain of NEMO ...... and topoisomerase inhibitors.
@en
The zinc finger domain of NEMO ...... and topoisomerase inhibitors.
@nl
type
label
The zinc finger domain of NEMO ...... and topoisomerase inhibitors.
@en
The zinc finger domain of NEMO ...... and topoisomerase inhibitors.
@nl
prefLabel
The zinc finger domain of NEMO ...... and topoisomerase inhibitors.
@en
The zinc finger domain of NEMO ...... and topoisomerase inhibitors.
@nl
P2093
P2860
P1476
The zinc finger domain of NEMO ...... n and topoisomerase inhibitors
@en
P2093
Shelby L Feinberg
Shigeki Miyamoto
Tony T Huang
P2860
P304
P356
10.1128/MCB.22.16.5813-5825.2002
P407
P577
2002-08-01T00:00:00Z