Mutagenic scan of the H-N-H motif of colicin E9: implications for the mechanistic enzymology of colicins, homing enzymes and apoptotic endonucleases.
about
Mutagenesis identifies the critical amino acid residues of human endonuclease G involved in catalysis, magnesium coordination, and substrate specificityZRANB3 is a structure-specific ATP-dependent endonuclease involved in replication stress responseColicin biologyMetal ions and phosphate binding in the H-N-H motif: Crystal structures of the nuclease domain of ColE7/Im7 in complex with a phosphate ion and different divalent metal ionsDNA binding and cleavage by the periplasmic nuclease Vvn: a novel structure with a known active siteCrystal structure of the -Me type II restriction endonuclease Hpy99I with target DNAThe crystal structure of the TolB box of colicin A in complex with TolB reveals important differences in the recruitment of the common TolB translocation portal used by group A colicinsAllosteric β-propeller signalling in TolB and its manipulation by translocating colicinsA new insight into the zinc-dependent DNA-cleavage by the colicin E7 nuclease: a crystallographic and computational studyCofactor requirement of HpyAV restriction endonucleaseThe evolution of reduced microbial killingFine tuning of the catalytic activity of colicin E7 nuclease domain by systematic N-terminal mutations.Structural basis for stable DNA complex formation by the caspase-activated DNase.In vivo processing of DNase colicins E2 and E7 is required for their import into the cytoplasm of target cells.P1 Ref Endonuclease: A Molecular Mechanism for Phage-Enhanced Antibiotic Lethality.Crystal structural analysis and metal-dependent stability and activity studies of the ColE7 endonuclease domain in complex with DNA/Zn2+ or inhibitor/Ni2+Characterization of Rv0888, a Novel Extracellular Nuclease from Mycobacterium tuberculosisRecA-dependent programmable endonuclease Ref cleaves DNA in two distinct steps.Transcriptional profiling of colicin-induced cell death of Escherichia coli MG1655 identifies potential mechanisms by which bacteriocins promote bacterial diversityType II restriction endonuclease R.KpnI is a member of the HNH nuclease superfamilyBacillus subtilis hlpB encodes a conserved stand-alone HNH nuclease-like protein that is essential for viability unless the hlpB deletion is accompanied by the deletion of genes encoding the AddAB DNA repair complex.Biochemical and mutagenic analysis of I-CreII reveals distinct but important roles for both the H-N-H and GIY-YIG motifsUropathogenic specific protein gene, highly distributed in extraintestinal uropathogenic Escherichia coli, encodes a new member of H-N-H nuclease superfamily.Distinct conformational stability and functional activity of four highly homologous endonuclease colicins.Rapid detection of colicin E9-induced DNA damage using Escherichia coli cells carrying SOS promoter-lux fusions.Identification of the catalytic motif of the microbial ribosome inactivating cytotoxin colicin E3.Destabilization of the colicin E9 Endonuclease domain by interaction with negatively charged phospholipids: implications for colicin translocation into bacteria.Structure-based analysis of the metal-dependent mechanism of H-N-H endonucleases.Structural insights into the mechanism of nuclease A, a betabeta alpha metal nuclease from Anabaena.Nuclease A (Gbs0661), an extracellular nuclease of Streptococcus agalactiae, attacks the neutrophil extracellular traps and is needed for full virulence.
P2860
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P2860
Mutagenic scan of the H-N-H motif of colicin E9: implications for the mechanistic enzymology of colicins, homing enzymes and apoptotic endonucleases.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Mutagenic scan of the H-N-H mo ...... s and apoptotic endonucleases.
@en
Mutagenic scan of the H-N-H mo ...... s and apoptotic endonucleases.
@nl
type
label
Mutagenic scan of the H-N-H mo ...... s and apoptotic endonucleases.
@en
Mutagenic scan of the H-N-H mo ...... s and apoptotic endonucleases.
@nl
prefLabel
Mutagenic scan of the H-N-H mo ...... s and apoptotic endonucleases.
@en
Mutagenic scan of the H-N-H mo ...... s and apoptotic endonucleases.
@nl
P2093
P2860
P356
P1476
Mutagenic scan of the H-N-H mo ...... s and apoptotic endonucleases.
@en
P2093
Ansgar J Pommer
Colin Kleanthous
David C Walker
Geoffrey R Moore
Richard James
Theonie Georgiou
P2860
P304
P356
10.1093/NAR/GKF420
P407
P577
2002-07-01T00:00:00Z