2,2',4'-trihydroxychalcone from Glycyrrhiza glabra as a new specific BACE1 inhibitor efficiently ameliorates memory impairment in mice.

2,2',4'-trihydroxychalcone from Glycyrrhiza glabra as a new specific BACE1 inhibitor efficiently ameliorates memory impairment in mice.

Item
http://www.wikidata.org/entity/Q39711842
L655,240, acting as a competitive BACE1 inhibitor, efficiently decreases β-amyloid peptide production in HEK293-APPswe cells.A peptide binding to the β-site of APP improves spatial memory and attenuates Aβ burden in Alzheimer's disease transgenic miceSmall molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid β production and clearance.Bacopaside I ameliorates cognitive impairment in APP/PS1 mice via immune-mediated clearance of β-amyloidThamnolia vermicularis extract improves learning ability in APP/PS1 transgenic mice by ameliorating both Aβ and Tau pathologies.Consequences of inhibiting amyloid precursor protein processing enzymes on synaptic function and plasticity.Plants traditionally used in age-related brain disorders (dementia): an ethanopharmacological survey.Interpreting Alzheimer's disease clinical trials in light of the effects on amyloid-β.Oligodendrocytes and Alzheimer's disease.Pharmacological Effects of Glycyrrhiza spp. and Its Bioactive Constituents: Update and Review.Protective and antioxidant effects of a chalconoid from Pulicaria incisa on brain astrocytes.Amyloid beta: structure, biology and structure-based therapeutic development.Cyclic cis-Locked Phospho-Dipeptides Reduce Entry of AβPP into Amyloidogenic Processing Pathway.Natural Modulators of Amyloid-Beta Precursor Protein Processing.LX2343 alleviates cognitive impairments in AD model rats by inhibiting oxidative stress-induced neuronal apoptosis and tauopathy.Screening of β-secretase and acetylcholinesterase inhibitors from plant resources.
P2860

2,2',4'-trihydroxychalcone from Glycyrrhiza glabra as a new specific BACE1 inhibitor efficiently ameliorates memory impairment in mice.

Item
http://www.wikidata.org/entity/Q39711842
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
2,2',4'-trihydroxychalcone fro ...... tes memory impairment in mice.
@en
2,2',4'-trihydroxychalcone fro ...... tes memory impairment in mice.
@nl
type
label
2,2',4'-trihydroxychalcone fro ...... tes memory impairment in mice.
@en
2,2',4'-trihydroxychalcone fro ...... tes memory impairment in mice.
@nl
prefLabel
2,2',4'-trihydroxychalcone fro ...... tes memory impairment in mice.
@en
2,2',4'-trihydroxychalcone fro ...... tes memory impairment in mice.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P356
P1433
P1476
2,2',4'-trihydroxychalcone fro ...... tes memory impairment in mice.
@en
P2093
P2860
P304
P31
P356
10.1111/J.1471-4159.2010.06751.X
P407
P433
P478
P50
P577
P5875
P698