14-3-3 antagonizes Ras-mediated Raf-1 recruitment to the plasma membrane to maintain signaling fidelity.
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DYRK1A autophosphorylation on serine residue 520 modulates its kinase activity via 14-3-3 bindingImpaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signalingDistinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signallingRaf family kinases: old dogs have learned new tricksPhosphorylation of MEKK3 at threonine 294 promotes 14-3-3 association to inhibit nuclear factor kappaB activationPhosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking proteinFunctional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate.Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyondSmall-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) InterfaceDistribution, levels and phosphorylation of Raf-1 in Alzheimer's disease.Regulation of yeast Yak1 kinase by PKA and autophosphorylation-dependent 14-3-3 binding.14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform 1-binding protein that negatively regulates RSK kinase activityReproducible Analysis of Post-Translational Modifications in Proteomes--Application to Human MutationsPolarity proteins and cell-cell interactions in the testis.Sulfur dioxide inhibits vascular smooth muscle cell proliferation via suppressing the Erk/MAP kinase pathway mediated by cAMP/PKA signaling.IκB kinase-induced interaction of TPL-2 kinase with 14-3-3 is essential for Toll-like receptor activation of ERK-1 and -2 MAP kinasesA KSR/CNK complex mediated by HYP, a novel SAM domain-containing protein, regulates RAS-dependent RAF activation in Drosophila.Lysyl oxidase inhibits ras-mediated transformation by preventing activation of NF-kappa B.The role of intracellular signaling in insulin-mediated regulation of drug metabolizing enzyme gene and protein expression.The Ras-like protein R-Ras2/TC21 is important for proper mammary gland development.Role of melanoma inhibitor of apoptosis (ML-IAP) protein, a member of the baculoviral IAP repeat (BIR) domain family, in the regulation of C-RAF kinase and cell migrationIncreased BRAF heterodimerization is the common pathogenic mechanism for noonan syndrome-associated RAF1 mutantsSystem properties of ErbB receptor signaling for the understanding of cancer progression.Ras-mutant cancer cells display B-Raf binding to Ras that activates extracellular signal-regulated kinase and is inhibited by protein kinase A phosphorylation.Local cAMP signaling in disease at a glanceGenetic and physical interaction of Ssp1 CaMKK and Rad24 14-3-3 during low pH and osmotic stress in fission yeastMechanistic principles of RAF kinase signaling.Tumor adaptation and resistance to RAF inhibitors.SUMO in Drosophila Development.Contribution of the R-Ras2 GTP-binding protein to primary breast tumorigenesis and late-stage metastatic disease.Stimulation of neoplastic mouse lung cell proliferation by alveolar macrophage-derived, insulin-like growth factor-1 can be blocked by inhibiting MEK and PI3K activation.Inducible gene deletion reveals different roles for B-Raf and Raf-1 in B-cell antigen receptor signalling.Integrated modulation of phorbol ester-induced Raf activation in EL4 lymphoma cells.Bimodal regulation of RAF by CNK in Drosophila.Raf-1 serine 338 phosphorylation plays a key role in adhesion-dependent activation of extracellular signal-regulated kinase by epidermal growth factor.Phosphorylation of 338SSYY341 regulates specific interaction between Raf-1 and MEK1.Signaling specificity by Ras family GTPases is determined by the full spectrum of effectors they regulate.The requirement of specific membrane domains for Raf-1 phosphorylation and activation.Phosphorylation of Raf-1 by p21-activated kinase 1 and Src regulates Raf-1 autoinhibition.Membrane localization, oligomerization, and phosphorylation are required for optimal raf activation.
P2860
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P2860
14-3-3 antagonizes Ras-mediated Raf-1 recruitment to the plasma membrane to maintain signaling fidelity.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
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2002年學術文章
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2002年學術文章
@zh-hant
name
14-3-3 antagonizes Ras-mediate ...... o maintain signaling fidelity.
@en
14-3-3 antagonizes Ras-mediate ...... o maintain signaling fidelity.
@nl
type
label
14-3-3 antagonizes Ras-mediate ...... o maintain signaling fidelity.
@en
14-3-3 antagonizes Ras-mediate ...... o maintain signaling fidelity.
@nl
prefLabel
14-3-3 antagonizes Ras-mediate ...... o maintain signaling fidelity.
@en
14-3-3 antagonizes Ras-mediate ...... o maintain signaling fidelity.
@nl
P2860
P1476
14-3-3 antagonizes Ras-mediate ...... o maintain signaling fidelity.
@en
P2093
Hugh Paterson
Yvonne Light
P2860
P304
P356
10.1128/MCB.22.14.4984-4996.2002
P407
P577
2002-07-01T00:00:00Z