HIV-1 Vpu and HIV-2 Env counteract BST-2/tetherin by sequestration in a perinuclear compartment
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Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1The restriction factors of human immunodeficiency virusDifferential effects of human immunodeficiency virus type 1 Vpu on the stability of BST-2/tetherinBST-2/tetherin: a new component of the innate immune response to enveloped virusesAntiviral inhibition of enveloped virus release by tetherin/BST-2: action and counteractionThe role of BST-2/Tetherin in host protection and disease manifestationHost restriction factors for hepatitis C virusStructural and Biophysical Analysis of BST-2/Tetherin Ectodomains Reveals an Evolutionary Conserved Design to Inhibit Virus ReleaseBone marrow stromal cell antigen 2 (BST-2) restricts mouse mammary tumor virus (MMTV) replication in vivoExpression of HIV-1 Vpu leads to loss of the viral restriction factor CD317/Tetherin from lipid rafts and its enhanced lysosomal degradationMechanism of HIV-1 virion entrapment by tetherinCounteraction of the multifunctional restriction factor tetherinVpu and BST2: Still Not There Yet?Positioning of cysteine residues within the N-terminal portion of the BST-2/tetherin ectodomain is important for functional dimerization of BST-2.Modulation of HIV-1-host interaction: role of the Vpu accessory proteinAnalysis of the human immunodeficiency virus type 1 M group Vpu domains involved in antagonizing tetherin.Lack of adaptation to human tetherin in HIV-1 group O and P.Animal models for HIV/AIDS researchTetherin restricts direct cell-to-cell infection of HIV-1.The ESCRT-0 component HRS is required for HIV-1 Vpu-mediated BST-2/tetherin down-regulation.BST-2/tetherin-mediated restriction of chikungunya (CHIKV) VLP budding is counteracted by CHIKV non-structural protein 1 (nsP1)HIV-1 Vpu antagonism of tetherin inhibits antibody-dependent cellular cytotoxic responses by natural killer cells.Serine-threonine ubiquitination mediates downregulation of BST-2/tetherin and relief of restricted virion release by HIV-1 Vpu.Association of BST-2 gene variants with HIV disease progression underscores the role of BST-2 in HIV type 1 infection.Epitope tags beside the N-terminal cytoplasmic tail of human BST-2 alter its intracellular trafficking and HIV-1 restrictionDeterminants of tetherin antagonism in the transmembrane domain of the human immunodeficiency virus type 1 Vpu proteinIdentification of alternatively translated Tetherin isoforms with differing antiviral and signaling activitiesIdentification of amino acids in the human tetherin transmembrane domain responsible for HIV-1 Vpu interaction and susceptibility.Compensatory changes in the cytoplasmic tail of gp41 confer resistance to tetherin/BST-2 in a pathogenic nef-deleted SIVVpu downmodulates two distinct targets, tetherin and gibbon ape leukemia virus envelope, through shared features in the Vpu cytoplasmic tail.The HERV-K human endogenous retrovirus envelope protein antagonizes Tetherin antiviral activityThe VP40 protein of Marburg virus exhibits impaired budding and increased sensitivity to human tetherin following mouse adaptationVpu binds directly to tetherin and displaces it from nascent virions.Tetherin/BST-2 antagonism by Nef depends on a direct physical interaction between Nef and tetherin, and on clathrin-mediated endocytosis.BST-2 is rapidly down-regulated from the cell surface by the HIV-1 protein Vpu: evidence for a post-ER mechanism of Vpu-actionEx vivo gene therapy for HIV-1 treatment.Misdirection of membrane trafficking by HIV-1 Vpu and Nef: Keys to viral virulence and persistence.In COS cells Vpu can both stabilize tetherin expression and counteract its antiviral activity.Role of the endocytic pathway in the counteraction of BST-2 by human lentiviral pathogensSome human immunodeficiency virus type 1 Vpu proteins are able to antagonize macaque BST-2 in vitro and in vivo: Vpu-negative simian-human immunodeficiency viruses are attenuated in vivo.
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P2860
HIV-1 Vpu and HIV-2 Env counteract BST-2/tetherin by sequestration in a perinuclear compartment
description
2010 nî lūn-bûn
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2010年の論文
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年學術文章
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2010年學術文章
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2010年學術文章
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name
HIV-1 Vpu and HIV-2 Env counte ...... n in a perinuclear compartment
@en
HIV-1 Vpu and HIV-2 Env counte ...... in a perinuclear compartment.
@nl
type
label
HIV-1 Vpu and HIV-2 Env counte ...... n in a perinuclear compartment
@en
HIV-1 Vpu and HIV-2 Env counte ...... in a perinuclear compartment.
@nl
prefLabel
HIV-1 Vpu and HIV-2 Env counte ...... n in a perinuclear compartment
@en
HIV-1 Vpu and HIV-2 Env counte ...... in a perinuclear compartment.
@nl
P2093
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HIV-1 Vpu and HIV-2 Env counte ...... n in a perinuclear compartment
@en
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Colin M Exline
Heiko Hauser
Jill E Oldenburg
John C Guatelli
Lisa A Lopez
Paula M Cannon
Su Jung Yang
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P2888
P356
10.1186/1742-4690-7-51
P577
2010-06-07T00:00:00Z
P5875
P6179
1044748442