Macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors with activity in vivo

Macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors with activity in vivo

Item
http://www.wikidata.org/entity/Q27653662
Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulationsMacrocyclic protease inhibitors with reduced peptide characterBACE1 (β-secretase) inhibitors for the treatment of Alzheimer's diseaseExploring the binding of BACE-1 inhibitors using comparative binding energy analysis (COMBINE).Beta-secretase as a target for Alzheimer's disease drug discovery: an overview of in vitro methods for characterization of inhibitors.The recent updates of therapeutic approaches against aβ for the treatment of Alzheimer's disease.Small-molecule BACE1 inhibitors: a patent literature review (2006 - 2011).The structural evolution of β-secretase inhibitors: a focus on the development of small-molecule inhibitors.BACE-1 inhibition prevents the γ-secretase inhibitor evoked Aβ rise in human neuroblastoma SH-SY5Y cells2,2',4'-trihydroxychalcone from Glycyrrhiza glabra as a new specific BACE1 inhibitor efficiently ameliorates memory impairment in mice.The Swedish APP mutation alters the effect of genetically reduced BACE1 expression on the APP processing.Synthesis and extended activity of triazole-containing macrocyclic protease inhibitors.Base catalysed synthesis of thiochromans and azo-linked chromenes using allenylphosphonates.Chemometric design to explore pharmacophore features of BACE inhibitors for controlling Alzheimer's disease.
P2860

Macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors with activity in vivo

Item
http://www.wikidata.org/entity/Q27653662
description
2009 nî lūn-bûn
@nan
2009 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մարտին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors with activity in vivo
@ast
Macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors with activity in vivo
@en
Macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors with activity in vivo
@nl
type
label
Macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors with activity in vivo
@ast
Macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors with activity in vivo
@en
Macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors with activity in vivo
@nl
prefLabel
Macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors with activity in vivo
@ast
Macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors with activity in vivo
@en
Macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors with activity in vivo
@nl
P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P356
P1433
P1476
Macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors with activity in vivo
@en
P2093
P304
P31
P356
10.1016/J.BMCL.2009.01.055
P407
P433
P478
P50
P577
P5875
P698